The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

SureCN1649697     (11R)-11-(4- dimethylaminophenyl)-17...

Synonyms: AC1L1M7Y
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on ZK 98299

  • The antiprogestins RU 486 and ZK 98299 do not promote binding of the progesterone receptor to this natural HRE in vivo, even at concentrations that completely inhibit the agonistic effects of potent synthetic progestins [1].
  • We show here that RU 486 and ZK 98299 have the same effects on receptor activation, dimerization, and binding to hormone responsive elements; differences in their action are explained by the 10-fold difference in their affinity for the receptor (ZK 98299 having the lower affinity) [2].
  • The inhibition of P4 action by OP increased the expression of Fas mRNA (P <0.01); however, it did not affect bax or bcl-2 mRNA expression (P >0.05) [3].
  • Moreover, OP stimulated expression of caspase-3 mRNA (P <0.01) [3].
  • Luteal cells obtained from the cows in the midluteal phase of the estrous cycle (Days 8-12 of the cycle) were exposed to a specific P4 antagonist (onapristone [OP], 10(-4) M) with or without 100 ng/ml Fas L [3].
 

Biological context of ZK 98299

 

Anatomical context of ZK 98299

 

Associations of ZK 98299 with other chemical compounds

  • These compounds were tested for their binding affinity to various steroid receptors and for their bio-activity in various animal models and the results were compared with those of RU38486 and ZK 98299 [7].
 

Gene context of ZK 98299

References

  1. Antiprogestins prevent progesterone receptor binding to hormone responsive elements in vivo. Truss, M., Bartsch, J., Beato, M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. In vivo evidence against the existence of antiprogestins disrupting receptor binding to DNA. Delabre, K., Guiochon-Mantel, A., Milgrom, E. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  3. Progesterone is a suppressor of apoptosis in bovine luteal cells. Okuda, K., Korzekwa, A., Shibaya, M., Murakami, S., Nishimura, R., Tsubouchi, M., Woclawek-Potocka, I., Skarzynski, D.J. Biol. Reprod. (2004) [Pubmed]
  4. Regulation of progesterone biosynthesis in the human placenta by estradiol 17 beta and progesterone. Shanker, Y.G., Rao, A.J. Biochem. Mol. Biol. Int. (1997) [Pubmed]
  5. Effect of epostane, ZK 98299, and ZK 98734 on the interruption of pregnancy in the rat. Snyder, B.W., Reel, J.R., Winneker, R.C., Batzold, F.H., Potts, G.O. Biol. Reprod. (1989) [Pubmed]
  6. Medroxyprogesterone acetate enhances in vivo and in vitro antibody production. Vermeulen, M., Pazos, P., Lanari, C., Molinolo, A., Gamberale, R., Geffner, J.R., Giordano, M. Immunology (2001) [Pubmed]
  7. Pharmacology of two new very selective antiprogestagens: Org 31710 and Org 31806. Kloosterboer, H.J., Deckers, G.H., Schoonen, W.G. Hum. Reprod. (1994) [Pubmed]
 
WikiGenes - Universities