Gene Review:
TNFSF11 - tumor necrosis factor (ligand) superfamily...
Homo sapiens
Synonyms:
CD254, ODF, OPGL, OPTB2, Osteoclast differentiation factor, ...
Ritchlin,
Hicks,
Li,
Haas-Smith,
Schwarz,
Giuliani,
Barillè,
Hojden,
La Monica,
Sammarelli,
Bonomini,
Lazzaretti,
Bataille,
Colla,
Moroni,
Rizzoli,
Sala,
Kaden,
Kiliç,
Vahl,
Haase,
Lang,
Borggrefe,
Dempfle,
Sarikoç,
Brueckmann,
Hagl,
Grobholz,
Bickelhaupt,
Zahn,
Aubin,
Bonnelye,
Allen P. Anandarajah,
Suda,
Takahashi,
Jimi,
Martin,
Udagawa,
Gillespie,
Mbalaviele,
Portanova,
Jones,
Thiede,
Monahan,
De Ciechi,
Settle,
Mnich,
Anderson,
Abu-Amer,
Stilgren,
Abrahamsen,
Rettmer,
Beck-Nielsen,
Eriksen,
Hegedüs,
Fábrega,
Orive,
Pons-Romero,
García-Suarez,
Antonio Amado,
García-Unzueta,
- Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Lacey, D.L., Timms, E., Tan, H.L., Kelley, M.J., Dunstan, C.R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., Hsu, H., Sullivan, J., Hawkins, N., Davy, E., Capparelli, C., Eli, A., Qian, Y.X., Kaufman, S., Sarosi, I., Shalhoub, V., Senaldi, G., Guo, J., Delaney, J., Boyle, W.J. Cell (1998)
- Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis. Ritchlin, C.T., Haas-Smith, S.A., Li, P., Hicks, D.G., Schwarz, E.M. J. Clin. Invest. (2003)
- Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: a potential role in multiple myeloma bone disease. Giuliani, N., Colla, S., Sala, R., Moroni, M., Lazzaretti, M., La Monica, S., Bonomini, S., Hojden, M., Sammarelli, G., Barillè, S., Bataille, R., Rizzoli, V. Blood (2002)
- Cooperation of TNF family members CD40 ligand, receptor activator of NF-kappa B ligand, and TNF-alpha in the activation of dendritic cells and the expansion of viral specific CD8+ T cell memory responses in HIV-1-infected and HIV-1-uninfected individuals. Yu, Q., Gu, J.X., Kovacs, C., Freedman, J., Thomas, E.K., Ostrowski, M.A. J. Immunol. (2003)
- Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL. Sobacchi, C., Frattini, A., Guerrini, M.M., Abinun, M., Pangrazio, A., Susani, L., Bredius, R., Mancini, G., Cant, A., Bishop, N., Grabowski, P., Del Fattore, A., Messina, C., Errigo, G., Coxon, F.P., Scott, D.I., Teti, A., Rogers, M.J., Vezzoni, P., Villa, A., Helfrich, M.H. Nat. Genet. (2007)
- Role of RANKL in bone diseases. Anandarajah, A.P. Trends Endocrinol. Metab. (2009)
- Molecular Pathways: Osteoclast-Dependent and Osteoclast-Independent Roles of the RANKL/RANK/OPG Pathway in Tumorigenesis and Metastasis. Dougall, W.C. Clin. Cancer Res. (2012)
- The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Wada, T., Nakashima, T., Oliveira-dos-Santos, A.J., Gasser, J., Hara, H., Schett, G., Penninger, J.M. Nat. Med. (2005)
- A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Anderson, D.M., Maraskovsky, E., Billingsley, W.L., Dougall, W.C., Tometsko, M.E., Roux, E.R., Teepe, M.C., DuBose, R.F., Cosman, D., Galibert, L. Nature (1997)
- Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Suda, T., Takahashi, N., Udagawa, N., Jimi, E., Gillespie, M.T., Martin, T.J. Endocr. Rev. (1999)
- Osteoprotegerin and RANKL in alcoholic liver cirrhosis. Fábrega, E., Orive, A., García-Suarez, C., García-Unzueta, M., Antonio Amado, J., Pons-Romero, F. Liver Int. (2005)
