Disease relevance of DIGLYCIDYL ETHER

• Dermatitis from phenyl glycidyl ether [1].
• Allergic contact dermatitis from the epoxy resin plasticizer diglycidyl ether of propylene glycol [2].
• Synthesis of the four optical isomers of TZC-5665 (1), a candidate for the treatment of congestive heart failure, was achieved by the reaction of chiral diaminopyridazinone (2) with chiral glycidyl ether [3].

High impact information on DIGLYCIDYL ETHER

• Analysis of the DNA adducts of phenyl glycidyl ether in a calf thymus DNA hydrolysate by capillary zone electrophoresis-electrospray mass spectrometry: evidence for phosphate alkylation [4].
• Three triblock copolymers of ethylene oxide and phenyl glycidyl ether, type E(m)G(n)E(m), where G = OCH2CH(CH2OC6H5) and E = OCH2CH2, were synthesized and characterized by gel-permeation chromatography, matrix-assisted laser desorption ionization time-of-flight mass spectrometry, and NMR spectroscopy [5].
• Analysis of the DNA damage induced by phenyl glycidyl ether using capillary zone electrophoresis-electrospray mass spectrometry [6].
• The assays are applicable to whole tissue homogenates as well as purified enzyme preparations. p-Nitrostyrene oxide and p-nitrophenyl glycidyl ether were also examined and found to be very poor substrates for cytosolic epoxide hydrolase from mouse liver [7].
• Cytotoxic effects of BADGE (bisphenol A diglycidyl ether) and BFDGE (bisphenol F diglycidyl ether) on Caco-2 cells in vitro [8].

Biological context of DIGLYCIDYL ETHER

• 2,3-Dihydroxypropyl glycidyl ether (III) may be formed either by hydrolysis of I or epoxidation of II [9].
• Biotransformations of the glycidyl ether and their likely biochemical mechanisms are discussed [10].
• Sensitizing capacity and cross-reaction pattern of the isomers of diglycidyl ether of bisphenol F in the guinea pig [11].

Anatomical context of DIGLYCIDYL ETHER

• To address these deficiencies, we undertook the development of a biological valved conduit: a bovine external jugular vein graft with a retained native valve cross-linked with a diglycidyl ether (DE) [12].

Associations of DIGLYCIDYL ETHER with other chemical compounds

• A reversed phase high performance liquid chromatographic method combined with fluorescence and mass spectrometric detection in series is presented for the separation and quantification of bisphenol A diglycidyl ether (BADGE) and novolac glycidyl ether (NOGE) derivatives in extracts from food can coatings, tuna and oil [13].

Gene context of DIGLYCIDYL ETHER

• Harvested bovine vein containing a naturally existing valve was initially incorporated with protamine on the inner surface and then was cross-linked in diglycidyl ether (DE) [14].

References