Disease relevance of 2-(1-Piperidinyl)ethyl (2-(heptyloxy)phenyl)carbamate

• Effect of heptacaine and of some intermediary products obtained during its synthesis on Salmonella typhimurium and Escherichia coli [1].

High impact information on 2-(1-Piperidinyl)ethyl (2-(heptyloxy)phenyl)carbamate

• Determination of carbisocaine, heptacaine and pentacaine in plasma by capillary gas chromatography with nitrogen-selective detection [2].
• Electrophysiological investigations of new drugs with carbanilate structure (heptacaine, carbisocaine) on axons and sciatic nerves of the rat have shown their high local anaesthetic effect at physiological pH [3].
• Effects of local anesthetics heptacaine and carbisocaine on mouse peritoneal macrophages after 5 days of peritoneal administration were observed [4].
• Thermodynamic study of the local anaesthetic heptacaine. Study of local anaesthetics, Part: 149 [5].
• Interaction of local anesthetic heptacaine homologs with phosphatidylcholine bilayers: spin label ESR study [6].

Biological context of 2-(1-Piperidinyl)ethyl (2-(heptyloxy)phenyl)carbamate

• The heptacaine plasma concentration, 0.0083% of dose/ml, peaked at 90 min post administration and the maximum rate of its bioavailability, 0.19% of dose/min, assessed by deconvolution, occurred 38 min post administration [7].
• Pharmacokinetics of heptacaine, a novel potent local anaesthetic agent, after rectal administration to rats [7].
• The conclusions of the presented results are: 1 is stable in acidic and neutral media, the alkaline hydrolysis is faster from the start compared to the hydrolysis of heptacaine, but later obtains an equilibrium character [8].

Anatomical context of 2-(1-Piperidinyl)ethyl (2-(heptyloxy)phenyl)carbamate

• In contrast to heptacaine and trimecaine, pentacaine significantly reduces also the homing of lymph node cells to the recipients' lymph nodes and increases their homing to bone marrow [9].
• The passage of 6 model drugs; acetylsalicylic acid, chloramphenicol, ethimizol, carbisocaine, heptacaine, and diazepam, through the blood-brain barrier, was determined in unirradiated control rats and in animals 1, 3, and 7 days after irradiation of the head only with a dose of 25 Gy from a 60Co source [10].
• Pentacaine diminished the action of histamine on the tracheal smooth muscle and both pentacaine and heptacaine depressed the effects of noradrenaline and acetylcholine on anococcygeal muscle [11].

Associations of 2-(1-Piperidinyl)ethyl (2-(heptyloxy)phenyl)carbamate with other chemical compounds

• A relationship between the capacity factor k' of pentacaine, heptacaine and carbisocaine and mobile phase composition (content of methanol and water, ionic strength and pH) has been studied by HPLC [12].
• Pharmacokinetics of a local anaesthetic of the carbanilate type (Heptacaine; in the following briefly called HCP), was studied using a labelled product, N-[2-(2-[1-14C]-heptyloxyphenylcarbamoyloxy)ethyl]piperidinum++ + chloride [13].

References