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Chemical Compound Review

Antivert     1-[(4-chlorophenyl)-phenyl- methyl]-4-[(3...

Synonyms: Bonamine, Calmonal, Chiclida, Meclozine, meclizine, ...
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Disease relevance of Bonine


Psychiatry related information on Bonine


High impact information on Bonine


Chemical compound and disease context of Bonine


Biological context of Bonine

  • The resin-bound aryl triflate was shown to be stable to reductive amination conditions, and the traceless synthesis of Meclizine is reported [20].
  • High-affinity binding sites for [3H]MPTP may correspond to monamine oxidase [21].
  • A study of linkage disequilibrium between polymorphic loci for monamine oxidases A and B in schizophrenia [22].
  • The H1 antagonist, meclizine (25 mg/kg), was also effective against enterolobin oedema while the PAF-antagonists WEB 2086 and PCA 4248 (20 mg/kg) did not modify the reaction [23].
  • Various therapies (drugs, acupuncture, acupressure) were tried by 18% of the women with NVP, of which the majority used drugs, most notably antihistamines (specifically meclozine) [24].

Anatomical context of Bonine


Associations of Bonine with other chemical compounds


Gene context of Bonine

  • Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR [14].
  • Intraperitoneal administration of (-)-deprenyl (0.5-8 mg kg-1) produced a dose-dependent inhibition of striatal monoamine oxidase type B activity whereas monamine oxidase type A activity in the striatum was inhibited only by 8 mg kg-1 of (-)-deprenyl [34].
  • Immunostaining and in situ hybridization histochemistry reveal the presence of tyrosine hydroxylase (TH), DA transporter and vesicular monamine transporters in the acid-producing parietal cells [35].
  • Although our results confirmed previous data regarding changes in MAO A activity in brainstem and medulla oblongata, they did not confirm our hypothesis that the increase in monamine turnover and metabolites in the brain would be the result of increased MAO activity [36].
  • Presented data shows that HP in PH may be due to the presence of subclinical microadenoma made manifest by hypothyroid state and/or due to disturbances in monamine control of PRL and TSH secretion [37].

