The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1NUSG4     3-hydroxypropanoate

Synonyms: CHEBI:16510, ZINC00895452, hydroxypropionate, 3-Hydroxypropanoate, 3-Hydroxypropionate, ...
This record was replaced with 68152.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of beta-Lactic acid

  • The 3-hydroxypropionate cycle has been proposed as a new autotrophic CO(2) fixation pathway for the phototrophic green non-sulfur eubacterium Chloroflexus aurantiacus and for some chemotrophic archaebacteria [1].
  • Effects of fermentation conditions on the comonomer composition and its distribution of poly(3-hydroxybutyrate-co-3-hydroxypropionate) [P(3HB-co-3HP)] have been investigated for bacterial synthesis of P(3HB-co-3HP)s by Alcaligenes latus from sucrose and 3-hydroxypropionate (3HPA) mixed carbon sources [2].
  • This revealed elevated urinary excretion of the characteristics metabolites, 3-hydroxypropionate, 3-hydroxyisovalerate and methylcitrate, suggesting multiple carboxylase deficiency (MCD) [3].

High impact information on beta-Lactic acid


Chemical compound and disease context of beta-Lactic acid


Biological context of beta-Lactic acid

  • Bruchins, mono and bis (3-hydroxypropanoate) esters of long chain alpha,omega-diols, are a recently discovered class of insect elicitors that stimulate cell division and neoplasm formation when applied to pods of peas and certain other legumes [12].
  • The P(3HB-co-3HP) films could be degraded into 3HB and 3-hydroxypropionate (3HP) monomer at last, indicating that the catalytic domain of the enzyme recognized at least two monomeric units as substrates [13].
  • However, the isotopic results are not consistent with the degree of fractionation expected from either the 3-hydroxypropionate cycle or the reductive tricarboxylic acid cycle, suggesting that the microfossils studied did not use either of these pathways for carbon fixation [14].

Associations of beta-Lactic acid with other chemical compounds


Gene context of beta-Lactic acid


Analytical, diagnostic and therapeutic context of beta-Lactic acid

  • HPLC analysis of the mitochondrial incubation mixtures indicated that a single major metabolite, which coeluted with 3-hydroxypropionate, accumulated in the solution [19].


  1. Propionyl-coenzyme A synthase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO2 fixation. Alber, B.E., Fuchs, G. J. Biol. Chem. (2002) [Pubmed]
  2. Effect of dissolved oxygen concentration in the fermentation medium on transformation of the carbon sources during the biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxypropionate) by Alcaligenes latus. Wang, Y., Inoue, Y. Int. J. Biol. Macromol. (2001) [Pubmed]
  3. Holocarboxylase synthetase deficiency: report of a case with onset in late infancy. Touma, E., Suormala, T., Baumgartner, E.R., Gerbaka, B., Ogier de Baulny, H., Loiselet, J. J. Inherit. Metab. Dis. (1999) [Pubmed]
  4. A bicyclic autotrophic CO2 fixation pathway in Chloroflexus aurantiacus. Herter, S., Fuchs, G., Bacher, A., Eisenreich, W. J. Biol. Chem. (2002) [Pubmed]
  5. Properties of R-Citramalyl-Coenzyme A Lyase and Its Role in the Autotrophic 3-Hydroxypropionate Cycle of Chloroflexus aurantiacus. Friedmann, S., Alber, B.E., Fuchs, G. J. Bacteriol. (2007) [Pubmed]
  6. Malonyl-Coenzyme A Reductase in the Modified 3-Hydroxypropionate Cycle for Autotrophic Carbon Fixation in Archaeal Metallosphaera and Sulfolobus spp. Alber, B., Olinger, M., Rieder, A., Kockelkorn, D., Jobst, B., H??gler, M., Fuchs, G. J. Bacteriol. (2006) [Pubmed]
  7. Properties of succinyl-coenzyme A:D-citramalate coenzyme A transferase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus. Friedmann, S., Alber, B.E., Fuchs, G. J. Bacteriol. (2006) [Pubmed]
  8. Properties of succinyl-coenzyme A:L-malate coenzyme A transferase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus. Friedmann, S., Steindorf, A., Alber, B.E., Fuchs, G. J. Bacteriol. (2006) [Pubmed]
  9. Autotrophic CO(2) fixation by Chloroflexus aurantiacus: study of glyoxylate formation and assimilation via the 3-hydroxypropionate cycle. Herter, S., Farfsing, J., Gad'On, N., Rieder, C., Eisenreich, W., Bacher, A., Fuchs, G. J. Bacteriol. (2001) [Pubmed]
  10. Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation. Hügler, M., Menendez, C., Schägger, H., Fuchs, G. J. Bacteriol. (2002) [Pubmed]
  11. Phylogenetic and physiological characterization of a filamentous anoxygenic photoautotrophic bacterium ' Candidatus Chlorothrix halophila' gen. nov., sp. nov., recovered from hypersaline microbial mats. Klappenbach, J.A., Pierson, B.K. Arch. Microbiol. (2004) [Pubmed]
  12. Application of Bruchin B to pea pods results in the up-regulation of CYP93C18, a putative isoflavone synthase gene, and an increase in the level of pisatin, an isoflavone phytoalexin. Cooper, L.D., Doss, R.P., Price, R., Peterson, K., Oliver, J.E. J. Exp. Bot. (2005) [Pubmed]
  13. Enzymatic hydrolysis of bacterial poly(3-hydroxybutyrate-co-3-hydroxypropionate)s by poly(3-hydroxyalkanoate) depolymerase from Acidovorax Sp. TP4. Wang, Y., Inagawa, Y., Saito, T., Kasuya, K., Doi, Y., Inoue, Y. Biomacromolecules (2002) [Pubmed]
  14. Carbon isotopic composition of individual Precambrian microfossils. House, C.H., Schopf, J.W., McKeegan, K.D., Coath, C.D., Harrison, T.M., Stetter, K.O. Geology (2000) [Pubmed]
  15. Presence of acetyl coenzyme A (CoA) carboxylase and propionyl-CoA carboxylase in autotrophic Crenarchaeota and indication for operation of a 3-hydroxypropionate cycle in autotrophic carbon fixation. Menendez, C., Bauer, Z., Huber, H., Gad'on, N., Stetter, K.O., Fuchs, G. J. Bacteriol. (1999) [Pubmed]
  16. Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula. Carboxylating enzyme in the 3-hydroxypropionate cycle for autotrophic carbon fixation. Hügler, M., Krieger, R.S., Jahn, M., Fuchs, G. Eur. J. Biochem. (2003) [Pubmed]
  17. Occurrence, biochemistry and possible biotechnological application of the 3-hydroxypropionate cycle. Ishii, M., Chuakrut, S., Arai, H., Igarashi, Y. Appl. Microbiol. Biotechnol. (2004) [Pubmed]
  18. Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle. Strauss, G., Fuchs, G. Eur. J. Biochem. (1993) [Pubmed]
  19. Rate and route of oxidation of acrylic acid to carbon dioxide in rat liver. Finch, L., Frederick, C.B. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1992) [Pubmed]
WikiGenes - Universities