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Chemical Compound Review

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Disease relevance of TAUROCHOLIC ACID


High impact information on TAUROCHOLIC ACID

  • The perfused IBDUs absorbed TCA in a saturable, sodium-dependent manner; in addition, TCA absorption was blocked in a dose-dependent fashion by S0960, a specific inhibitor of the Na(+)/bile acid cotransporter [4].
  • Treatment of rat hepatocytes with TDCA and TCA promoted guanosine triphosphate (GTP) loading of G(i1alpha), G(i2alpha), and G(i3alpha) in vitro [5].
  • Administration of taurocholic acid (TCA) after colchicine pretreatment induced marked cholestasis [1].
  • No major differences in DAG production from PI were seen between paired samples of normal colon mucosa and primary colon tumors, in assays done in the presence of 2 mM TCA [6].
  • Our results suggest that release of endogenous PYY by TA in the colon plays a role in the inhibition of CCK-stimulated pancreatic exocrine secretion [7].

Chemical compound and disease context of TAUROCHOLIC ACID


Biological context of TAUROCHOLIC ACID

  • Our data support a hypothesis that these transporters, which comprise a new subfamily of the major facilitator superfamily, facilitate antiport of TCA and CA [8].

Anatomical context of TAUROCHOLIC ACID

  • Incubation of mitochondria with TCA induced a dose-dependent deterioration of mitochondrial function and the increase in the content of solubilized phospholipids [9].
  • In vitro study: Using intact rat liver mitochondria, the effect of taurocholic acid (TCA), one of the physiological bile salts, on the mitochondrial function and on mitochondrial phospholipids was examined [9].

Associations of TAUROCHOLIC ACID with other chemical compounds

  • RESULTS: Levels of TBA, GCA, TCA and GCDCA got gradually increased in the UDA group and the LDL + UDA group after treatment (P < 0.05), while those in the LDL group remained unchanged, showing an insignificant difference as compared with those in the control group [10].

Analytical, diagnostic and therapeutic context of TAUROCHOLIC ACID

  • Using an isolated perfusion rat-liver system, TCA infusion was also carried out on groups of non-operated control and hepatectomized rats 72 h after operation [11].


  1. Microtubule-independent choleresis and anti-cholestatic action of tauroursodeoxycholate in colchicine-treated rat liver. Nakai, T., Katagiri, K., Hoshino, M., Hayakawa, T., Ohiwa, T. Biochem. J. (1992) [Pubmed]
  2. Effect of bile acids on ischemia-reperfusion liver injury. Chazouillères, O., Ballet, F., Legendre, C., Bonnefis, M.T., Rey, C., Chrétien, Y., Poupon, R. J. Hepatol. (1991) [Pubmed]
  3. Role of bile in intestinal barrier function and its inhibitory effect on bacterial translocation in obstructive jaundice in rats. Ogata, Y., Nishi, M., Nakayama, H., Kuwahara, T., Ohnishi, Y., Tashiro, S. J. Surg. Res. (2003) [Pubmed]
  4. Perfused rat intrahepatic bile ducts secrete and absorb water, solute, and ions. Masyuk, A.I., Gong, A.Y., Kip, S., Burke, M.J., LaRusso, N.F. Gastroenterology (2000) [Pubmed]
  5. Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes. Dent, P., Fang, Y., Gupta, S., Studer, E., Mitchell, C., Spiegel, S., Hylemon, P.B. Hepatology (2005) [Pubmed]
  6. The effects of bile acids on phospholipase C activity in extracts of normal human colon mucosa and primary colon tumors. Nomoto, K., Morotomi, M., Miyake, M., Xu, D.B., LoGerfo, P.P., Weinstein, I.B. Mol. Carcinog. (1994) [Pubmed]
  7. Intracolonic infusion of bile salt stimulates release of peptide YY and inhibits cholecystokinin-stimulated pancreatic exocrine secretion in conscious dogs. Izukura, M., Hashimoto, T., Gomez, G., Uchida, T., Greeley, G.H., Thompson, J.C. Pancreas (1991) [Pubmed]
  8. CbsT2 from Lactobacillus johnsonii 100-100 is a transport protein of the major facilitator superfamily that facilitates bile acid antiport. Elkins, C.A., Savage, D.C. J. Mol. Microbiol. Biotechnol. (2003) [Pubmed]
  9. Mechanism of liver mitochondrial dysfunction associated with bile duct obstruction. Nishimura, D., Imoto, M., Satake, T., Sugiyama, S., Ozawa, T. Arzneimittel-Forschung. (1985) [Pubmed]
  10. Effects of choleretics on bile compositions drained from patients with pigment gallstone. Sun, B.J., Cui, N.Q., Li, D.H., Wang, Q. Chinese journal of integrative medicine. (2006) [Pubmed]
  11. Comparative studies on bile flow and biliary lipid excretion after bile-acid loading in normal and partially hepatectomized rats. Hoshino, M., Hirano, A., Hayakawa, T., Kamiya, Y., Ohiwa, T., Tanaka, A., Kumai, T., Katagiri, K., Miyaji, M., Takeuchi, T. Biochem. J. (1995) [Pubmed]
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