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Chemical Compound Review:

Hemabate (E)-7-[(1R,2S,3R,5S)-3,5- dihydroxy-2-[(E...

Synonyms: Prostin / 15M, SureCN340643, CHEMBL1200954, CHEMBL1909299, DAP001215, ...

De La Vega, G.A. et al., Halstead, G.W. et al., Ippoliti, C. et al., Goel, A.K. et al., Kranc, D.M. et al., et al.

Bygdeman, De La Vega, Avery, Nemiroff, Marchiano,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CARBOPROST

In the established hemorrhagic cystitis arm, the group treated with 1.6 mg.% carboprost tromethamine showed the best response (p less than 0.05), whereas the group treated with 0.9% normal saline showed the poorest response [1].
In all but 1 patient, bladder spasms developed during treatment with carboprost, but were not sufficiently severe to discontinue therapy [2].
Use of carboprost to facilitate hysteroscopic resection of submucous myomas [3].
The majority of the units use oxytocin, ergometrine and carboprost as a 'first-line' for the treatment of postpartum hemorrhage [4].
To synchronize oestrus, a luteolytic dose of carboprost tromethamine (Upjohn, UK) was administered intramuscularly to all does at the dose rate of 5 microg per kg body weight in a double dose schedule with an interval of 11 days [5].

High impact information on CARBOPROST

A conservative surgical treatment under general anesthesia involved intracervical infiltration of carboprost, cerclage, suction curettage of cervix, and Foley balloon tamponade was performed [6].
The effects of temperature, pH, and apparatus design on in vitro drug release from a controlled-release vaginal device containing the prostaglandin, carboprost methyl, were investigated and a semi-automated drug release test was developed based on these studies [7].
Second trimester abortion with ethacridine lactate plus carboprost--which is the best time to administer the carboprost [8]?

Analytical, diagnostic and therapeutic context of CARBOPROST

Intravesicular carboprost for the treatment of hemorrhagic cystitis after marrow transplantation [2].
Treatment of early cervical pregnancy with cerclage, carboprost, curettage, and balloon tamponade [6].
A response was prompted ultimately by a regimen consisting of continuous bladder irrigation and intermittent intravesical instillation of carboprost [9].
Following intramuscular injection of carboprost, plasma levels peaked after 20 minutes and declined slowly thereafter [10].

References

Prophylactic and therapeutic carboprost tromethamine bladder irrigation in rats with cyclophosphamide-induced hemorrhagic cystitis. Kranc, D.M., Kim, J., Straus, F., Levine, L.A. J. Urol. (1992) [Pubmed]
Intravesicular carboprost for the treatment of hemorrhagic cystitis after marrow transplantation. Ippoliti, C., Przepiorka, D., Mehra, R., Neumann, J., Wood, J., Claxton, D., Gajewski, J., Khouri, I., van Besien, K., Andersson, B. Urology (1995) [Pubmed]
Use of carboprost to facilitate hysteroscopic resection of submucous myomas. Indman, P.D. The Journal of the American Association of Gynecologic Laparoscopists. (2004) [Pubmed]
Major postpartum hemorrhage: survey of maternity units in the United Kingdom. Mousa, H.A., Alfirevic, Z. Acta obstetricia et gynecologica Scandinavica. (2002) [Pubmed]
Ovulatory response and embryo yield in Jakhrana goats following treatments with PMSG and FSH. Goel, A.K., Agrawal, K.P. Tropical animal health and production. (2005) [Pubmed]
Treatment of early cervical pregnancy with cerclage, carboprost, curettage, and balloon tamponade. De La Vega, G.A., Avery, C., Nemiroff, R., Marchiano, D. Obstetrics and gynecology (2007) [Pubmed]
Drug release testing of a prostaglandin containing controlled-release vaginal device: development of a semi-automated method. Halstead, G.W., Theis, D.L. Journal of pharmaceutical sciences. (1985) [Pubmed]
Second trimester abortion with ethacridine lactate plus carboprost--which is the best time to administer the carboprost? Malpani, A., Malpani, A., Krishna, U. Advances in contraception : the official journal of the Society for the Advancement of Contraception. (1988) [Pubmed]
Treatment of cyclophosphamide-induced hemorrhagic cystitis with prostaglandins. Miller, L.J., Chandler, S.W., Ippoliti, C.M. The Annals of pharmacotherapy. (1994) [Pubmed]
Pharmacokinetics of prostaglandins. Bygdeman, M. Best practice & research. Clinical obstetrics & gynaecology. (2003) [Pubmed]

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