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Chemical Compound Review

bilirubin     3-[2-[[3-(2-carboxyethyl)-5- [(Z)-(3...

Synonyms: Basinite, Hematoidin, Hemetoidin, PHEOPHYTIN, AC1NQWXK, ...
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High impact information on Hematoidin


Biological context of Hematoidin


Anatomical context of Hematoidin

  • Azopigment analysis was performed on conjugates of bilirubin-IXalpha in bile of man and rats obtained after obstruction of the bile duct or in bile incubated under N2 [7].

Analytical, diagnostic and therapeutic context of Hematoidin

  • Photobilirubin II is the unidentified major photoderivative described previously, whereas formation of photobilirubins IA and IB, and their reversion to bilirubin-IXalpha, account for the remarkably increased output of the parent pigment during phototherapy [8].
  • Leaks were defined as drain bili/serum bill > 3, total drain output > 10 mL/kg, and/or extravasation on cholangiography [9].
  • When rats were pretreated with an intraperitoneal injection of hemin, an HO-1 inducer, mesenteric tissues, including their microvessels, displayed a marked induction of HO-1 concurrent with an increase in plasma concentrations of bilirubin-IXalpha, the product of HO-catalyzed degradation of protoheme IX [10].


  1. Leydig cell-derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress. Ozawa, N., Goda, N., Makino, N., Yamaguchi, T., Yoshimura, Y., Suematsu, M. J. Clin. Invest. (2002) [Pubmed]
  2. Conjugated and unconjugated bilirubins in humans and rhesus monkeys. Structural identity of bilirubins from biles and meconiums of newborn humans and rhesus monkeys. Blumenthal, S.G., Taggart, D.B., Rasmussen, R.D., Ikeda, R.M., Ruebner, B.H., Bergstrom, D.E., Hanson, F.W. Biochem. J. (1979) [Pubmed]
  3. Carbon monoxide as a guardian against hepatobiliary dysfunction. Suematsu, M., Tsukada, K., Tajima, T., Yamamoto, T., Ochiai, D., Watanabe, H., Yoshimura, Y., Goda, N. Alcohol. Clin. Exp. Res. (2005) [Pubmed]
  4. Altered cholesterol synthesis as a mechanism involved in methyl isobutyl ketone-potentiated experimental cholestasis. Duguay, A., Plaa, G.L. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  5. Bilirubin-IXalpha and -IXbeta pigments, coproporphyrins and bile acids in meconium and stools from full-term and preterm neonates during the first month of life. Aziz, S., Kotal, P., Leroy, P., Servaes, R., Eggermont, E., Fevery, J. Acta Paediatr. (2001) [Pubmed]
  6. Carbon monoxide from heme catabolism protects against hepatobiliary dysfunction in endotoxin-treated rat liver. Kyokane, T., Norimizu, S., Taniai, H., Yamaguchi, T., Takeoka, S., Tsuchida, E., Naito, M., Nimura, Y., Ishimura, Y., Suematsu, M. Gastroenterology (2001) [Pubmed]
  7. Rearranged glucuronic acid conjugates of bilirubin-IX alpha in post-obstructive bile. Structure elucidation of azopigments beta and gamma as ethyl anthranilate N-glycosides derived from 2-, 3- and 4-o-acyl glucuronides. Compernolle, F., Van Hees, G.P., Heirwegh, K.P. Biomed. Mass Spectrom. (1978) [Pubmed]
  8. Excretion of administered and endogenous photobilirubins in the bile of the jaundice gunn rat. Stoll, M.S., Zenone, E.A., Ostrow, J.D. J. Clin. Invest. (1981) [Pubmed]
  9. Biliary reconstruction is enhanced with a collagen-polyethylene glycol sealant. Wise, P.E., Wudel, L.J., Belous, A.E., Allos, T.M., Kuhn, S.J., Feurer, I.D., Washington, M.K., Pinson, C.W., Chapman, W.C. The American surgeon. (2002) [Pubmed]
  10. Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: role of bilirubin generated by the enzyme. Hayashi, S., Takamiya, R., Yamaguchi, T., Matsumoto, K., Tojo, S.J., Tamatani, T., Kitajima, M., Makino, N., Ishimura, Y., Suematsu, M. Circ. Res. (1999) [Pubmed]
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