Disease relevance of NSC6196

• Experiments have been designed to systematically examine the effects of carminic acid (CAR) on the antiviral/interferon-inducing activity of poly r(A-U), using the human foreskin fibroblast-vesicular stomatitis virus bioassay system [1].
• Carminic acid (CAR) enhances the antiviral activity of poly r(A-U) twelve-fold without increasing interferon induction, inactivating the vesicular stomatitis virus or inducing host cell cytotoxicity [2].

High impact information on NSC6196

• The procedure was successfully applied for identification of indigotin and carminic acid-main colorants extracted from a fiber taken from the blue-red 'Italian' tapestry (the collection of the National Museum in Warsaw, Poland) [3].
• The activities of eight human recombinant cytochrome P450 (CYP) isozymes were measured in the presence of purpurin, alizarin or carminic acid [4].
• The mutagenicity of MeIQx in TA1538 1A2/OR or 1B1/OR was suppressed by purpurin and alizarin but not by carminic acid [4].
• The measurements of relative antioxidant activities using Pyrogallol Red and other detecting molecules, such as gallocyanine and carminic acid, were in fair agreement [5].
• Carminic acid dye from the homopteran Dactylopius coccus hemolymph is consumed during treatment with different microbial elicitors [6].

Biological context of NSC6196

• Genotoxicity of fungal anthraquinones of islandicin, iridoskyrin and (-) rubroskyrin, and a colorant of insect origin, cochineal and its component, carminic acid, an anthraquinone, was examined in the hepatocyte primary culture/DNA repair test [7].

Anatomical context of NSC6196

• The excretion pattern of mutagens in urine after administration of direct brown 95 corresponds with the excretion pattern in the feces of orally administered carminic acid [8].
• Laccaic acid, one of the carminic acid samples and monascus pigments were found to be very toxic to cultured hepatocytes [9].

Associations of NSC6196 with other chemical compounds

• Genotoxicity studies in vitro and in vivo on carminic acid (natural red 4) [10].
• The interactions of such anthraquinones, i.e., carminic acid (CA) and mitoxantrone (Mx) with iron(II, III) and copper(I, II) redox couples in oxygenated and deaerated solutions, were investigated by UV-Visible and IR-spectroscopy [11].

Gene context of NSC6196

• Carminic acid was extracted with distilled water from beverage, jelly, candy, pasta sauce, yogurt, or ice cream samples [12].
• In the method developed and validated here, carminic acid is extracted by boiling the sample with HCl, purified on a solid-phase extraction cartridge, and injected on a C18 analytical column [13].

Analytical, diagnostic and therapeutic context of NSC6196

• Enzyme immunoassay for carminic acid in foods [12].
• The combination of the information from the spectrophotometric determination of carminic acid with that of the pigment profile acquired by liquid chromatography (LC) and the composition of the red and yellow pigment groups, also acquired by LC, enables greater accuracy in judging the quality of the final sample [14].
• Oral administration of carminic acid resulted in a biphasic excretion of this dye in the feces, due to coprophagy [8].
• Effects of carmine and carminic acid on embryonic tissue cell cultures [15].

References