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Chemical Compound Review

Pyriproxifen     2-[1-(4- phenoxyphenoxy)propan-2...

Synonyms: Pyriproxyfen, PubChem23006, SureCN26721, AGN-PC-00M8PT, AG-L-25281, ...
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Disease relevance of SK 591


Psychiatry related information on SK 591

  • Exposure of males to 20 micrograms S31183 did not impair their ability to inseminate females; transfer of material during copulation was sufficient to prevent the production of viable offspring by their mates.(ABSTRACT TRUNCATED AT 250 WORDS)[6]
  • Three laboratory experiments were conducted to determine the competitive outcomes between S. invicta pitted against L. humile: 1) agonistic behavior of workers in small arenas, 2) colony interactions with different population ratios, and 3) the effects of pyriproxyfen on the competitiveness of S. invicta against L. humile [7].
  • Only 11.2% of pyriproxyfen treated, emergent females (n = 32), and 11.5% of treated emergent males (n = 25) from 285 ticks treated as engorged nymphs, exhibited normal physical appearance and possessed a full range of locomotor activity [8].

High impact information on SK 591


Chemical compound and disease context of SK 591


Biological context of SK 591

  • The use of S-31183 for treating wastewater lagoons at doses which are effective for mosquito control did not result in any apparent problems of environmental incompatibility [15].
  • In contrast, pyriproxyfen (PYR) and tebufenozide (TEB) did not affect fecundity and egg fertility [16].
  • The above results are of special interest, indicating a possible alternation between novaluron, pyriproxyfen, and neonicotinoids in insecticide-resistance management programs aiming at preventing resistance development to these novel groups of insecticides against important pests such as whitefly and lepidopteran species [17].
  • However, continuous exposure to pyriproxyfen (0.01 ppm) during a 3-brood, 14-day life cycle test, suppressed the growth of D.carinata and reduced reproduction by as much as 80% [1].
  • Some variation of results could be due to interactions between females at the oviposition site, possibly causing disproportionate transfer of pyriproxyfen to larval microcosms [18].

Anatomical context of SK 591

  • Furthermore, it suggests that the fat body must be as important as the gut for the metabolism of pyriproxyfen in resistant housefly larvae [19].
  • Its temporary appearance in the hemolymph of last instar larvae, its subunit composition (M(r) approximately 82,000) and its suppression by pyriproxyfen suggests that this protein is a storage protein as well [20].
  • In vitro metabolism of pyriproxyfen by microsomes from susceptible and resistant housefly larvae [19].
  • In addition to these toxic effects on adults, pyriproxyfen also induced formation of large autophagic vacuoles in maturing oocytes leading to partial reabsorption of yolk, degeneration of the nucleus, and lysis of the follicular epithelium [21].

Associations of SK 591 with other chemical compounds


Gene context of SK 591

  • This study confirmed that microsomal cytochrome P450 monooxygenases play an important role in the pyriproxyfen resistance of the housefly [19].
  • In vitro metabolism studies of pyriproxyfen indicated that the metabolic rates were much higher in both the gut and fat body of YPPF larvae than of YS and SRS larvae [19].

Analytical, diagnostic and therapeutic context of SK 591

  • Light and transmission electron microscopy demonstrated that treatment with pyriproxyfen produced a visible decrease in the amount of tergal gland tissue present, a deformation of the overall shape of the gland located on tergite seven, and a less orderly arrangement of the secretory cells in the tissue [25].
  • The field bioassays indicated that a single treatment of pyriproxyfen effectively inhibited the emergence of adult mosquitoes in the riverbed pools for a period of 190 days [26].
  • The mean number of eggs retained in the pyriproxyfen group was higher (70.3) than in the control group (41.6) [27].


