Disease relevance of Carbizocaine

• The high relative local anaesthetic potency of carbisocaine and its low subcutaneous toxicity prompted wider pharmacological investigations in which the effects of carbisocaine on the central nervous system and the circulation were studied [1].
• The experiments showed that carbisocaine produced the typical effects of a local anaesthetic drug, i.e., stimulation of central nervous system, hypotension and a drop in the heart rate [1].
• Genotoxic activity was observed after application of Carbisocaine on Euglena gracilis, whereas no activity was detected by Carbisocaine, Heptacaine and Pentacaine on Salmonella typhimurium, Escherichia coli and Drosophila melanogaster [2].

High impact information on Carbizocaine

• Determination of carbisocaine, heptacaine and pentacaine in plasma by capillary gas chromatography with nitrogen-selective detection [3].
• Perturbation of lipid membranes by local anaesthetic carbisocaine [4].
• The blocking activity and pH dependence of carbanilate local anaesthetics, carbisocaine and its homologues, were tested on isolated rat sciatic nerves at pH 6.0, 7.2 and 8 [5].
• 4. Carbisocaine blocked the compound action potential more strongly than the derivatives with shorter alkoxysubstituents [5].
• No significant effects on phagocytosis were observed when carbisocaine was administrated in a daily dose 5 mg/kg [6].

Biological context of Carbizocaine

• Pharmacokinetics of carbisocaine in rats and mice [7].
• Regression analysis indicated linearity between carbisocaine plasma AUC and the IV administered dose within the range tested [7].

Anatomical context of Carbizocaine

• Comparison of the effects of carbisocaine and other local anesthetics on 32P incorporation into individual and total phospholipids in synaptosomes [8].
• Persistent suppression of phagocytosis after prolonged administration of local anesthetics carbisocaine and heptacaine in mouse leukocytes [6].

Associations of Carbizocaine with other chemical compounds

• The perturbation effects of lidocaine and Ka-O were found to increase with increasing pH of the sample, whereas the effect of carbisocaine decreased with increasing pH [9].

Gene context of Carbizocaine

• Study of local anesthetics. Part 128. HPLC study of the degradation of heptacaine and carbisocaine in urine, human and rabbit serums [10].

Analytical, diagnostic and therapeutic context of Carbizocaine

• HPLC separation of enantiomers of carbisocaine. Study of local anaesthetics, part 138 [11].

References