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Chemical Compound Review

Taurodeoxycholate     2-[4-[ (3R,5R,8S,9S,10S,12S,13R,14S,1 7R)-3...

Synonyms: CCRIS 712, CTK4J4625, LS-175294, AC1L1VJ7, 516-50-7, ...
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Disease relevance of TAURODEOXYCHOLIC ACID


High impact information on TAURODEOXYCHOLIC ACID


Chemical compound and disease context of TAURODEOXYCHOLIC ACID


Biological context of TAURODEOXYCHOLIC ACID


Anatomical context of TAURODEOXYCHOLIC ACID


Associations of TAURODEOXYCHOLIC ACID with other chemical compounds



  • Short term (30 min) incubations with 1-5 mM unconjugated bile acids or taurodeoxycholic acid induced mucin release relative to bile acid hydrophobicity [24].
  • These cells proliferate in response to EGF and are damaged by TDCA at concentrations below those normally associated with detergent-like activity and below levels observed in bile and duodenal secretions [13].

Analytical, diagnostic and therapeutic context of TAURODEOXYCHOLIC ACID


  1. Effect of tauroursodeoxycholic and ursodeoxycholic acid on ethanol-induced cell injuries in the human Hep G2 cell line. Neuman, M.G., Cameron, R.G., Shear, N.H., Bellentani, S., Tiribelli, C. Gastroenterology (1995) [Pubmed]
  2. Bile salt hydrolase activity and resistance to toxicity of conjugated bile salts are unrelated properties in lactobacilli. Moser, S.A., Savage, D.C. Appl. Environ. Microbiol. (2001) [Pubmed]
  3. Early phase components of the kallikrein kinin system in hemorrhagic ascitic fluid and plasma in the rat with induced acute pancreatitis. Seung, W.P., Feldman, B.F. Am. J. Vet. Res. (1985) [Pubmed]
  4. Duodenogastric reflux: correlations among bile acid pattern, mucus secretion, and mucosal damage. Masci, E., Testoni, P.A., Fanti, L., Guslandi, M., Zuin, M., Tittobello, A. Scand. J. Gastroenterol. (1987) [Pubmed]
  5. Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes. Dent, P., Fang, Y., Gupta, S., Studer, E., Mitchell, C., Spiegel, S., Hylemon, P.B. Hepatology (2005) [Pubmed]
  6. Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes. Rao, Y.P., Studer, E.J., Stravitz, R.T., Gupta, S., Qiao, L., Dent, P., Hylemon, P.B. Hepatology (2002) [Pubmed]
  7. Bile acid structure and selective modulation of murine hepatic cytochrome P450-linked enzymes. Paolini, M., Pozzetti, L., Piazza, F., Cantelli-Forti, G., Roda, A. Hepatology (1999) [Pubmed]
  8. Microsomal enzymes of cholesterol biosynthesis from lanosterol. Solubilization and purification of steroid 8-isomerase. Paik, Y.K., Billheimer, J.T., Magolda, R.L., Gaylor, J.L. J. Biol. Chem. (1986) [Pubmed]
  9. Isolation and characterization of a Lactobacillus amylovorus mutant depleted in conjugated bile salt hydrolase activity: relation between activity and bile salt resistance. Grill, J.P., Cayuela, C., Antoine, J.M., Schneider, F. J. Appl. Microbiol. (2000) [Pubmed]
  10. Taurodeoxycholic acid stimulates rabbit gallbladder eicosanoid release. Myers, S.I., Riva, A., Kalley-Taylor, B., Bartula, L. Prostaglandins Leukot. Essent. Fatty Acids (1995) [Pubmed]
  11. Effect of bile acids on lipid peroxidation: the role of iron. Sreejayan, N., von Ritter, C. Free Radic. Biol. Med. (1998) [Pubmed]
