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Chemical Compound Review

SureCN783051     (3E)-3- butylideneisobenzofuran-1-one

Synonyms: CHEMBL1765390, LS-2600, CHEBI:1240413, FEMA No. 3333, FT-0623332, ...
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High impact information on Butylidene phthalide


Biological context of Butylidene phthalide


Anatomical context of Butylidene phthalide

  • The total radioactivity, however, was decreased due to excretion into urine, and in the case of i.v.-administration, 80% of the administered butylidenephthalide was excreted into urine within 24 h, while only 5% was excreted into feces within 24 h [9].

Associations of Butylidene phthalide with other chemical compounds


Gene context of Butylidene phthalide


Analytical, diagnostic and therapeutic context of Butylidene phthalide


  1. Relaxant effects of butylidenephthalide in isolated dog blood vessels. Ko, W.C., Liao, C.C., Shih, C.H., Lei, C.B., Chen, C.M. Planta Med. (2002) [Pubmed]
  2. Screening, analysis and in vitro vasodilatation of effective components from Ligusticum Chuanxiong. Liang, M.J., He, L.C., Yang, G.D. Life Sci. (2005) [Pubmed]
  3. Acaricidal activity of butylidenephthalide identified in Cnidium officinale rhizome against dermatophagoides farinae and dermatophagoides pteronyssinus (Acari: Pyroglyphidae). Kwon, J.H., Ahn, Y.J. J. Agric. Food Chem. (2002) [Pubmed]
  4. Stereoselectivity of butylidenephthalide on voltage-dependent calcium channels in guinea-pig isolated ileum. Ko, W.C., Sheu, J.R., Leu, Y.R., Tzeng, S.H., Chen, C.M. J. Pharm. Pharmacol. (1997) [Pubmed]
  5. The selective antianginal effect without changing blood pressure of butylidenephthalide in conscious rats. Ko, W.C., Sheu, J.R., Tzeng, S.H., Chen, C.M. Planta Med. (1998) [Pubmed]
  6. A newly isolated antispasmodic--butylidenephthalide. Ko, W.C. Jpn. J. Pharmacol. (1980) [Pubmed]
  7. The structure-activity relationship between synthetic butylidenephthalide derivatives regarding the competence and progression of inhibition in primary cultures proliferation of mouse aorta smooth muscle cells. Mimura, Y., Kobayashi, S., Naitoh, T., Kimura, I., Kimura, M. Biol. Pharm. Bull. (1995) [Pubmed]
  8. Acaricidal activity of Cnidium officinale rhizome-derived butylidenephthalide against Tyrophagus putrescentiae (Acari: Acaridae). Kwon, J.H., Ahn, Y.J. Pest Manag. Sci. (2003) [Pubmed]
  9. Distribution, metabolism and excretion of butylidenephthalide of Ligustici chuanxiong rhizoma in hairless mouse after dermal application. Sekiya, K., Tezuka, Y., Tanaka, K., Prasain, J.K., Namba, T., Katayama, K., Koizumi, T., Maeda, M., Kondo, T., Kadota, S. Journal of ethnopharmacology. (2000) [Pubmed]
  10. Inhibitory effects of ligustilide and butylidenephthalide on bFGF-stimulated proliferation of rat smooth muscle cells. Liang, M.J., He, L.C. Yao Xue Xue Bao (2006) [Pubmed]
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