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Chemical Compound Review

Coriban     N-[4-[2-[2-(4- acetamidophenoxy) ethoxy]etho...

Synonyms: Coryphamin, Acemidophen, Acemidophene, Diamfenetida, Diamfenetide, ...
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Disease relevance of Diamfenetide

  • The systematic use of diamphenethide at this dose level at intervals of up to six weeks during the period of metacercarial challenge should prevent ovine fascioliasis [1].
  • When given at a dosage of 10 mg/kg of body weight, diamfenetide was 87% effective in preventing establishment of F hepatica infections in sheep that were given the drug daily for 14 days, and was 96% effective in sheep that were given the drug for 21 days [2].

High impact information on Diamfenetide


Analytical, diagnostic and therapeutic context of Diamfenetide


  1. The ability of diamphenethide to control immature Fasciola hepatica in sheep at a lower than standard dose level. Rowlands, D.T., Clampitt, R.B., Macpherson, I.S. Vet. Rec. (1985) [Pubmed]
  2. Chemoprophylaxis with diamfenetide against experimental infections of Fasciola hepatica in ruminants. Enzie, F.D., Rew, R.S., Colglazier, M.L. Am. J. Vet. Res. (1980) [Pubmed]
  3. Fasciola hepatica in vitro: increased susceptibility to fasciolicides in a defined serum-free medium. Jenkins, D.C., Topley, P., Rapson, E.B. Parasitology (1987) [Pubmed]
  4. Studies of the effect of diamphenethide and oxyclozanide on the metabolism of Fasciola hepatica. Edwards, S.R., Campbell, A.J., Sheers, M., Moore, R.J., Montague, P.E. Mol. Biochem. Parasitol. (1981) [Pubmed]
  5. Fasciola hepatica: effects of diamfenetide free amine on in vitro physiology, biochemistry, and morphology. Rew, R.S., Fetterer, R.H., Martin, T.C. Exp. Parasitol. (1983) [Pubmed]
  6. Effect of diamfenetide on experimental infections of Fasciola hepatica in lambs: anthelmintic and clinical investigations. Rew, R.S., Colglazier, n.u.l.l., Enzie, F.D. J. Parasitol. (1978) [Pubmed]
  7. An in vitro screen for new fasciolicidal agents. Ibarra, O.F., Jenkins, D.C. Zeitschrift für Parasitenkunde (Berlin, Germany) (1984) [Pubmed]
  8. Fasciola hepatica: ultrastructural changes to the tegument of juvenile flukes following incubation in vitro with the deacetylated (amine) metabolite of diamphenethide. Anderson, H.R., Fairweather, I. Int. J. Parasitol. (1995) [Pubmed]
  9. The effect of diamphenethide on protein synthesis by the liver fluke, Fasciola hepatica. Anderson, H.R., Fairweather, I., Bamford, D.R., Montgomery, W.I. Int. J. Parasitol. (1993) [Pubmed]
  10. Fasciola hepatica: tegumental surface alterations following treatment in vitro with the deacetylated (amine) metabolite of diamphenethide. Fairweather, I., Anderson, H.R., Baldwin, T.M. Parasitol. Res. (1987) [Pubmed]
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