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Chemical Compound Review

C11202     (6R,7R)-3-[(4-aminocarbonyl- 1...

Synonyms:
 
 
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Disease relevance of C11202

 

High impact information on C11202

  • In Pseudomonas aeruginosa, resistance to cefclidin is usually associated with resistance to another third-generation cephalosporin, ceftazidime [5].
  • Of the compounds tested, cefclidin showed the lowest affinity for these enzymes, suggesting that its high activity against P. aeruginosa resistant to several beta-lactams was mainly due to its high resistance to enzymatic hydrolysis [6].
  • Cefclidin had lower affinity and a higher Vmax value for the chromosomal type I beta-lactamase (cephalosporinase) from P. aeruginosa than its aminothiazolyl counterpart [7].
  • The rate of survival of biofilm bacteria was higher than that of floating bacteria in contact with twice the minimal bactericidal concentration of ciprofloxacin (CPFX) or two to 10 times the minimal inhibitory concentration of cefclidin and meropenem which are highly potent antibacterial agents against P. aeruginosa [8].
  • Pharmacological effects of cefclidin on the central nervous system [9].
 

Anatomical context of C11202

  • Patch testing with cefclidin produced a +/- reaction in 1 of 8 cases, and the drug-induced lymphocyte stimulation test (DLST) elicited a positive response (SI: 2.8) in 1 of 8 and a weakly positive response (1.8 < or = SI < 2) in 2 of 8 [3].
 

Associations of C11202 with other chemical compounds

 

Analytical, diagnostic and therapeutic context of C11202

References

  1. In vitro and in vivo activities of DQ-2556 and its mode of action. Tanaka, M., Otsuki, M., Nishino, T. Antimicrob. Agents Chemother. (1992) [Pubmed]
  2. Bactericidal activity of cefclidin (E1040) against Pseudomonas aeruginosa under conditions simulating plasma pharmacokinetics: lack of development of chromosomally-mediated resistance to beta-lactams. Watanabe, N., Katsu, K. J. Antimicrob. Chemother. (1992) [Pubmed]
  3. Enhancing effects of fluorescein on beta-lactam rash. I: High incidence of cefclidin rashes in an ophthalmological volunteer trial. Tone, T., Ikezawa, Z., Nishioka, K., Aoki, S., Miyata, M. J. Dermatol. (1992) [Pubmed]
  4. Enhancing effects of fluorescein on beta-lactam rash. II: Enhancing effects of fluorescein on generalized rash induced by beta-lactam antibiotics in guinea pigs. Ikezawa, Z., Sugihara, Y., Ueno, J. J. Dermatol. (1992) [Pubmed]
  5. Detection of OXA-4 beta-lactamase in Pseudomonas aeruginosa isolates by genetic methods. Marumo, K., Takeda, A., Nakamura, Y., Nakaya, K. J. Antimicrob. Chemother. (1999) [Pubmed]
  6. Comparative in-vitro activities of newer cephalosporins cefclidin, cefepime, and cefpirome against ceftazidime- or imipenem-resistant Pseudomonas aeruginosa. Watanabe, N., Hiruma, R., Katsu, K. J. Antimicrob. Chemother. (1992) [Pubmed]
  7. Role of the aminothiadiazolyl group in the antipseudomonal activity of cefclidin. Watanabe, N., Sugiyama, I. J. Antibiot. (1992) [Pubmed]
  8. Bacterial biofilm in chronic airway infection. Ohgaki, N. Kansenshogaku Zasshi (1994) [Pubmed]
  9. Pharmacological effects of cefclidin on the central nervous system. Kaneko, T., Katsu, K., Fujimoto, M., Yamauchi, H., Algate, D.R., Beard, D.J., Jobling, C.M., Munt, P.L. The Japanese journal of antibiotics. (1993) [Pubmed]
  10. Cefclidin (E1040), a novel cephalosporin: lack of selection of beta-lactamase overproducing mutants in an in vitro pharmacokinetic model system. Watanabe, N.A., Katsu, K. J. Antibiot. (1992) [Pubmed]
 
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