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Chemical Compound Review

CHEMBL359887     [4-(1-acetyloxyprop-2- enyl)phenyl] ethanoate

Synonyms: AG-J-38578, SureCN3673490, NSC-711510, CTK5J3193, NSC711510, ...
 
 
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Disease relevance of NSC711510

 

High impact information on NSC711510

 

Biological context of NSC711510

 

Anatomical context of NSC711510

 

Gene context of NSC711510

  • The anti-tumor-promoting activity of 1'-acetoxychavicol acetate (ACA) was examined in a two-stage carcinogenesis experiment in ICR mouse skin using 7,12-dimethylbenz[a]anthracene (0.19 mumol) and 12-O-tetradecanoylphorbol-13-acetate (TPA; 1.6 nmol) [9].
  • 1'-Acetoxychavicol acetate inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 monocytic cells by suppressing nuclear factor-kappaB activation [10].

References

  1. 1'-acetoxychavicol acetate is a novel nuclear factor kappaB inhibitor with significant activity against multiple myeloma in vitro and in vivo. Ito, K., Nakazato, T., Xian, M.J., Yamada, T., Hozumi, N., Murakami, A., Ohigashi, H., Ikeda, Y., Kizaki, M. Cancer Res. (2005) [Pubmed]
  2. Apoptosis induced by 1'-acetoxychavicol acetate in Ehrlich ascites tumor cells is associated with modulation of polyamine metabolism and caspase-3 activation. Moffatt, J., Hashimoto, M., Kojima, A., Kennedy, D.O., Murakami, A., Koshimizu, K., Ohigashi, H., Matsui-Yuasa, I. Carcinogenesis (2000) [Pubmed]
  3. Suppression of tumor promoter-induced oxidative stress and inflammatory responses in mouse skin by a superoxide generation inhibitor 1'-acetoxychavicol acetate. Nakamura, Y., Murakami, A., Ohto, Y., Torikai, K., Tanaka, T., Ohigashi, H. Cancer Res. (1998) [Pubmed]
  4. Induction of apoptosis in human myeloid leukemic cells by 1'-acetoxychavicol acetate through a mitochondrial- and Fas-mediated dual mechanism. Ito, K., Nakazato, T., Murakami, A., Yamato, K., Miyakawa, Y., Yamada, T., Hozumi, N., Ohigashi, H., Ikeda, Y., Kizaki, M. Clin. Cancer Res. (2004) [Pubmed]
  5. Inhibition by 1'-acetoxychavicol acetate of lipopolysaccharide- and interferon-gamma-induced nitric oxide production through suppression of inducible nitric oxide synthase gene expression in RAW264 cells. Ohata, T., Fukuda, K., Murakami, A., Ohigashi, H., Sugimura, T., Wakabayashi, K. Carcinogenesis (1998) [Pubmed]
  6. A xanthine oxidase inhibitor 1'-acetoxychavicol acetate inhibits azoxymethane-induced colonic aberrant crypt foci in rats. Tanaka, T., Makita, H., Kawamori, T., Kawabata, K., Mori, H., Murakami, A., Satoh, K., Hara, A., Ohigashi, H., Koshimizu, K. Carcinogenesis (1997) [Pubmed]
  7. 1'-Acetoxychavicol acetate as an inhibitor of phagocytosis of macrophages. Watanabe, N., Kataoka, T., Tajika, T., Uramoto, M., Magae, J., Nagai, K. Biosci. Biotechnol. Biochem. (1995) [Pubmed]
  8. Zingiberaceous and citrus constituents, 1'-acetoxychavicol acetate, zerumbone, auraptene, and nobiletin, suppress lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 murine macrophages through different modes of action. Murakami, A., Shigemori, T., Ohigashi, H. J. Nutr. (2005) [Pubmed]
  9. 1'-Acetoxychavicol acetate, a superoxide anion generation inhibitor, potently inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in ICR mouse skin. Murakami, A., Ohura, S., Nakamura, Y., Koshimizu, K., Ohigashi, H. Oncology (1996) [Pubmed]
  10. 1'-Acetoxychavicol acetate inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 monocytic cells by suppressing nuclear factor-kappaB activation. Ichikawa, H., Murakami, A., Aggarwal, B.B. Mol. Cancer Res. (2006) [Pubmed]
 
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