- HIV envelope gp120-mediated regulation of osteoclastogenesis via receptor activator of nuclear factor kappa B ligand (RANKL) secretion and its modulation by certain HIV protease inhibitors through interferon-gamma/RANKL cross-talk. Fakruddin, J.M., Laurence, J. J. Biol. Chem. (2003)
- The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling. Theoleyre, S., Wittrant, Y., Tat, S.K., Fortun, Y., Redini, F., Heymann, D. Cytokine Growth Factor Rev. (2004)
- The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling. Wang, M.W., Wei, S., Faccio, R., Takeshita, S., Tebas, P., Powderly, W.G., Teitelbaum, S.L., Ross, F.P. J. Clin. Invest. (2004)
- Intraarticular corticosteroids decrease synovial RANKL expression in inflammatory arthritis. Makrygiannakis, D., af Klint, E., Catrina, S.B., Botusan, I.R., Klareskog, E., Klareskog, L., Ulfgren, A.K., Catrina, A.I. Arthritis Rheum. (2006)
- Functional role for heat shock factors in the transcriptional regulation of human RANK ligand gene expression in stromal/osteoblast cells. Roccisana, J.L., Kawanabe, N., Kajiya, H., Koide, M., Roodman, G.D., Reddy, S.V. J. Biol. Chem. (2004)
- Beta1 integrin/focal adhesion kinase-mediated signaling induces intercellular adhesion molecule 1 and receptor activator of nuclear factor kappaB ligand on osteoblasts and osteoclast maturation. Nakayamada, S., Okada, Y., Saito, K., Tamura, M., Tanaka, Y. J. Biol. Chem. (2003)
- MCP-1 is induced by receptor activator of nuclear factor-{kappa}B ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formation. Kim, M.S., Day, C.J., Morrison, N.A. J. Biol. Chem. (2005)
- Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment. Giuliani, N., Bataille, R., Mancini, C., Lazzaretti, M., Barillé, S. Blood (2001)
- Identification and Characterization of the Precursors Committed to Osteoclasts Induced by TNF-Related Activation-Induced Cytokine/Receptor Activator of NF-{kappa}B Ligand. Mochizuki, A., Takami, M., Kawawa, T., Suzumoto, R., Sasaki, T., Shiba, A., Tsukasaki, H., Zhao, B., Yasuhara, R., Suzawa, T., Miyamoto, Y., Choi, Y., Kamijo, R. J. Immunol. (2006)
- Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption. Michael, H., Härkönen, P.L., Väänänen, H.K., Hentunen, T.A. J. Bone Miner. Res. (2005)
- Lipopolysaccharide supports survival and fusion of preosteoclasts independent of TNF-alpha, IL-1, and RANKL. Suda, K., Woo, J.T., Takami, M., Sexton, P.M., Nagai, K. J. Cell. Physiol. (2002)
- Osteoprotegerin and its ligand: a new paradigm for regulation of osteoclastogenesis and bone resorption. Aubin, J.E., Bonnelye, E. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (2000)
- The abundant synovial expression of the RANK/RANKL/Osteoprotegerin system in peripheral spondylarthritis is partially disconnected from inflammation. Vandooren, B., Cantaert, T., Noordenbos, T., Tak, P.P., Baeten, D. Arthritis Rheum. (2008)
- Expression of osteoprotegerin (OPG), TNF related apoptosis inducing ligand (TRAIL), and receptor activator of nuclear factor kappaB ligand (RANKL) in human breast tumours. Van Poznak, C., Cross, S.S., Saggese, M., Hudis, C., Panageas, K.S., Norton, L., Coleman, R.E., Holen, I. J. Clin. Pathol. (2006)
- Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulate aortic valve calcification. Kaden, J.J., Bickelhaupt, S., Grobholz, R., Haase, K.K., Sarikoç, A., Kiliç, R., Brueckmann, M., Lang, S., Zahn, I., Vahl, C., Hagl, S., Dempfle, C.E., Borggrefe, M. J. Mol. Cell. Cardiol. (2004)
- Intercellular adhesion molecule 1 discriminates functionally different populations of human osteoblasts: characteristic involvement of cell cycle regulators. Tanaka, Y., Maruo, A., Fujii, K., Nomi, M., Nakamura, T., Eto, S., Minami, Y. J. Bone Miner. Res. (2000)
- Induction of RANKL expression and osteoclast maturation by the binding of fibroblast growth factor 2 to heparan sulfate proteoglycan on rheumatoid synovial fibroblasts. Nakano, K., Okada, Y., Saito, K., Tanaka, Y. Arthritis Rheum. (2004)
- Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling. Mansky, K.C., Sankar, U., Han, J., Ostrowski, M.C. J. Biol. Chem. (2002)
- RANK Expression as a cell surface marker of human osteoclast precursors in peripheral blood, bone marrow, and giant cell tumors of bone. Atkins, G.J., Kostakis, P., Vincent, C., Farrugia, A.N., Houchins, J.P., Findlay, D.M., Evdokiou, A., Zannettino, A.C. J. Bone Miner. Res. (2006)
- Adiponectin Stimulates RANKL and Inhibits OPG Expression in Human Osteoblasts Through the MAPK Signaling Pathway. Luo, X.H., Guo, L.J., Xie, H., Yuan, L.Q., Wu, X.P., Zhou, H.D., Liao, E.Y. J. Bone Miner. Res. (2006)
- Human osteosarcoma cells express functional receptor activator of nuclear factor-kappa B. Mori, K., Le Goff, B., Berreur, M., Riet, A., Moreau, A., Blanchard, F., Chevalier, C., Guisle-Marsollier, I., Léger, J., Guicheux, J., Masson, M., Gouin, F., Rédini, F., Heymann, D. J. Pathol. (2007)
- Inhibition of p38 mitogen-activated protein kinase prevents inflammatory bone destruction. Mbalaviele, G., Anderson, G., Jones, A., De Ciechi, P., Settle, S., Mnich, S., Thiede, M., Abu-Amer, Y., Portanova, J., Monahan, J. J. Pharmacol. Exp. Ther. (2006)
- CD40 ligation of rheumatoid synovial fibroblasts regulates RANKL-mediated osteoclastogenesis: evidence of NF-kappaB-dependent, CD40-mediated bone destruction in rheumatoid arthritis. Lee, H.Y., Jeon, H.S., Song, E.K., Han, M.K., Park, S.I., Lee, S.I., Yun, H.J., Kim, J.R., Kim, J.S., Lee, Y.C., Kim, S.I., Kim, H.R., Choi, J.Y., Kang, I., Kim, H.Y., Yoo, W.H. Arthritis Rheum. (2006)
- Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis. Takayanagi, H., Iizuka, H., Juji, T., Nakagawa, T., Yamamoto, A., Miyazaki, T., Koshihara, Y., Oda, H., Nakamura, K., Tanaka, S. Arthritis Rheum. (2000)
- Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution. Ito, S., Wakabayashi, K., Ubukata, O., Hayashi, S., Okada, F., Hata, T. J. Biol. Chem. (2002)
- Skeletal changes in osteoprotegerin and receptor activator of nuclear factor-kappab ligand mRNA levels in primary hyperparathyroidism: effect of parathyroidectomy and association with bone metabolism. Stilgren, L.S., Rettmer, E., Eriksen, E.F., Hegedüs, L., Beck-Nielsen, H., Abrahamsen, B. Bone (2004)