Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AG-G-89048 (5E,8E,11E,13E)-15- hydroxyicosa-5,8,11,13...

Synonyms: AR-1C0876, FT-0641489, AC1NS405, AC1Q5W03, 15-Hete, ...

Setty, B.N. et al., Hadjiagapiou, C. et al., Trautmann, M. et al., Turner, S.R. et al., Chang, J. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of 15-Hete

15-Hydroxy-5,8,11,13-eicosatetraenoic acid inhibits human vascular cyclooxygenase. Potential role in diabetic vascular disease [1].

High impact information on 15-Hete

Aspirin treatment of hPGHS-2 produced an enzyme which retained oxygenase activity but formed exclusively 15-hydroxy-5,8,11,13-eicosatetraenoic acid (15-HETE) instead of PGH2 [2].
MOLT-4 lymphocytes metabolize 15-hydroxy-5,8,11,13-eicosatetraenoic acid (15-HETE) via beta-oxidation with retention of the hydroxyl group at the omega 6-carbon atom [3].
Metabolism of 15-hydroxy-5,8,11,13-eicosatetraenoic acid by MOLT-4 cells and blood T-lymphocytes [3].
Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid [4].
Prostaglandin E2 (PGE2), PGD2 peptide leukotrienes and 15-hydroxy, 5,8,11,13-eicosatetraenoic acid (15-HETE) were measured by radioimmunoassay in nasal lavages [5].

Biological context of 15-Hete

Both 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) and 15-hydroxy-5,8,11,13-eicosatetraenoic acid (15-HETE) also inhibited platelet PLA2 activity (IC50 = 26 and 72 microM respectively) [6].

Anatomical context of 15-Hete

Gradients of 15-hydroxy-5,8,11,13-eicosatetraenoic acid (15-HETE) and 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid (15-HPETE) were significantly and equally chemotactic for human neutrophils at 15-75 microM [7].

Associations of 15-Hete with other chemical compounds

The effect of oral administration of various non-steroidal antiinflammatory drugs on ethanol-induced rat gastric injury and mucosal release of leukotriene C4, 6-keto-prostaglandin F1 alpha and 15-hydroxy-5,8,11,13-eicosatetraenoic acid was investigated [8].

References

15-Hydroxy-5,8,11,13-eicosatetraenoic acid inhibits human vascular cyclooxygenase. Potential role in diabetic vascular disease. Setty, B.N., Stuart, M.J. J. Clin. Invest. (1986) [Pubmed]
Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin. Lecomte, M., Laneuville, O., Ji, C., DeWitt, D.L., Smith, W.L. J. Biol. Chem. (1994) [Pubmed]
Metabolism of 15-hydroxy-5,8,11,13-eicosatetraenoic acid by MOLT-4 cells and blood T-lymphocytes. Hadjiagapiou, C., Travers, J.B., Fertel, R.H., Sprecher, H. J. Biol. Chem. (1990) [Pubmed]
Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid. Vanderhoek, J.Y., Bryant, R.W., Bailey, J.M. J. Biol. Chem. (1980) [Pubmed]
Release of chemical mediators and inflammatory cell influx during early allergic reaction in the nose: effect of furosemide. Prat, J., Mullol, J., Ramis, I., Roselló-Catafau, J., Xaubet, A., Nerin, I., Gelpí, E., Picado, C. J. Allergy Clin. Immunol. (1993) [Pubmed]
Inhibition of platelet and neutrophil phospholipase A2 by hydroxyeicosatetraenoic acids (HETES). A novel pharmacological mechanism for regulating free fatty acid release. Chang, J., Blazek, E., Kreft, A.F., Lewis, A.J. Biochem. Pharmacol. (1985) [Pubmed]
Non-chemokinetic neutrophil attractants derived from arachidonic acid. Turner, S.R., Tainer, J.A. Cell Biol. Int. Rep. (1983) [Pubmed]
Aspirin-like drugs, ethanol-induced rat gastric injury and mucosal eicosanoid release. Trautmann, M., Peskar, B.M., Peskar, B.A. Eur. J. Pharmacol. (1991) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.