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Chemical Compound Review

Norzine     2-ethylsulfanyl-10-[3-(4- methylpiperazin-1...

Synonyms: Torecan, Tietilperazina, CHEMBL1378, SureCN49124, CHEBI:9544, ...
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Disease relevance of thiethylperazine


High impact information on thiethylperazine


Chemical compound and disease context of thiethylperazine

  • Promethazine (2 mg/kg), cimetidine (4 mg/kg), thiethylperazine (0.86 mg/kg), and naloxone (0.08 mg/kg) were each evaluated for their ability to increase the threshold of radiation-induced emesis in the dog [10].
  • Forty patients suffering from vertigo of different genesis received thiethylperazine 6.5 mg or meclizine 25 mg, 2 capsules a day for 5 days, according to double-blind, cross-over methodology in randomized order [11].

Biological context of thiethylperazine


Gene context of thiethylperazine

  • Three attacks of acute dystonia occurred in a 19-year-old male following the initiation and discontinuation of thiethylperazine administered rectally in therapeutic doses [12].
  • SETTING: The teratogenic potential of thiethylperazine was evaluated in the population-based large data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities between 1980 and 1996 [9].

Analytical, diagnostic and therapeutic context of thiethylperazine


  1. Migraine and drug absorption. Volans, G.N. Clinical pharmacokinetics. (1978) [Pubmed]
  2. Clinical evaluation of the simultaneous blockade of the dopamine D-2, histamine H-1, and muscarinic cholinergic receptors in cancer chemotherapy-induced emesis: results of a controlled trial. Martin-Jimenez, M., Diaz-Rubio, E. Cancer Chemother. Pharmacol. (1986) [Pubmed]
  3. Thiethylperazine and tardive dyskinesia. Sulkava, R. Acta neurologica Scandinavica. (1984) [Pubmed]
  4. Thiethylperazine-induced parkinsonism: in vivo demonstration of dopamine D2 receptors blockade. Briani, C., Cagnin, A., Chierichetti, F., Tiberio, M., Battistin, L., Pizzolato, G. Eur. J. Neurol. (2004) [Pubmed]
  5. Influence of age, renal and liver impairment on the pharmacokinetics of risperidone in man. Snoeck, E., Van Peer, A., Sack, M., Horton, M., Mannens, G., Woestenborghs, R., Meibach, R., Heykants, J. Psychopharmacology (Berl.) (1995) [Pubmed]
  6. Anaphylactic reaction and unrelated, subsequent, known side effects during therapy with thiethylperazine. Rossetti, G., Livio, F., Roulet, E., Hofer, M.F. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. (2005) [Pubmed]
  7. Thiethylperazine treatment of gastroparesis diabeticorum. Lossos, I.S., Mevorach, D., Oren, R. The Annals of pharmacotherapy. (1992) [Pubmed]
  8. The antiemetic efficacy of thiethylperazine and methylprednisolone versus thiethylperazine and placebo in breast cancer patients treated with adjuvant chemotherapy (fluorouracil, doxorubicin and cyclophosphamide). A randomized, double-blind, cross-over trial. Diaz-Rubio, E., Martin, M., Rosell, R., Valerdi, J.J., Gonzalez-Larriba, J.L., Barriga, J.J. Acta oncologica (Stockholm, Sweden) (1991) [Pubmed]
  9. Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug. Czeizel, A.E., Vargha, P. BJOG : an international journal of obstetrics and gynaecology. (2003) [Pubmed]
  10. Control of radiation-induced emesis with promethazine, cimetidine, thiethylperazine, or naloxone. Cooper, J.R., Mattsson, J.L. Am. J. Vet. Res. (1979) [Pubmed]
  11. Comparative investigation between thiethylperazine and meclizine in vertigo of different genesis. Jungert, S. Acta oto-rhino-laryngologica belgica. (1978) [Pubmed]
  12. Recurrent dystonic reactions induced by thiethylperazine. Khanderia, U. Drug intelligence & clinical pharmacy. (1985) [Pubmed]
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