Disease relevance of Ozolinone

• The results suggest that acute hepatitis and hepatic cirrhosis lead to a reduced formation of ozolinone [1].
• Altered kinetics of etozolin and its active metabolite ozolinone in hepatitis and hepatic cirrhosis with ascites [1].

High impact information on Ozolinone

• The plasma half-life of etozolin and ozolinone are 2 and 10 hours, respectively [2].
• Both ozolinone enantiomers markedly increased the renal blood flow and decreased the filtration fraction, suggesting that the vosodilating effect predominates on the efferent glomerular arterioles [3].
• Mechanisms of ozolinone-induced renin release and diuresis [4].
• Dextrorotatory (+) and levorotatory (-) ozolinone (ozo) were injected directly into the left renal artery of volume-expanded anesthetized dogs [4].
• The effect of the non-diuretic dextrorotatory isomer of ozolinone on l- ozolinone -induced diuresis was studied in anesthetized rats [5].

Biological context of Ozolinone

• Like furosemide, ozolinone increased renal blood flow, slightly decreased glomerular filtration rate, depressed tubular chloride reabsorption more than sodium reabsorption, increased potassium excretion, lowered the pH of urine, decreased urinary osmolarity towards isotonicity and depressed tubular PAH secretion [6].
• Placental transfer of etozolin and ozolinone during the first half of gestation in man [7].
• At the same time, plasma levels of ozolinone were lower and consequently the AUC of his metabolite was reduced [1].

Anatomical context of Ozolinone

• The effects of the diuretic drug ozolinone on electrogenic Cl- secretion by rabbit colonic mucosa were investigated in vitro [8].

Associations of Ozolinone with other chemical compounds

• The effect of the non-diuretic dextrorotatory isomer of ozolinone on furosemide-induced diuresis was studied by means of clearance and micropuncture techniques in rats [9].
• By employing the enantiomeres of the new loop diuretic ozolinone, non-stereospecific increase in renal blood flow and inhibition of tubular secretion of p-aminohippurate and urate were found [10].

Analytical, diagnostic and therapeutic context of Ozolinone

• Effects of ozolinone, a diuretic active metabolite of etozoline, on renal function. II. Localization of tubular site of diuretic action by micropuncture in the rat [11].
• However, both isomers of ozolinone equally inhibited maximal tubular secretion of paraaminohippurate and increased renal blood flow as measured by an electromagnetic flowmeter [12].

References