Disease relevance of Oxiclozanidum

• A safe method of treatment for infected horses is given which involves oral medication with oxyclozanide at a dose rate of 15 ml/50 kg body weight [1].
• Decrease in hepatic microsomal UDP-glucuronosyl-transferase activity in rats and cattle with fascioliasis: impaired in vitro glucuronidation of oxyclozanide [2].
• Six fasciolicides, bithionol, bromofenofos, DS-6, nitroxynil, oxyclozanide and tribromsalan, were tested for mutagenicity in the Salmonella reverse mutation test using S. typhimurium tester strains TA100, TA98, TA1535, TA1537 and TA1538 and the micronucleus test in mice [3].

High impact information on Oxiclozanidum

• Four multivariate calibration-prediction techniques, classical least-squares, inverse least-squares, principal component regression and partial least-squares regression were applied to the spectrophotometric multicomponent analysis of a veterinary formulation containing oxfendazole (OXF) and oxyclozanide (OXC) without any separation step [4].
• Lactating cows (n = 16) from a herd naturally infected with F. hepatica were successively treated with nitroxynil (Dovenix, Specia) and with oxyclozanide (Zanil, ICI) 1 month later [5].
• Against F hepatica aged six weeks, albendazole and oxyclozanide showed no activity and clorsulon, nitroxynil and rafoxanide had only slight to moderate activity [6].
• In eight controlled tests 274 cattle were used to assess the efficacies of triclabendazole, albendazole, clorsulon, nitroxynil, oxyclozanide and rafoxanide against Fasciola hepatica [6].
• In vitro there was a similar loss of glucuronic acid conjugation of oxyclozanide by hepatic microsomes from infected cattle [2].

Associations of Oxiclozanidum with other chemical compounds

• The crude root-peel extract of Flemingia vestita, its active principle genistein and the reference flukicide oxyclozanide were tested against Fasciolopsis buski, the giant intestinal trematode [7].
• Assay of malate dehydrogenase following drug treatment in vitro failed to show any appreciable reduction in enzyme activity in Fasciola gigantica and P. explanatum but oxyclozanide and hexachlorophene produced inhibition in Fasciolopsis buski [8].

Analytical, diagnostic and therapeutic context of Oxiclozanidum

• The 17 kDa antigen was detected in the sera of infected sheep as early as 1 week after infection and, following chemotherapy with oxyclozanide, negative seroconversion occurred 2 weeks later [9].

References