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Chemical Compound Review

AC1L1GFO     diethyl-[3-(2- phenylheptanoyloxy) propyl]az...

Synonyms: LS-74412, C 2000, 78265-99-3
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Disease relevance of 3-diethylaminopropyl 2-phenylheptanoate

  • The Wza protein was shown previously to be required for the formation of the prototype group 1 capsule structure on the surface of Escherichia coli serotype K30 (Drummelsmith, J., and Whitfield, C. (2000) EMBO J. 19, 57-66) [1].

High impact information on 3-diethylaminopropyl 2-phenylheptanoate

  • This is a 16-bp deletion in the 5' region of a desaturase gene (desat2) that was recently suggested to be responsible for the CH polymorphism on the basis of its expression [Dallerac, R., Labeur, C., Jallon, J.-M., Knipple, D. C., Roelofs, W. L. & Wicker-Thomas, C. (2000) Proc. Natl. Acad. Sci. 97, 9449--9454] [2].
  • We have obtained transgenic mice expressing a neutralizing anti-NGF recombinant antibody, in which the levels of antibodies are three orders of magnitude higher in adult than in newborn mice [F.R., S. C. , A.C., E. Di Daniel, J. Franzot, S. Gonfloni, G. Rossi, N. B. & A. C. (2000) J. Neurosci., 20, 2589-2601] [3].
  • Because HERP1 appears to play a central role in the development of the aorta (Zhong, T. P., Rosenberg, M., Mohideen, M. A., Weinstein, B., and Fishman, M. C. (2000) Science 287, 1820-1824), we re-addressed the issue of its relationship with the Notch pathway by examining its expression in A10 smooth muscle cells derived from thoracic aorta [4].
  • LPS-induced TNF suppresses scavenger receptor functions in macrophages (van Lenten, B. J., and Fogelman, A. M. (1992) J. Immunol. 148, 112-116), which is regulated by TNF-mediated protein kinases (Hsu, H. Y., and Twu, Y. C. (2000) J. Biol. Chem. 275, 41035-41048) [5].
  • However, mutation of the single consensus cAMP-dependent protein kinase phosphorylation site (S334A) failed to modify the response of hIK1 to ATP (Gerlach, A. C., Gangopadhyay, N. N., and Devor, D. C. (2000) J. Biol. Chem. 275, 585-598) [6].

Biological context of 3-diethylaminopropyl 2-phenylheptanoate

  • Its turnover is controlled by an AU-rich element (ARE) localized in the 3'-untranslated region, since a reporter gene lacking this sequence was stable in the trypomastigote stage (Di Noia, J. M., D'Orso, I., Sanchez, D. O., and Frasch, A. C. (2000) J. Biol. Chem. 275, 10218-10227) [7].
  • TcUBP-1 recognizes the 44-nucleotide AU-rich RNA instability element located in the 3'-untranslated region of mucin SMUG mRNAs (Di Noia, J. M., D'Orso, I., Sanchez, D. O., and Frasch, A. C. (2000) J. Biol. Chem. 275, 10218-10227) as well as GU-rich sequences [8].
  • By contrast, the X-ray crystal structure of FXIII AP (28-37) displays all of the residues, P(10)-P(1), interacting with the thrombin active site in a conformation similar to that of fibrinogen Aalpha (7-16) [Sadasivan, C., and Yee, V. C. (2000) J. Biol. Chem. 275, 36942-36948] [9].

Anatomical context of 3-diethylaminopropyl 2-phenylheptanoate

  • Twenty-two subjects (10 with stage II and > or = 4 positive lymph nodes, and 12 with stage III disease) were treated with AC (A 60 mg/m2 and C 2000 mg/m2) with filgrastim every 14 days for three cycles followed by infusional paclitaxel (140 mg/m2 over 96 h) every 14 days for three cycles [10].
  • After 24 h of storage at 5 degrees C, 2000 mug/ml of gentamicin and levels equal to and greater than 1000 IU/ml of polymixin B in seminal extender resulted in significant (P<0.05) reductions in the percentages of motile and progressively motile spermatozoa [11].

Associations of 3-diethylaminopropyl 2-phenylheptanoate with other chemical compounds

  • A bridging oxygen moiety and two other hydroxide ligands were proposed to complete the ligation scheme (Brown, K., Tegoni, M., Prudencio, M., Pereira, A. S., Besson, S., Moura, J. J. G., Moura, I., and Cambillau, C. (2000) Nat. Struct. Biol. 7, 191-195) [12].


  1. Translocation of group 1 capsular polysaccharide in Escherichia coli serotype K30. Structural and functional analysis of the outer membrane lipoprotein Wza. Nesper, J., Hill, C.M., Paiment, A., Harauz, G., Beis, K., Naismith, J.H., Whitfield, C. J. Biol. Chem. (2003) [Pubmed]
  2. The nucleotide changes governing cuticular hydrocarbon variation and their evolution in Drosophila melanogaster. Takahashi, A., Tsaur, S.C., Coyne, J.A., Wu, C.I. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice. Capsoni, S., Ugolini, G., Comparini, A., Ruberti, F., Berardi, N., Cattaneo, A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. HERP1 is a cell type-specific primary target of Notch. Iso, T., Chung, G., Hamamori, Y., Kedes, L. J. Biol. Chem. (2002) [Pubmed]
  5. Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression. Hsu, H.Y., Wen, M.H. J. Biol. Chem. (2002) [Pubmed]
  6. ATP-dependent activation of the intermediate conductance, Ca2+-activated K+ channel, hIK1, is conferred by a C-terminal domain. Gerlach, A.C., Syme, C.A., Giltinan, L., Adelman, J.P., Devor, D.C. J. Biol. Chem. (2001) [Pubmed]
  7. Functionally different AU- and G-rich cis-elements confer developmentally regulated mRNA stability in Trypanosoma cruzi by interaction with specific RNA-binding proteins. D'Orso, I., Frasch, A.C. J. Biol. Chem. (2001) [Pubmed]
  8. TcUBP-1, a developmentally regulated U-rich RNA-binding protein involved in selective mRNA destabilization in trypanosomes. D'Orso, I., Frasch, A.C. J. Biol. Chem. (2001) [Pubmed]
  9. Thrombin activity is unaltered by N-terminal truncation of factor XIII activation peptides. Isetti, G., Maurer, M.C. Biochemistry (2004) [Pubmed]
  10. A pilot study of dose intense doxorubicin and cyclophosphamide followed by infusional paclitaxel in high-risk primary breast cancer. Zujewski, J.A., Eng-Wong, J., O'Shaughnessy, J., Venzon, D., Chow, C., Danforth, D., Kohler, D.R., Cusack, G., Riseberg, D., Cowan, K.H. Breast Cancer Res. Treat. (2003) [Pubmed]
  11. Effect of antibiotics on motion characteristics of cooled stallion spermatozoa. Jasko, D.J., Bedford, S.J., Cook, N.L., Mumford, E.L., Squires, E.L., Pickett, B.W. Theriogenology (1993) [Pubmed]
  12. Revisiting the catalytic CuZ cluster of nitrous oxide (N2O) reductase. Evidence of a bridging inorganic sulfur. Brown, K., Djinovic-Carugo, K., Haltia, T., Cabrito, I., Saraste, M., Moura, J.J., Moura, I., Tegoni, M., Cambillau, C. J. Biol. Chem. (2000) [Pubmed]
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