  12. Differential effects of deoxycholic acid and taurodeoxycholic acid on NF-kappa B signal transduction and IL-8 gene expression in colonic epithelial cells. Mühlbauer, M., Allard, B., Bosserhoff, A.K., Kiessling, S., Herfarth, H., Rogler, G., Schölmerich, J., Jobin, C., Hellerbrand, C. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  13. The pancreatic duct epithelium in vitro: bile acid injury and the effect of epidermal growth factor. Alvarez, C., Nelms, C., D'Addio, V., Bass, B.L. Surgery (1997) [Pubmed]
  14. Effect of vehicle on the nasal absorption of epinephrine during cardiopulmonary resuscitation. Bleske, B.E., Rice, T.L., Warren, E.W., Giacherio, D.A., Gilligan, L.J., Massey, K.D., Chrisp, C.E., Tait, A.R. Pharmacotherapy (1996) [Pubmed]
  15. Bile salt stimulates intestinal epithelial cell migration through TGFbeta after wounding. Strauch, E.D., Wang, J.Y., Bass, B.L. J. Surg. Res. (2001) [Pubmed]
  16. Differences in Ca(2+) signaling underlie age-specific effects of secretagogues on colonic Cl(-) transport. Venkatasubramanian, J., Selvaraj, N., Carlos, M., Skaluba, S., Rasenick, M.M., Rao, M.C. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
  17. Regulation of cholesterol synthesis in isolated epithelial cells of human small intestine. Sviridov, D.D., Safonova, I.G., Talalaev, A.G., Repin, V.S., Smirnov, V.N. Lipids (1986) [Pubmed]
  18. A new method for purification of Eimeria tenella merozoites. Xie, M.Q., Gilbert, J.M., Fuller, A.L., McDougald, L.R. Parasitol. Res. (1990) [Pubmed]
  19. Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes. Fang, Y., Han, S.I., Mitchell, C., Gupta, S., Studer, E., Grant, S., Hylemon, P.B., Dent, P. Hepatology (2004) [Pubmed]
  20. The effect of antacids on the occurrence of bile acid and aspirin-induced gastric lesions in rats. Morgan, R.J., Nelson, L.M., Russell, R.I., Plevin, T. Eur. J. Clin. Invest. (1980) [Pubmed]
  21. Conformational determinants in receptor recognition of peptide hormones: interaction of parathyroid hormone with the glucagon receptor. Shah, G.V., Epand, R.M., Orlowski, R.C. Mol. Cell. Endocrinol. (1987) [Pubmed]
  22. Bile salt toxicity to some bifidobacteria strains: role of conjugated bile salt hydrolase and pH. Grill, J.P., Perrin, S., Schneider, F. Can. J. Microbiol. (2000) [Pubmed]
  23. Tauroursodeoxycholic acid enhances phagocytosis of the cultured rat Kupffer cell. Funaoka, M., Komatsu, M., Toyoshima, I., Mikami, K., Ono, T., Hoshino, T., Kato, J., Kuramitsu, T., Ishii, T., Masamune, O. J. Gastroenterol. Hepatol. (1999) [Pubmed]
  24. Bile acid-induced alterations of mucin production in differentiated human colon cancer cell lines. Shekels, L.L., Lyftogt, C.T., Ho, S.B. Int. J. Biochem. Cell Biol. (1996) [Pubmed]
  25. Enantiomeric resolution of selenoamino acid derivatives by micellar electrokinetic chromatography (MEKC) with sodium dodecyl sulphate and a mixture of beta-cyclodextrin and taurodeoxycholic acid as chiral selectors. Pérez Méndez, S., Blanco González, E., Sanz-Medel, A. Biomed. Chromatogr. (2000) [Pubmed]
  26. Effects of sphincter of Oddi bypass on bile acid metabolism in fed and fasted intact and cholecystectomized dogs. Ramakrishnan, V.R., Beher, W.T., Lin, G.J., Stradnieks, S., Samhouri, F., Toledo-Pereyra, L.H., Block, M.A. Digestion (1981) [Pubmed]
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