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Chemical Compound Review:

Applaud 5-phenyl-3-propan-2-yl-2- tert-butylimino-1...

Synonyms: BUPROFEZIN, Buprofenzin, Buprofezine, SureCN26901, SureCN26902, ...

Fahmy, M.A. et al., James, D.G., Herrera, L.A. et al., Ishaaya, I. et al., Toscano, N.C. et al.

Toscano, Prabhaker, Castle, Henneberry, James,

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Disease relevance of Applaud

The percentage of chromosomal aberrations reached 23 +/- 0.73, 10.5 +/- 0.64 and 15 +/- 1.4 after treatment with the highest tested dose of profenofos, buprofezin and Super Royal, respectively [1].
However, no correlation was observed between buprofezin and pyriproxyfen toxicity in any of the strains [2].

High impact information on Applaud

Treatment with buprofezin did not cause a detectable induction of DNA repair synthesis, an indicator of DNA damage, but significantly increased the frequency of micronuclei [3].
Buprofezin and Super Royal had no significant effect on mouse spermatocytes at the tested concentrations [1].
The same trend of results was noticed only at the highest tested dose of buprofezin and Super Royal. With respect to germ cells, profenofos is also a potent inducer of chromosomal aberrations in 1ry spermatocytes, giving percentages of 14 +/- 1.3 and 19 +/- 1.6 at the two higher doses of 4.25 and 8.5 mg kg(-1) body wt., respectively [1].
Very few H. axyridis larvae (3.1%) treated with buprofezin reached adulthood, although 65% of treated pupae emerged successfully [4].
Novaluron has no cross-resistance with other leading compounds for controlling whiteflies such as buprofezin and pyriproxyfen [5].

Biological context of Applaud

In conclusion, the present investigation indicates that the two pest control agents buprofezin and Super Royal are relatively much safer compounds than the conventional organophosphorus insecticides [1].

Anatomical context of Applaud

The results suggest that morphological transformation of Syrian hamster embryo cells by buprofezin results from an interaction of the compound or a metabolite of it with the mitotic apparatus rather than from DNA damage [3].

Analytical, diagnostic and therapeutic context of Applaud

The effect of buprofezin, a chitin synthesis inhibitor, on development and survival of immature stages of Harmonia axyridis (Pallas), Stethortus punctum picipes Casey, Orius tristicolor (White), Geocoris pallens Stål, and Geocoris punctipes (Say), was examined in a series of laboratory bioassays [4].

References

Genotoxicity evaluation of buprofezin, petroleum oil and profenofos in somatic and germ cells of male mice. Fahmy, M.A., Abdalla, E.F. Journal of applied toxicology : JAT. (1998) [Pubmed]
Inter-regional differences in baseline toxicity of Bemisia argentifolii (Homoptera: Aleyrodidae) to the two insect growth regulators, buprofezin and pyriproxyfen. Toscano, N.C., Prabhaker, N., Castle, S.J., Henneberry, T.J. J. Econ. Entomol. (2001) [Pubmed]
The insecticide buprofezin induces morphological transformation and kinetochore-positive micronuclei in cultured Syrian hamster embryo cells in the absence of detectable DNA damage. Herrera, L.A., Ostrosky-Wegman, P., Schiffmann, D., Chen, Q.Y., Ziegler-Skylakakis, K., Andrae, U. Mutat. Res. (1993) [Pubmed]
Effect of buprofezin on survival of immature stages of Harmonia axyridis, Stethorus punctum picipes (Coleoptera: Coccinellidae), Orius tristicolor (Hemiptera: Anthocoridae), and Geocoris spp. (Hemiptera: Geocoridae). James, D.G. J. Econ. Entomol. (2004) [Pubmed]
Novaluron (Rimon), a novel IGR--mechanism, selectivity and importance in IPM programs. Ishaaya, I., Horowitz, A.R., Tirry, L., Barazani, A. Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen) (2002) [Pubmed]

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