Disease relevance of idoxuridine

• Immunization with cPZP and adjuvant produced moderate to high titers of antizona antibodies and infertility [1].
• Antizona and antisperm antibodies in women with endometriosis and/or infertility [2].
• Significant dose-, but not time-dependent, toxicity was observed at the clinical concentrations of IDU, TFT, and EDU [3].
• The selection of ACV and IDU resistant mutants was performed on a cloned sensitive HSV 1 ocular strain [4].

High impact information on idoxuridine

• Topical IDU (0.5%) or Ara-AMP (10%) also significantly improved the disease process when compared to the placebo-treated group; however, iontophoresis of Ara-AMP resulted in a more marked improvement [5].
• In women with unexplained infertility, a high degree of correlation (Spearman) was found between the presence of antizona antibodies in peritoneal fluid and serum (r = 0.579) [2].
• A positive predictive value of 80% was calculated for the presence of antizona antibodies (>5 ng/oocyte) in the peritoneal fluid of patients with infertility [2].
• A retrospective study was designed to assess the presence of antizona pellucida autoantibodies in in-vitro fertilization (IVF) patients in relation to low ovarian response, multiple IVF attempts and unexplained infertility [6].
• MAIN OUTCOME MEASURES: The presence of antizona pellucida antibodies in serum or cervical mucus in relation to fertilization [7].

Biological context of idoxuridine

• In a group of 50 randomly selected mares tested for antizona antibodies, 2 pregnant mares were found to be positive, one at 60 and the other at 90 days of gestation [8].

Anatomical context of idoxuridine

• In separate experiments confluent corneal epithelial cell monolayers were inoculated with 10(4) plaque forming units (PFU) of HSV type 1 (McKrae strain) for 1 h, and IDU 0.1%, TFT 1.0%, and BVDU 0.1% were added to the culture for determination of PFU inhibition [3].

Analytical, diagnostic and therapeutic context of idoxuridine

• Serum antizona antibodies, but not anti-oocyte antibodies, inhibited mouse fertilization in vitro [9].
• Three of 10 patients with low response to ovarian stimulation had antizona pellucida antibodies in serum and one patient had antisperm antibodies [6].
• The median values for antizona and antisperm antibodies in peritoneal fluid were significantly higher in women with idiopathic infertility than in the control group [2].
• Passive immunization of female mice with antizona antibodies and precipitattion of the zonae of hamster embryos in transfer experiments reduced the number of implantation sites [10].

References