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Chemical Compound Review

AC1NUSG4     3-hydroxypropanoate

Synonyms: CHEBI:16510, ZINC00895452, hydroxypropionate, 3-Hydroxypropanoate, 3-Hydroxypropionate, ...
This record was replaced with 68152.
 
 
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Disease relevance of beta-Lactic acid

  • The 3-hydroxypropionate cycle has been proposed as a new autotrophic CO(2) fixation pathway for the phototrophic green non-sulfur eubacterium Chloroflexus aurantiacus and for some chemotrophic archaebacteria [1].
  • Effects of fermentation conditions on the comonomer composition and its distribution of poly(3-hydroxybutyrate-co-3-hydroxypropionate) [P(3HB-co-3HP)] have been investigated for bacterial synthesis of P(3HB-co-3HP)s by Alcaligenes latus from sucrose and 3-hydroxypropionate (3HPA) mixed carbon sources [2].
  • This revealed elevated urinary excretion of the characteristics metabolites, 3-hydroxypropionate, 3-hydroxyisovalerate and methylcitrate, suggesting multiple carboxylase deficiency (MCD) [3].
 

High impact information on beta-Lactic acid

 

Chemical compound and disease context of beta-Lactic acid

 

Biological context of beta-Lactic acid

  • Bruchins, mono and bis (3-hydroxypropanoate) esters of long chain alpha,omega-diols, are a recently discovered class of insect elicitors that stimulate cell division and neoplasm formation when applied to pods of peas and certain other legumes [12].
  • The P(3HB-co-3HP) films could be degraded into 3HB and 3-hydroxypropionate (3HP) monomer at last, indicating that the catalytic domain of the enzyme recognized at least two monomeric units as substrates [13].
  • However, the isotopic results are not consistent with the degree of fractionation expected from either the 3-hydroxypropionate cycle or the reductive tricarboxylic acid cycle, suggesting that the microfossils studied did not use either of these pathways for carbon fixation [14].
 

Associations of beta-Lactic acid with other chemical compounds

 

Gene context of beta-Lactic acid

 

Analytical, diagnostic and therapeutic context of beta-Lactic acid

  • HPLC analysis of the mitochondrial incubation mixtures indicated that a single major metabolite, which coeluted with 3-hydroxypropionate, accumulated in the solution [19].

References

  1. Propionyl-coenzyme A synthase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO2 fixation. Alber, B.E., Fuchs, G. J. Biol. Chem. (2002) [Pubmed]
  2. Effect of dissolved oxygen concentration in the fermentation medium on transformation of the carbon sources during the biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxypropionate) by Alcaligenes latus. Wang, Y., Inoue, Y. Int. J. Biol. Macromol. (2001) [Pubmed]
  3. Holocarboxylase synthetase deficiency: report of a case with onset in late infancy. Touma, E., Suormala, T., Baumgartner, E.R., Gerbaka, B., Ogier de Baulny, H., Loiselet, J. J. Inherit. Metab. Dis. (1999) [Pubmed]
  4. A bicyclic autotrophic CO2 fixation pathway in Chloroflexus aurantiacus. Herter, S., Fuchs, G., Bacher, A., Eisenreich, W. J. Biol. Chem. (2002) [Pubmed]
  5. Properties of R-Citramalyl-Coenzyme A Lyase and Its Role in the Autotrophic 3-Hydroxypropionate Cycle of Chloroflexus aurantiacus. Friedmann, S., Alber, B.E., Fuchs, G. J. Bacteriol. (2007) [Pubmed]
  6. Malonyl-Coenzyme A Reductase in the Modified 3-Hydroxypropionate Cycle for Autotrophic Carbon Fixation in Archaeal Metallosphaera and Sulfolobus spp. Alber, B., Olinger, M., Rieder, A., Kockelkorn, D., Jobst, B., H??gler, M., Fuchs, G. J. Bacteriol. (2006) [Pubmed]
  7. Properties of succinyl-coenzyme A:D-citramalate coenzyme A transferase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus. Friedmann, S., Alber, B.E., Fuchs, G. J. Bacteriol. (2006) [Pubmed]
  8. Properties of succinyl-coenzyme A:L-malate coenzyme A transferase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus. Friedmann, S., Steindorf, A., Alber, B.E., Fuchs, G. J. Bacteriol. (2006) [Pubmed]
  9. Autotrophic CO(2) fixation by Chloroflexus aurantiacus: study of glyoxylate formation and assimilation via the 3-hydroxypropionate cycle. Herter, S., Farfsing, J., Gad'On, N., Rieder, C., Eisenreich, W., Bacher, A., Fuchs, G. J. Bacteriol. (2001) [Pubmed]
  10. Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation. Hügler, M., Menendez, C., Schägger, H., Fuchs, G. J. Bacteriol. (2002) [Pubmed]
  11. Phylogenetic and physiological characterization of a filamentous anoxygenic photoautotrophic bacterium ' Candidatus Chlorothrix halophila' gen. nov., sp. nov., recovered from hypersaline microbial mats. Klappenbach, J.A., Pierson, B.K. Arch. Microbiol. (2004) [Pubmed]
  12. Application of Bruchin B to pea pods results in the up-regulation of CYP93C18, a putative isoflavone synthase gene, and an increase in the level of pisatin, an isoflavone phytoalexin. Cooper, L.D., Doss, R.P., Price, R., Peterson, K., Oliver, J.E. J. Exp. Bot. (2005) [Pubmed]
  13. Enzymatic hydrolysis of bacterial poly(3-hydroxybutyrate-co-3-hydroxypropionate)s by poly(3-hydroxyalkanoate) depolymerase from Acidovorax Sp. TP4. Wang, Y., Inagawa, Y., Saito, T., Kasuya, K., Doi, Y., Inoue, Y. Biomacromolecules (2002) [Pubmed]
  14. Carbon isotopic composition of individual Precambrian microfossils. House, C.H., Schopf, J.W., McKeegan, K.D., Coath, C.D., Harrison, T.M., Stetter, K.O. Geology (2000) [Pubmed]
  15. Presence of acetyl coenzyme A (CoA) carboxylase and propionyl-CoA carboxylase in autotrophic Crenarchaeota and indication for operation of a 3-hydroxypropionate cycle in autotrophic carbon fixation. Menendez, C., Bauer, Z., Huber, H., Gad'on, N., Stetter, K.O., Fuchs, G. J. Bacteriol. (1999) [Pubmed]
  16. Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula. Carboxylating enzyme in the 3-hydroxypropionate cycle for autotrophic carbon fixation. Hügler, M., Krieger, R.S., Jahn, M., Fuchs, G. Eur. J. Biochem. (2003) [Pubmed]
  17. Occurrence, biochemistry and possible biotechnological application of the 3-hydroxypropionate cycle. Ishii, M., Chuakrut, S., Arai, H., Igarashi, Y. Appl. Microbiol. Biotechnol. (2004) [Pubmed]
  18. Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle. Strauss, G., Fuchs, G. Eur. J. Biochem. (1993) [Pubmed]
  19. Rate and route of oxidation of acrylic acid to carbon dioxide in rat liver. Finch, L., Frederick, C.B. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1992) [Pubmed]
 
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