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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Arctiin     4-[(3,4- dimethoxyphenyl)methyl]-3- [[3...

Synonyms:
 
 
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Disease relevance of Arctiin

  • Here, we examine the effect of arctiin, a lignan compound, on growth regulation in prostate cancer PC-3 cells [1].
  • Although the incidence of mammary carcinomas did not significantly differ among the PhIP-treated groups, multiplicity was significantly decreased in rats given 0.2 (0.7+/-0.7, P<0.05) or 0.02% (1.0+/-1.1, P<0.05) arctiin after PhIP initiation as compared with the PhIP alone controls (2.1+/-2.5) [2].
  • Histopathological evaluation of prostate revealed that all the rats in any group developed adenocarcinoma in dorsolateral lobe of prostate, except two rats in 0.1% arctiin treated and one rat in 0.002% arctiin treated groups without prostate adenocarcinoma development [3].
 

High impact information on Arctiin

  • We postulated that arctiin modulates the attachment/detachment of PC-3 cells and we investigated the role of arctiin on MUC-1 expression [1].
  • FACScan flow cytometric analysis demonstrated that arctiin increased the expression of the anti-adhesion mucin MUC-1, but did not affect integrin expression in PC-3 cells [1].
  • RESULTS: Treatment of PC-3 cells with arctiin decreased the cell number in a concentration- and time-dependent manner in serum-containing condition [1].
  • The arctiin-induced increase in MUC-1 protein expression was due to up-regulation of mRNA, as revealed by RT-PCR analysis [1].
  • Following an initial clean-up step on the AB-8 resin (polystyrene resin, 0.3-1.25 mm: NanKai Chemical Factory, Tianjin, China), high-speed counter-current chromatography (HSCCC) was used to purify an arctiin from an extract of the fruits of the Arctium lappa L [4].
 

Biological context of Arctiin

 

Anatomical context of Arctiin

  • These results indicate that arctiin has a protective effect on PhIP-induced carcinogenesis particularly in the mammary gland in the promotion period [2].
  • Pancreas acidophilic foci were induced in PhIP treated animals with slight decrease in the multiplicity with arctiin during the initiation phase [2].
 

Associations of Arctiin with other chemical compounds

  • These results indicated that the forsythia lignan, arctiin is effective on improving blood lipid status without a significant hepatotoxicity and is to be utilized for the functional foods for lipid-lowering action [6].
  • For liver carcinogenesis, groups of 15 male F344 rats were given a single intraperitoneal injection of diethylnitrosamine (DEN) and starting 2 weeks later, they were administered 0.03% MeIQx in the diet, MeIQx together with 0.5% arctiin, 0.1% arctiin or basal diet for 6 weeks [2].
  • In comparison with the UV and ESI-MS spectra and the HPLC retention time of authentic standards, the compounds were determined to be arctiin and arctigenin [7].
 

Gene context of Arctiin

  • Modulation of anti-adhesion molecule MUC-1 is associated with arctiin-induced growth inhibition in PC-3 cells [1].
  • Lack of significant modifying effect of arctiin on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats [3].
  • The numbers and areas of preneoplastic GST-P positive foci were elevated by the treatment with MeIQx, and further increased by the simultaneous treatment with arctiin [2].
 

Analytical, diagnostic and therapeutic context of Arctiin

  • A total of 64 male TG rats, 6 weeks old, were randomly divided to three experimental groups (soybean free Oriental MF diet with 0.1, 0.02, or 0.004% arctiin) and a control group (soybean free Oriental MF diet) [3].
  • Determination of arctiin and arctigenin in Fructus Arctii by reverse-phase HPLC [8].

References

  1. Modulation of anti-adhesion molecule MUC-1 is associated with arctiin-induced growth inhibition in PC-3 cells. Huang, D.M., Guh, J.H., Chueh, S.C., Teng, C.M. Prostate (2004) [Pubmed]
  2. Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats. Hirose, M., Yamaguchi, T., Lin, C., Kimoto, N., Futakuchi, M., Kono, T., Nishibe, S., Shirai, T. Cancer Lett. (2000) [Pubmed]
  3. Lack of significant modifying effect of arctiin on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Zeng, Y., Yokohira, M., Takeuchi, H., Saoo, K., Yamakawa, K., Matsuda, Y., Hosokawa, K., Li, J.Q., Ikeda, M., Imaida, K. Cancer Lett. (2005) [Pubmed]
  4. Application of preparative high-speed counter-current chromatography for separation and purification of arctiin from Fructus Arctii. Wang, X., Li, F., Sun, Q., Yuan, J., Jiang, T., Zheng, C. Journal of chromatography. A. (2005) [Pubmed]
  5. Structural transformation of lignan compounds in rat gastrointestinal tract; II. Serum concentration of lignans and their metabolites. Nose, M., Fujimoto, T., Nishibe, S., Ogihara, Y. Planta Med. (1993) [Pubmed]
  6. Effects of forsythia fruit extracts and lignan on lipid metabolism. Cho, S.H., Rhee, S.J., Choi, S.W., Choi, Y. Biofactors (2004) [Pubmed]
  7. Isolation and identification of arctiin and arctigenin in leaves of burdock (Arctium lappa L.) by polyamide column chromatography in combination with HPLC-ESI/MS. Liu, S., Chen, K., Schliemann, W., Strack, D. Phytochemical analysis : PCA. (2005) [Pubmed]
  8. Determination of arctiin and arctigenin in Fructus Arctii by reverse-phase HPLC. Sun, W.J., Sha, Z.F., Gao, H. Yao Xue Xue Bao (1992) [Pubmed]
 
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