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Chemical Compound Review

AC1L92VF     6-methyl-5H-purine

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Disease relevance of NSC407198


High impact information on NSC407198


Biological context of NSC407198

  • Although the cells from the patients with complete APRT deficiency were as resistant to 6-methylpurine as the cells from the third patient, the cells from the heterozygotes for complete APRT deficiency were almost as sensitive as normal T cells [8].

Anatomical context of NSC407198


Associations of NSC407198 with other chemical compounds


Analytical, diagnostic and therapeutic context of NSC407198


  1. Cell to cell contact is not required for bystander cell killing by Escherichia coli purine nucleoside phosphorylase. Hughes, B.W., King, S.A., Allan, P.W., Parker, W.B., Sorscher, E.J. J. Biol. Chem. (1998) [Pubmed]
  2. A long-acting suicide gene toxin, 6-methylpurine, inhibits slow growing tumors after a single administration. Gadi, V.K., Alexander, S.D., Waud, W.R., Allan, P.W., Parker, W.B., Sorscher, E.J. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  3. Depletion of mycoplasma from infected cell lines by limiting dilution in 6-methylpurine deoxyriboside. Ishiguro, K., Taira, S., Sasaki, T., Nariuchi, H. J. Immunol. Methods (1988) [Pubmed]
  4. Induced resistance to 6-methylpurine and cycloheximide in tetrahymena. I. Germ line mutants of T. thermophila. Byrne, B.C., Brussard, T.B., Bruns, P.J. Genetics (1978) [Pubmed]
  5. Comparison of levels of aldehyde oxidase with cytochrome P450 activities in human liver in vitro. Rodrigues, A.D. Biochem. Pharmacol. (1994) [Pubmed]
  6. Nature of 6-methylpurine inhibition and characterization of two 6-methylpurine-resistant mutants of Neurospora crassa. Pendyala, L., Smyth, J., Wellman, A.M. J. Bacteriol. (1979) [Pubmed]
  7. Developmental-stage-dependent adenine transport in Neurospora crassa. Pendyala, L., Wellman, A.M. J. Bacteriol. (1977) [Pubmed]
  8. Severe impairment in adenine metabolism with a partial deficiency of adenine phosphoribosyltransferase. Kamatani, N., Takeuchi, F., Nishida, Y., Yamanaka, H., Nishioka, K., Tatara, K., Fujimori, S., Kaneko, K., Akaoka, I., Tofuku, Y. Metab. Clin. Exp. (1985) [Pubmed]
  9. Selective killing of Leishmania infected mouse macrophages by 6-methylpurine 2'-deoxyriboside. Carson, D.A., Chang, K.P. Life Sci. (1981) [Pubmed]
  10. Regulation by ammonium of nitrate and nitrite assimilation in Chlamydomonas reinhardtii. Franco, A.R., Cárdenas, J., Fernández, E. Biochim. Biophys. Acta (1988) [Pubmed]
  11. Augmentation of melanoma-specific gene expression using a tandem melanocyte-specific enhancer results in increased cytotoxicity of the purine nucleoside phosphorylase gene in melanoma. Park, B.J., Brown, C.K., Hu, Y., Alexander, H.R., Horti, J., Raje, S., Figg, W.D., Bartlett, D.L. Hum. Gene Ther. (1999) [Pubmed]
  12. Base crystallization and base stacking in water. Martel, P. Eur. J. Biochem. (1979) [Pubmed]
  13. Detection of mycoplasmas in cell cultures, using L6M, containing 6-methylpurine deoxyriboside. Jurmanová, K., Hájková, M., Fischer, O. Archiv für experimentelle Veterinärmedizin. (1989) [Pubmed]
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