Disease relevance of Evodia

• Previous investigations have indicated that the pharmacological activities of evodiamine, a major alkaloidal component of the dried, unripe fruit of Evodia rutaecarpa Bentham (Rutaceae), are associated with the stimulation of calcitonin gene-related peptide (CGRP) release and that CGRP protects the myocardium against ischemia-reperfusion injury [1].
• Twice daily application of 0.1-1% Evodia biomimetic mixture for 2 weeks significantly inhibited erythema after a MN challenge [2].
• HIV inhibitory natural products. 26. Quinoline alkaloids from Euodia roxburghiana [3].
• Methanol extract from a Chinese medicine, evodia (fruits of Evodia rutaecarpa Benth. or E. officinalis Dode), had a significant effect in the KCN-induced anoxia model in mice and therefore the active constituents were further examined [4].
• Like Evodiae fructus, a muscarinic acetylcholine receptor antagonist atropine inhibited castor oil-induced increase in fecal weight and loss of body weight [5].

High impact information on Evodia

• Evodiamine, an alkaloidal component extracted from the fruit of Evodiae fructus (Evodia rutaecarpa Benth., Rutaceae), exhibits antiproliferative, antimetastatic, and apoptotic activities through a poorly defined mechanism [6].
• Rutaecarpine is the main active alkaloid of the herbal medicine, Evodia rutaecarpa [7].
• New indole N-oxide alkaloids from Evodia fargesii [8].
• The cell to medium ratio of [3H]digoxin accumulation increased significantly in the presence of the decoction of Evodiae fructus, Aurantii nobilis pericarpium, and Zanthoxyli fructus, and the ethyl acetate fraction of all citrus herbs used [9].
• The caffeine level was significantly decreased by the pretreatment of rutaecarpine, the extract of Evodia rutaecarpa and herbal preparation Wu-Chu-Yu-Tang [10].

Chemical compound and disease context of Evodia

• The Evodia biomimetic mixture was significantly more effective at inhibiting erythema than bisabolol, the active component of chamomile [2].

Biological context of Evodia

• Mechanism of inhibition of platelet aggregation by rutaecarpine, an alkaloid isolated from Evodia rutaecarpa [11].
• Evodiamine, a characteristic alkaloid extracted from Evodia fruits, has been reported to exhibit inhibitory effect on cell proliferation and migration in several types of cancer cells [12].
• Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa, in rats [13].
• We further studied the effect of Evodia fruit alkaloid hydroxyevodiamine, evodiamine, rutaecarpine and evocarpine used individually and confirmed that the body temperature retaining effect occurred mainly with evodiamine [14].
• Evocarpine, an isoquinolone alkaloid isolated from the fruit of Evodia rutaecarpa, was found to induce apoptotic cell death in promyelocytic leukaemia HL-60 cells in dose- and time-dependent manners [15].

Anatomical context of Evodia

• The n-hexane extract of the fruits of Evodia rutaecarpa showed a considerable inhibiting effect on leukotriene biosynthesis in human granulocytes [16].
• In vitro relaxation of rabbit and human internal anal sphincter by rutaecarpine, an alkaloid isolated from Evodia rutaecarpa [17].
• The vasoreactivity of dehydroevodiamine (1), evodiamine (2), and rutaecarpine (3), quinazoline alkaloids isolated from Evodia rutaecarpa, to aorta smooth muscle demonstrated that they produce a vasodilatory effect on endothelium-intact rat aorta with equal potency [18].

Associations of Evodia with chemical compounds

• Antithrombotic effect of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, on platelet plug formation in in vivo experiments [19].
• The effect of evocarpine (EVO), a quinolone alkaloid isolated from Evodiae fructus, on Ca2+-blocking activity has been examined [20].
• Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist [21].
• Atanine (3-dimethylallyl-4-methoxy-2-quinolone), an alkaloid with anthelmintic activity from the Chinese medicinal plant, Evodia rutaecarpa [22].
• It is known that when methanol extract of Evodia fruit is orally administered, 5-(1,4-dihydro-1-methyl-4-oxo-2-quinolin-2-yl) pentanoic acid (EVCA) is excreated as a matabolite in rat urine [23].

Gene context of Evodia

• A new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpa [24].
• Mechanism-based inactivation of human liver microsomal CYP3A4 by rutaecarpine and limonin from Evodia fruit extract [25].
• The effect of "chi-han (hot nature)" Chinese herbs on the secretion of the cytokines IL-1 beta and TNF-alpha was investigated by studying the in vitro effect of the "hot nature" Chinese herbs Radix aconiti, Evodia rutaecarpa, Zingiberis rhizoma, and Cortex cinnamomi [26].
• Induction of cytochrome P450-dependent monooxygenase in mouse liver and kidney by rutaecarpine, an alkaloid of the herbal drug Evodia rutaecarpa [27].
• This study suggests that Evodiae fructus extracts can be used as a possible therapy for alcohol-induced hangover symptoms by stimulating the expression of hepatic alcohol metabolizing and antioxidant enzymes [28].

Analytical, diagnostic and therapeutic context of Evodia

• Rutaecarpine, evodiamine, and dehydroevodiamine are quinazolinocarboline alkaloids isolated from a traditional Chinese medicine, Evodia rutaecarpa [29].
• Alcohol concentrations were the lowest in all of the Evodiae fructus treatment groups, as well as one (10 mL/kg-bw) of the positive control groups, 4h after ethanol exposure (0-5mg/dL and 60-110 mg/dL for 20% and 40% ethanol-loaded mice, respectively) [28].

References