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Chemical Compound Review

Edoxudin     5-ethyl-1-[(2R,4S,5R)-4- hydroxy-5...

Synonyms: Aedurid, Edoxudina, Epoxudine, edoxudine, Edoxudinum, ...
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Disease relevance of edoxudine


High impact information on edoxudine


Chemical compound and disease context of edoxudine


Anatomical context of edoxudine


Gene context of edoxudine

  • The solution conformation of 5-ethyl-2'-deoxyuridine (EDU) has been calculated from the vicinyl proton-proton NMR coupling constants and nuclear Overhauser (NOE) distances using excitation sculpting of selective pulses (Double Pulsed Field Gradient Spin Echo NOE) at 500 MHz and molecular modelling (PM3) studies [11].

Analytical, diagnostic and therapeutic context of edoxudine


  1. Specific phosphorylation of 5-ethyl-2'-deoxyuridine by herpes simplex virus-infected cells and incorporation into viral DNA. De Clercq, E., Bernaerts, R. J. Biol. Chem. (1987) [Pubmed]
  2. Effect of treatment with 5-ethyl-2'-deoxyuridine on herpes simplex virus encephalitis in normal and immunosuppressed mice. Davis, W.B., Oakes, J.E., Taylor, J.A. Antimicrob. Agents Chemother. (1978) [Pubmed]
  3. Antiviral activity of 5-ethyl-2'-deoxyuridine against herpes simplex viruses in cell culture, mice, and guinea pigs. Schinazi, R.F., Scott, R.T., Peters, J., Rice, V., Nahmias, A.J. Antimicrob. Agents Chemother. (1985) [Pubmed]
  4. Antitumor cell and antimetabolic effects of 5-ethyl-2'-deoxyuridine and 5'-substituted 5-ethyl-2'-deoxyuridine derivatives. Balzarini, J., De Clercq, E., Kiefer, G., Keppeler, K., Buchele, A. Investigational new drugs. (1984) [Pubmed]
  5. Induction and inhibition of Friend erythroleukemia cell differentiation by pyrimidine analogs: analysis of the requirement for intracellular accumulation and incorporation into DNA. Bilello, J.A., Gauri, K.K., Kühne, J., Warnecke, G., Koch, G. Mol. Cell. Biol. (1982) [Pubmed]
  6. Pharmacokinetics and bioavailability of 5-ethyl-2'-deoxyuridine and its novel (5R,6R)-5-bromo-6-ethoxy-5,6-dihydro prodrugs in mice. Cheraghali, A.M., Kumar, R., Knaus, E.E., Wiebe, L.I. Drug Metab. Dispos. (1995) [Pubmed]
  7. High-performance liquid chromatographic analysis of 5-ethylpyrimidines and 5-methylpyrimidines in plasma. Joly, J.M., Williams, W.M. J. Chromatogr. (1991) [Pubmed]
  8. Modulation of 5-fluorouracil by 5-ethyl-2'-deoxyuridine on cell lines expressing different dihydropyrimidine dehydrogenase activities. Katona, C., Tímár, F., Jeney, A., Fischel, J.L., Milano, G., Pandi, E., Kralovánszky, J. Anticancer Drugs (1999) [Pubmed]
  9. Comparison of topically applied 5-ethyl-2'-deoxyuridine and acyclovir in the treatment of cutaneous herpes simplex virus infection in guinea pigs. Spruance, S.L., Freeman, D.J., Sheth, N.V. Antimicrob. Agents Chemother. (1985) [Pubmed]
  10. 5-Ethyl-2'-deoxyuridine. Cytotoxicity and DNA incorporation demonstrated with human leukemic cells and PHA-stimulated lymphocytes in vitro. Tuominen, H., Bergstrom, D., Vilpo, J.A. Acta Chem. Scand., B, Org. Chem. Biochem. (1985) [Pubmed]
  11. Structural studies of 5-ethyl-2'-deoxyuridine by selective pulse 1H DPFGSE NOE spectroscopy and PM3 calculations. Bailey, L.E., García-Martín, M.L., Stender, H., Ball, G. Nucleosides Nucleotides (1999) [Pubmed]
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