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Chemical Compound Review

Kerecide     1-[(2R,4S,5R)-4-hydroxy-5...

Synonyms: Stoxil, idoxuridine, IUDR, Oftan-IDU, Allergan 211, ...
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Disease relevance of idoxuridine

  • Immunization with cPZP and adjuvant produced moderate to high titers of antizona antibodies and infertility [1].
  • Antizona and antisperm antibodies in women with endometriosis and/or infertility [2].
  • Significant dose-, but not time-dependent, toxicity was observed at the clinical concentrations of IDU, TFT, and EDU [3].
  • The selection of ACV and IDU resistant mutants was performed on a cloned sensitive HSV 1 ocular strain [4].

High impact information on idoxuridine


Biological context of idoxuridine

  • In a group of 50 randomly selected mares tested for antizona antibodies, 2 pregnant mares were found to be positive, one at 60 and the other at 90 days of gestation [8].

Anatomical context of idoxuridine

  • In separate experiments confluent corneal epithelial cell monolayers were inoculated with 10(4) plaque forming units (PFU) of HSV type 1 (McKrae strain) for 1 h, and IDU 0.1%, TFT 1.0%, and BVDU 0.1% were added to the culture for determination of PFU inhibition [3].

Analytical, diagnostic and therapeutic context of idoxuridine


  1. Fertility control in the bitch by active immunization with porcine zonae pellucidae: use of different adjuvants and patterns of estradiol and progesterone levels in estrous cycles. Mahi-Brown, C.A., Yanagimachi, R., Hoffman, J.C., Huang, T.T. Biol. Reprod. (1985) [Pubmed]
  2. Antizona and antisperm antibodies in women with endometriosis and/or infertility. Szczepañska, M., Skrzypczak, J., Kamieniczna, M., Kurpisz, M. Fertil. Steril. (2001) [Pubmed]
  3. An in vitro study of ophthalmic antiviral agent toxicity on rabbit corneal epithelium. Imperia, P.S., Lazarus, H.M., Dunkel, E.C., Pavan-Langston, D., Geary, P.A., Lass, J.H. Antiviral Res. (1988) [Pubmed]
  4. A rapid and automated colorimetric assay for evaluating the sensitivity of herpes simplex strains to antiviral drugs. Langlois, M., Allard, J.P., Nugier, F., Aymard, M. Journal of biological standardization. (1986) [Pubmed]
  5. Effect of iontophoretic and topical application of antiviral agents in treatment of experimental HSV-1 keratitis in rabbits. Kwon, B.S., Gangarosa, L.P., Park, N.H., Hull, D.S., Fineberg, E., Wiggins, C., Hill, J.M. Invest. Ophthalmol. Vis. Sci. (1979) [Pubmed]
  6. Immunity to zona pellucida in women with low response to ovarian stimulation, in unexplained infertility and after multiple IVF attempts. Hovav, Y., Almagor, M., Benbenishti, D., Margalioth, E.J., Kafka, I., Yaffe, H. Hum. Reprod. (1994) [Pubmed]
  7. Assessment of the relevance of zona pellucida antibodies in serum and cervical mucus in patients who have fertilization failure during in vitro fertilization. Curtis, P., Burford, G., Amso, N., Keith, E., Shaw, R.W. Fertil. Steril. (1991) [Pubmed]
  8. Inhibition of sperm binding to porcine ova by antibodies to equine zonae pellucidae. Shivers, C.A., Liu, I.K. J. Reprod. Fertil. Suppl. (1982) [Pubmed]
  9. Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy. Autoantibodies. Tung, K.S., Smith, S., Matzner, P., Kasai, K., Oliver, J., Feuchter, F., Anderson, R.E. Am. J. Pathol. (1987) [Pubmed]
  10. Immunological interference with fertilization. Shivers, C.A. Acta endocrinologica. Supplementum. (1975) [Pubmed]
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