Disease relevance of NSC407198

• Initially, cells expressing E. coli PNP convert the non-toxic prodrug, 6-methylpurine-2'-deoxyriboside (MeP-dR) to the highly toxic membrane permeable toxin, 6-methylpurine (MeP) [1].
• We have demonstrated antitumor activity against refractory human glioma and pancreatic tumors with 6-methylpurine (MeP) using either a suicide gene therapy strategy to selectively release 6-methylpurine in tumor cells or direct intratumoral injection of 6-methylpurine itself [2].
• Cells contaminated with mycoplasma were cloned in the presence of 6-methylpurine deoxyriboside [3].

High impact information on NSC407198

• Resistance to cycloheximide and 6-methylpurine are each determined by dominant genes, ChxA2 and Mpr; the traits show phenotypic assortment [4].
• The S-9 fractions were characterized for cytosolic aldehyde oxidase (AO) activity, using three different substrates [N1-methylnicotinamide (NMN), benzaldehyde and 6-methylpurine] [5].
• Studies of purine base uptake and the in vivo and in vitro conversion to nucleotides indicated that Mepr-10 may be an adenine phosphoribosyltransferase-defective mutant, whereas Mepr-3 may be a mutant with altered feedback response to 6-methylpurine [6].
• Although germinated conidia of Neurospora crassa transport adenine through two different systems, only one of these, namely, the general purine transport system, which transports adenine, hypoxanthine, guanine, and 6-methylpurine, is present in freshly harvested conidia of the wild type [7].
• Depletion of mycoplasma from infected cell lines by limiting dilution in 6-methylpurine deoxyriboside [3].

Biological context of NSC407198

• Although the cells from the patients with complete APRT deficiency were as resistant to 6-methylpurine as the cells from the third patient, the cells from the heterozygotes for complete APRT deficiency were almost as sensitive as normal T cells [8].

Anatomical context of NSC407198

• Selective killing of Leishmania infected mouse macrophages by 6-methylpurine 2'-deoxyriboside [9].

Associations of NSC407198 with other chemical compounds

• The inhibitor of mRNA synthesis, 6-methylpurine, inhibited nitrate reductase derepression in either ammonium-grown or methylammonium-treated wild-type cells of Chlamydomonas reinhardtii, but not in nitrogen-starved cells [10].

Analytical, diagnostic and therapeutic context of NSC407198

• This effect was a direct result of increased tissue-specific conversion of 6-MPDR to the toxic metabolite 6-methylpurine (6-MP), as documented by HPLC analysis of culture supernatants [11].
• In particular at 1.75 M the effective stacking number in 6-methylpurine, as seen by neutron diffraction, was found to be approximately nine [12].
• Detection of mycoplasmas in cell cultures, using L6M, containing 6-methylpurine deoxyriboside [13].

References