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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1L9JW6     [(2S)-1-hydroxy-3- nonanoyloxy-propan-2-yl]...

Synonyms: 1EM
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High impact information on DIACYL GLYCEROL


Biological context of DIACYL GLYCEROL


Anatomical context of DIACYL GLYCEROL

  • This level of superoxide can be greatly increased in neutrophils pretreated for 30 min with 10 microM of the diacyl-glycerol kinase inhibitor R59022 [7].
  • In some invertebrate photoreceptors, excitation is mediated by release of Ca(2+) from intracellular stores by InsP(3); however, in Drosophila melanogaster, recent evidence suggests instead that a lipid messenger, such as DAG, its metabolites and/or the reduction in PIP(2) levels, may mediate excitation [8].
  • Therefore, the monoacylglycerol 3-P formation was less than 10% of the diacylglycerol 3-P formation in the assay containing no albumin and with the rat subcellular fractions, whereas nearly four times more monoacyl- than diacyl-glycerol 3-P was synthesized in the presence of 20 mg albumin [6].

Associations of DIACYL GLYCEROL with other chemical compounds

  • We suggest that the 17-kDa antigen is indeed GPI anchored and that the anchor contains an acylated inositol and either a lyso-acyl- or a diacyl-glycerol [9].

Gene context of DIACYL GLYCEROL


  1. InsP3 receptor is essential for growth and differentiation but not for vision in Drosophila. Acharya, J.K., Jalink, K., Hardy, R.W., Hartenstein, V., Zuker, C.S. Neuron (1997) [Pubmed]
  2. Pollen Tube Tip Growth Depends on Plasma Membrane Polarization Mediated by Tobacco PLC3 Activity and Endocytic Membrane Recycling. Helling, D., Possart, A., Cottier, S., Klahre, U., Kost, B. Plant Cell (2006) [Pubmed]
  3. Phosphatidic acid and lysophosphatidic acid induce haptotactic migration of human monocytes. Zhou, D., Luini, W., Bernasconi, S., Diomede, L., Salmona, M., Mantovani, A., Sozzani, S. J. Biol. Chem. (1995) [Pubmed]
  4. In vivo mechanisms of vascular endothelial growth factor-mediated increased hydraulic conductivity of Rana capillaries. Pocock, T.M., Bates, D.O. J. Physiol. (Lond.) (2001) [Pubmed]
  5. Synthesis of platelet activating factor by cholinephosphotransferase in developing fetal rabbit lung. Hoffman, D.R., Bateman, M.K., Johnston, J.M. Lipids (1988) [Pubmed]
  6. Phosphatidic acid synthesis in the heart. 1. Effect of age and species difference in the mitochondrial and microsomal synthesis. Kako, K.J., Zaror-Behrens, G., Peckett, S.D. Can. J. Biochem. (1977) [Pubmed]
  7. The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7. Gomez-Cambronero, J., Molski, T.F., Becker, E.L., Sha'afi, R.I. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  8. Phototransduction in Drosophila melanogaster. Hardie, R.C. J. Exp. Biol. (2001) [Pubmed]
  9. The immunodominant 17-kDa antigen from Cryptosporidium parvum is glycosylphosphatidylinositol-anchored. Priest, J.W., Xie, L.T., Arrowood, M.J., Lammie, P.J. Mol. Biochem. Parasitol. (2001) [Pubmed]
  10. Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase C gamma. Irie, K., Yanai, Y., Oie, K., Ishizawa, J., Nakagawa, Y., Ohigashi, H., Wender, P.A., Kikkawa, U. Bioorg. Med. Chem. (1997) [Pubmed]
  11. Effects of TNF-alpha on expression of ICAM-1 in human airway epithelial cells in vitro. Signaling pathways controlling surface and gene expression. Krunkosky, T.M., Fischer, B.M., Martin, L.D., Jones, N., Akley, N.J., Adler, K.B. Am. J. Respir. Cell Mol. Biol. (2000) [Pubmed]
  12. The eicosanoid lipid precursors diacyl-glycerol and phosphatidic acid are formed by phospholipase D in neutrophils. Billah, M.M., Eckel, S., Mullmann, T.J., Pai, J.K., Siegel, M.I., Egan, R.W. Adv. Prostaglandin Thromboxane Leukot. Res. (1991) [Pubmed]
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