Analytical, diagnostic and therapeutic context of Bonine


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  3. Development of urinary retention during treatment with clozapine and meclizine. Cohen, M.A., Alfonso, C.A., Mosquera, M. The American journal of psychiatry. (1994) [Pubmed]
  4. Transdermal scopolamine, oral meclizine, and placebo in motion sickness. Dahl, E., Offer-Ohlsen, D., Lillevold, P.E., Sandvik, L. Clin. Pharmacol. Ther. (1984) [Pubmed]
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  7. The successful use of meclizine in panic disorder. Sansone, R.A., Sears, C.D. The Journal of clinical psychiatry. (2004) [Pubmed]
  8. Memory loss, confusion, and disorientation in an elderly woman taking meclizine. Molloy, D.W. Journal of the American Geriatrics Society. (1987) [Pubmed]
  9. Effects of adrenocorticotrophin-(4-10)-heptapeptide on changes in brain monamine metabolism associated with retrograde amnesia in the rat. Leonard, B.E., Ramaekers, F., Rigter, H. Biochem. Soc. Trans. (1975) [Pubmed]
  10. Direct sequencing of the reserpine-sensitive vesicular monamine transporter complementary DNA in unipolar depression and manic depressive illness. Lesch, K.P., Gross, J., Wolozin, B.L., Franzek, E., Bengel, D., Riederer, P., Murphy, D.L. Psychiatr. Genet. (1994) [Pubmed]
  11. The vesicular monoamine transporter 2 is present in small synaptic vesicles and preferentially localizes to large dense core vesicles in rat solitary tract nuclei. Nirenberg, M.J., Liu, Y., Peter, D., Edwards, R.H., Pickel, V.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  12. Covalent structure of the diheme cytochrome subunit and amino-terminal sequence of the flavoprotein subunit of flavocytochrome c from Chromatium vinosum. Van Beeumen, J.J., Demol, H., Samyn, B., Bartsch, R.G., Meyer, T.E., Dolata, M.M., Cusanovich, M.A. J. Biol. Chem. (1991) [Pubmed]
  13. Mitochondrial contact sites. Lipid composition and dynamics. Ardail, D., Privat, J.P., Egret-Charlier, M., Levrat, C., Lerme, F., Louisot, P. J. Biol. Chem. (1990) [Pubmed]
  14. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. Huang, W., Zhang, J., Wei, P., Schrader, W.T., Moore, D.D. Mol. Endocrinol. (2004) [Pubmed]
  15. Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats. Lavich, T.R., Cordeiro, R.S., Calixto, J.B., e Silva, P.M., Martins, M.A. Eur. J. Pharmacol. (2003) [Pubmed]
  16. Contribution of mast cells and snake venom metalloproteinases to the hyperalgesia induced by Bothrops jararaca venom in rats. Bonavita, A.G., da Costa, A.S., Pires, A.L., Neves-Ferreira, A.G., Perales, J., Cordeiro, R.S., Martins, M.A., e Silva, P.M. Toxicon (2006) [Pubmed]
  17. Auditory hallucinations elicited by combined meclizine and metaxalone use at bedtime. Kuykendall, J.R., Rhodes, R.S. The Annals of pharmacotherapy. (2004) [Pubmed]
  18. Pargyline-induced increase in serotonin levels: correlation with inhibition of lordosis in rats. Allen, D.L., Renner, K.J., Luine, V.N. Pharmacol. Biochem. Behav. (1993) [Pubmed]
  19. Treatment-resistant panic disorder. Bandelow, B., Rüther, E. CNS spectrums. (2004) [Pubmed]
  20. A traceless perfluoroalkylsulfonyl (PFS) linker for the deoxygenation of phenols. Pan, Y., Holmes, C.P. Org. Lett. (2001) [Pubmed]
  21. High-affinity binding sites for [3H]MPTP may correspond to monamine oxidase. Parsons, B., Rainbow, T.C. Eur. J. Pharmacol. (1984) [Pubmed]
  22. A study of linkage disequilibrium between polymorphic loci for monamine oxidases A and B in schizophrenia. Wei, J., Hemmings, G.P. Psychiatr. Genet. (1999) [Pubmed]
  23. Pro-inflammatory activity of enterolobin: a haemolytic protein purified from seeds of the Brazilian tree Enterolobium contortisiliquum. Castro-Faria-Neto, H.C., Martins, M.A., Bozza, P.T., Perez, S.A., Correa-Da-Silva, A.C., Lima, M.C., Cruz, H.N., Cordeiro, R.S., Sousa, M.V., Morhy, L. Toxicon (1991) [Pubmed]
  24. Relationship between vitamin use, smoking, and nausea and vomiting of pregnancy. Källén, B., Lundberg, G., Aberg, A. Acta obstetricia et gynecologica Scandinavica. (2003) [Pubmed]
  25. Role of mast cells in the development of pancreatitis-induced multiple organ dysfunction. Dib, M., Zhao, X., Wang, X.D., Andersson, R. The British journal of surgery. (2002) [Pubmed]
  26. The development of monamine-containing neurons in the brain and spinal cord of the salamander, Ambystoma mexicanum. Sims, T.J. J. Comp. Neurol. (1977) [Pubmed]
  27. Lipopolysaccharide-induced changes in monoamines in specific areas of the brain: blockade by interleukin-1 receptor antagonist. MohanKumar, S.M., MohanKumar, P.S., Quadri, S.K. Brain Res. (1999) [Pubmed]
  28. Central nervous system effects of meclizine and dimenhydrinate: evidence of acute tolerance to antihistamines. Manning, C., Scandale, L., Manning, E.J., Gengo, F.M. Journal of clinical pharmacology. (1992) [Pubmed]
  29. Hormone mediated changes in monoamine stores and regulation of enzymes of biosynthesis and metabolism in the rat adrenal gland. Influence of progesterone, estradiol, ACTH and testosterone administration. Bukhari, A.R., Guessab, A., Nicol, M.L. Steroids (1981) [Pubmed]
  30. Effects of systemic indomethacin, meclizine, and BW755C on chronic ultraviolet B-induced effects in hairless mouse skin. Kochevar, I.E., Moran, M., Lyon, N., Flotte, T., Siebert, E., Gange, R.W. J. Invest. Dermatol. (1993) [Pubmed]
  31. Endothelium- and beta-2 adrenoceptor-independent relaxation of rat aorta by tyramine and certain other phenylethylamines. Varma, D.R., Chemtob, S. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  32. Effects of adrenalectomy and adrenal steroids on norepinephrine synthesis and monamine oxidase activity. Dailey, J.W., Westfall, T.C. Eur. J. Pharmacol. (1978) [Pubmed]
  33. Determination of meclizine hydrochloride by ion-pair extraction with methyl orange. Hom, F.S., Ebert, W.R. Journal of pharmaceutical sciences. (1977) [Pubmed]
  34. Inhibition of monoamine oxidase-B by (-)-deprenyl potentiates neuronal responses to dopamine agonists but does not inhibit dopamine catabolism in the rat striatum. Paterson, I.A., Juorio, A.V., Berry, M.D., Zhu, M.Y. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  35. Dopamine produced by the stomach may act as a paracrine/autocrine hormone in the rat. Mezey, E., Eisenhofer, G., Hansson, S., Hunyady, B., Hoffman, B.J. Neuroendocrinology (1998) [Pubmed]
  36. Activities of monoamine oxidase (MAO) A and B in discrete regions of rat brain after rapid eye movement (REM) sleep deprivation. Perez, N.M., Benedito, M.A. Pharmacol. Biochem. Behav. (1997) [Pubmed]
  37. Monoamine regulation of prolactin and TSH secretion in hypothyroidism. Gerasimov, G., Chernova, T., Goncharov, N. Acta Med. Austriaca (1992) [Pubmed]
  38. Monoamine depletion blocks triazolam-induced phase advances of the circadian clock in hamsters. Penev, P.D., Zee, P.C., Turek, F.W. Brain Res. (1994) [Pubmed]
  39. Comparison of meclizine levels in the plasma of rats and dogs after intranasal, intravenous, and oral administration. Chovan, J.P., Klett, R.P., Rakieten, N. Journal of pharmaceutical sciences. (1985) [Pubmed]
  40. Naturally-occurring isoquinolines perturb monamine metabolism in the brain: studied by in vivo microdialysis. Maruyama, W., Nakahara, D., Dostert, P., Takahashi, A., Naoi, M. J. Neural Transm. Gen. Sect. (1993) [Pubmed]
  41. Pro- and anti-inflammatory activities of the latex from Calotropis procera (Ait.) R.Br. are triggered by compounds fractionated by dialysis. Alencar, N.M., Oliveira, J.S., Mesquita, R.O., Lima, M.W., Vale, M.R., Etchells, J.P., Freitas, C.D., Ramos, M.V. Inflamm. Res. (2006) [Pubmed]
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