The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Nicometh     methyl pyridine-3-carboxylate

Synonyms: Nikomet, PubChem11724, SureCN24566, AGN-PC-006I4G, CHEMBL379845, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Nicometh

 

Psychiatry related information on Nicometh

 

High impact information on Nicometh

  • The release of PGD2 in response to topically applied methylnicotinate occurred in a dose-dependent manner over the concentration range of 10(-3) to 10(-1) M [1].
  • A single application of 1% Evodia biomimetic mixture also significantly inhibited MN-induced erythema when applied at 60 min before, or within 5 min after MN exposure [6].
  • This was tested for anti-inflammatory activity in UVB-irradiated cultured cells and in the MN model of micro-inflammation in human skin [6].
  • We found that MN also induces release of nitric oxide from cultured keratinocytes and microvascular endothelial cells [6].
  • Vasodilation induced by methylnicotinate, a fatty acid- and cyclooxygenase-dependent process, is reduced or absent in patients with schizophrenia [7].
 

Chemical compound and disease context of Nicometh

 

Biological context of Nicometh

 

Analytical, diagnostic and therapeutic context of Nicometh

References

  1. Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans. Morrow, J.D., Awad, J.A., Oates, J.A., Roberts, L.J. J. Invest. Dermatol. (1992) [Pubmed]
  2. Reduced vasodilatory response to methylnicotinate in schizophrenia as assessed by laser Doppler flowmetry. Ross, B.M., Hughes, B., Turenne, S., Seeman, M., Warsh, J.J. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (2004) [Pubmed]
  3. Formulation study and anti-inflammatory efficacy of topical semi-solids containing a nitro ester of flurbiprofen. Minghetti, P., Casiraghi, A., Cilurzo, F., Tosi, L., Montanari, L., Trespidi, L. Skin Pharmacol. Appl. Skin Physiol. (2003) [Pubmed]
  4. Effects of local hyperemia and edema on the biological zero in laser Doppler fluxmetry (LD). Wahlberg, E., Olofsson, P., Swedenborg, J., Fagrell, B. International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation. (1992) [Pubmed]
  5. Delayed vasodilatory response to methylnicotinate in patients with unipolar depressive disorder. Ross, B.M., Ward, P., Glen, I. Journal of affective disorders. (2004) [Pubmed]
  6. Anti-inflammatory activity in skin by biomimetic of Evodia rutaecarpa extract from traditional Chinese medicine. Yarosh, D.B., Galvin, J.W., Nay, S.L., Peña, A.V., Canning, M.T., Brown, D.A. J. Dermatol. Sci. (2006) [Pubmed]
  7. On the relationship between methylnicotinate-induced skin flush and fatty acids levels in acute psychosis. Maclean, R., Ward, P.E., Glen, I., Roberts, S.J., Ross, B.M. Prog. Neuropsychopharmacol. Biol. Psychiatry (2003) [Pubmed]
  8. Release of markedly increased quantities of prostaglandin D2 from the skin in vivo in humans following the application of sorbic acid. Morrow, J.D., Minton, T.A., Awad, J.A., Roberts, L.J. Archives of dermatology. (1994) [Pubmed]
  9. Determination of the in vivo bioavailability of iontophoretically delivered diclofenac using a methyl nicotinate skin inflammation assay. Lambrecht, R., Clarys, P., Clijsen, R., Barel, A.O. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). (2006) [Pubmed]
  10. Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema. Covault, J., Pettinati, H., Moak, D., Mueller, T., Kranzler, H.R. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2004) [Pubmed]
 
WikiGenes - Universities