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Chemical Compound Review

NTZdes     2-hydroxy-N-(5-nitro-1,3- thiazol-2...

Synonyms: Tizoxanide, CHEMBL1545, PubChem20794, ANW-60134, NSC-697856, ...
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Disease relevance of NTZdes


High impact information on NTZdes


Biological context of NTZdes

  • The only measurable species in plasma was DN, which reached a Cmax of 1.9 mg/l (range 1.1-2.5) 2-6 h after dosing, and an AUC of 3.9-11.3 mg x h/l. Its terminal half-life ranged from 1.03 to 1.6 h [8].

Anatomical context of NTZdes

  • No species other than T was detected in feces, indicating intensive intestinal deconjugation, while radioactivity and absorbance detectors showed largely unresolved clusters [9].
  • N was found to deacetylate extremely rapidly to T in plasma (half-life of about 6 minutes at 37 degrees C) as well as in presence of liver microsomes [9].
  • T was the only species obtained by incubation with human microsomes while rat microsomes yielded hydroxylated T in addition [9].

Associations of NTZdes with other chemical compounds


Analytical, diagnostic and therapeutic context of NTZdes

  • The objective of the study was to determine if metabolites other than T are present in the plasma and excreted after single dose oral administration of radiocarbon-labelled N in healthy subjects [9].
  • Selected samples were assayed by HPLC for T and submitted to metabolite identification by mass spectrometry [9].


  1. Nitazoxanide, a potential drug for eradication of Helicobacter pylori with no cross-resistance to metronidazole. Mégraud, F., Occhialini, A., Rossignol, J.F. Antimicrob. Agents Chemother. (1998) [Pubmed]
  2. Activities of tizoxanide and nitazoxanide compared to those of five other thiazolides and three other agents against anaerobic species. Pankuch, G.A., Appelbaum, P.C. Antimicrob. Agents Chemother. (2006) [Pubmed]
  3. Nitazoxanide, a nitrothiazolide antiparasitic drug, is an anti-Helicobacter pylori agent with anti-vacuolating toxin activity. Yamamoto, Y., Hakki, A., Friedman, H., Okubo, S., Shimamura, T., Hoffman, P.S., Rossignol, J. Chemotherapy. (1999) [Pubmed]
  4. In vitro effects of thiazolides on Giardia lamblia WB clone C6 cultured axenically and in coculture with Caco2 cells. Müller, J., Rühle, G., Müller, N., Rossignol, J.F., Hemphill, A. Antimicrob. Agents Chemother. (2006) [Pubmed]
  5. In vitro activity of nitazoxanide and related compounds against isolates of Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis. Adagu, I.S., Nolder, D., Warhurst, D.C., Rossignol, J.F. J. Antimicrob. Chemother. (2002) [Pubmed]
  6. Efficacy of nitazoxanide, tizoxanide and tizoxanide glucuronide against Cryptosporidium parvum development in sporozoite-infected HCT-8 enterocytic cells. Gargala, G., Delaunay, A., Li, X., Brasseur, P., Favennec, L., Ballet, J.J. J. Antimicrob. Chemother. (2000) [Pubmed]
  7. Nitazoxanide pharmacokinetics and tolerability in man during 7 days dosing with 0.5 g and 1 g b.i.d. Stockis, A., De Bruyn, S., Gengler, C., Rosillon, D. International journal of clinical pharmacology and therapeutics. (2002) [Pubmed]
  8. Pharmacokinetics of nitazoxanide after single oral dose administration in 6 healthy volunteers. Stockis, A., Deroubaix, X., Lins, R., Jeanbaptiste, B., Calderon, P., Rossignol, J.F. International journal of clinical pharmacology and therapeutics. (1996) [Pubmed]
  9. Nitazoxanide: pharmacokinetics and metabolism in man. Broekhuysen, J., Stockis, A., Lins, R.L., De Graeve, J., Rossignol, J.F. International journal of clinical pharmacology and therapeutics. (2000) [Pubmed]
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