  1. Sensitivity of Daphnia carinata sensu lato to the insect growth regulator, pyriproxyfen. Trayler, K.M., Davis, J.A. Ecotoxicol. Environ. Saf. (1996) [Pubmed]
  2. Efficacy of a collar impregnated with amitraz and pyriproxyfen for prevention of experimental tick infestations by Rhipicephalus sanguineus, Ixodes ricinus, and Ixodes scapularis in dogs. Estrada-Peña, A., Rème, C. J. Am. Vet. Med. Assoc. (2005) [Pubmed]
  3. Acute toxicity of selected pesticides to the estuarine shrimp Leander tenuicornis (Decapoda:Palaemonidae). Brown, M.D., Thomas, D., Watson, K., Greenwood, J.G., Kay, B.H. J. Am. Mosq. Control Assoc. (1996) [Pubmed]
  4. Laboratory and field evaluation of the insect growth regulator pyriproxyfen (Sumilarv 0.5G) against dengue vectors. Vythilingam, I., Luz, B.M., Hanni, R., Beng, T.S., Huat, T.C. J. Am. Mosq. Control Assoc. (2005) [Pubmed]
  5. Prevention of sand fly attack by topical application of a permethrin/pyriproxyfen combination on dogs. Mercier, P., Jasmin, P., Sanquer, A. Vet. Ther. (2003) [Pubmed]
  6. Juvenile hormone mimics as effective sterilants for the tsetse fly Glossina morsitans morsitans. Langley, P.A., Felton, T., Oouchi, H. Med. Vet. Entomol. (1988) [Pubmed]
  7. Aggressive interactions between Solenopsis invicta and Linepithema humile (Hymenoptera: Formicidae) under laboratory conditions. Kabashima, J.N., Greenberg, L., Rust, M.K., Paine, T.D. J. Econ. Entomol. (2007) [Pubmed]
  8. Effects of pyriproxyfen on off-host water-balance and survival of adult lone star ticks (Acari: Ixodidae). Strey, O.F., Teel, P.D., Longnecker, M.T. J. Med. Entomol. (2001) [Pubmed]
  9. Organization and repression by juvenile hormone of a vitellogenin gene cluster in the crustacean, Daphnia magna. Tokishita, S., Kato, Y., Kobayashi, T., Nakamura, S., Ohta, T., Yamagata, H. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  10. Liquid chromatography-electrospray quadrupole ion-trap mass spectrometry of nine pesticides in fruits. Soler, C., Mañes, J., Picó, Y. Journal of chromatography. A. (2004) [Pubmed]
  11. Evaluation of a spray of permethrin and pyriproxyfen for the protection of dogs against Phlebotomus perniciosus. Molina, R., Miró, G., Gálvez, R., Nieto, J., Descalzo, M.A. Vet. Rec. (2006) [Pubmed]
  12. Tomato metabolism and porphyrin-catalyzed oxidation of pyriproxyfen. Fukushima, M., Fujisawa, T., Katagi, T. J. Agric. Food Chem. (2005) [Pubmed]
  13. Acute toxicity of selected pesticides to the Pacific blue-eye, Pseudomugil signifer (Pisces). Brown, M.D., Thomas, D., Kay, B.H. J. Am. Mosq. Control Assoc. (1998) [Pubmed]
  14. Inter-regional differences in baseline toxicity of Bemisia argentifolii (Homoptera: Aleyrodidae) to the two insect growth regulators, buprofezin and pyriproxyfen. Toscano, N.C., Prabhaker, N., Castle, S.J., Henneberry, T.J. J. Econ. Entomol. (2001) [Pubmed]
  15. Studies on the environmental persistence of S-31183 (pyriproxyfen): adsorption onto organic matter and potential for leaching through soil. Schaefer, C.H., Dupras, E.F., Mulligan, F.S. Ecotoxicol. Environ. Saf. (1991) [Pubmed]
  16. Significance of penetration, excretion, and transovarial uptake to toxicity of three insect growth regulators in predatory lacewing adults. Medina, P., Smagghe, G., Budia, F., Del Estal, P., Tirry, L., Viñuela, E. Arch. Insect Biochem. Physiol. (2002) [Pubmed]
  17. Novaluron (Rimon), a novel IGR: potency and cross-resistance. Ishaaya, I., Kontsedalov, S., Horowitz, A.R. Arch. Insect Biochem. Physiol. (2003) [Pubmed]
  18. Horizontal transfer of the insect growth regulator pyriproxyfen to larval microcosms by gravid Aedes albopictus and Ochlerotatus triseriatus mosquitoes in the laboratory. Dell Chism, B., Apperson, C.S. Med. Vet. Entomol. (2003) [Pubmed]
  19. In vitro metabolism of pyriproxyfen by microsomes from susceptible and resistant housefly larvae. Zhang, L., Kasai, S., Shono, T. Arch. Insect Biochem. Physiol. (1998) [Pubmed]
  20. Storage proteins are present in the hemolymph from larvae and adults of the Colorado potato beetle. Koopmanschap, B., Lammers, H., de Kort, S. Arch. Insect Biochem. Physiol. (1992) [Pubmed]
  21. Toxicity and histopathology of the growth regulator pyriproxyfen to adults and eggs of the cat flea (Siphonaptera:Pulicidae). Meola, R., Pullen, S., Meola, S. J. Med. Entomol. (1996) [Pubmed]
  22. Synthesis of haptens and protein conjugates for the development of immunoassays for the insect growth regulator fenoxycarb. Szurdoki, F., Székács, A., Le, H.M., Hammock, B.D. J. Agric. Food Chem. (2002) [Pubmed]
  23. Laboratory and field comparisons of pyriproxyfen, polystyrene beads and other larvicidal methods against malaria vectors in Sri Lanka. Yapabandara, A.M., Curtis, C.F. Acta Trop. (2002) [Pubmed]
  24. Effects of pyriproxyfen spray, powder, and oral bait treatments on the relative abundance of nontarget arthropods of black-tailed prairie dog (Rodentia: Sciuridae) towns. Karhu, R.R., Anderson, S.H. J. Med. Entomol. (2000) [Pubmed]
  25. Effects of the juvenile hormone analog pyriproxyfen on German cockroach, Blattella germanica (L.), tergal gland development and production of tergal gland secretion proteins. Saltzmann, K.A., Saltzmann, K.D., Neal, J.J., Scharf, M.E., Bennett, G.W. Arch. Insect Biochem. Physiol. (2006) [Pubmed]
  26. Control of vectors and incidence of malaria in an irrigated settlement scheme in Sri Lanka by using the insect growth regulator pyriproxyfen. Yapabandara, A.M., Curtis, C.F. J. Am. Mosq. Control Assoc. (2004) [Pubmed]
  27. Laboratory evaluation of pyriproxifen treated bednets on mosquito fertility and fecundity. A preliminary study. Aiku, A.O., Yates, A., Rowland, M. West African journal of medicine. (2006) [Pubmed]
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