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Chemical Compound Review

LS-29     1,2,3-trichloropropane

Synonyms: CHEMBL346933, CCRIS 5874, NCI-C60220, AG-H-94985, ACMC-209s6o, ...
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Disease relevance of Glyceryl trichlorohydrin


High impact information on Glyceryl trichlorohydrin


Biological context of Glyceryl trichlorohydrin


Anatomical context of Glyceryl trichlorohydrin


Gene context of Glyceryl trichlorohydrin

  • In the intact nuclei, trichloropropane oxide, a potent inhibitor of epoxide hydratase, caused no significant increment in AFB1 binding to DNA [12].

Analytical, diagnostic and therapeutic context of Glyceryl trichlorohydrin


  1. Results of a 90-day toxicity study on 1,2,3- and 1,1,2-trichloropropane administered via the drinking water. Villeneuve, D.C., Chu, I., Secours, V.E., Coté, M.G., Plaa, G.L., Valli, V.E. Sci. Total Environ. (1985) [Pubmed]
  2. Evaluation of the subchronic and reproductive effects of a series of chlorinated propanes in the rat. I. Toxicity of 1,2,3-trichloropropane. Johannsen, F.R., Levinskas, G.J., Rusch, G.M., Terrill, J.B., Schroeder, R.E. Journal of toxicology and environmental health. (1988) [Pubmed]
  3. Biodegradation of 1,2,3-trichloropropane through directed evolution and heterologous expression of a haloalkane dehalogenase gene. Bosma, T., Damborský, J., Stucki, G., Janssen, D.B. Appl. Environ. Microbiol. (2002) [Pubmed]
  4. The utility of the guppy (Poecilia reticulata) and medaka (Oryzias latipes) in evaluation of chemicals for carcinogenicity. Kissling, G.E., Bernheim, N.J., Hawkins, W.E., Wolfe, M.J., Jokinen, M.P., Smith, C.S., Herbert, R.A., Boorman, G.A. Toxicol. Sci. (2006) [Pubmed]
  5. The effects of exposure route on DNA adduct formation and cellular proliferation by 1,2,3-trichloropropane. La, D.K., Schoonhoven, R., Ito, N., Swenberg, J.A. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
  6. In vitro mutagenicity and genotoxicity study of 1,2-dichloroethylene, 1,1,2-trichloroethane, 1,3-dichloropropane, 1,2,3-trichloropropane and 1,1,3-trichloropropene, using the micronucleus test and the alkaline single cell gel electrophoresis technique (comet assay) in human lymphocytes. Tafazoli, M., Kirsch-Volders, M. Mutat. Res. (1996) [Pubmed]
  7. In vitro metabolism and bioactivation of 1,2,3-trichloropropane. Weber, G.L., Sipes, I.G. Toxicol. Appl. Pharmacol. (1992) [Pubmed]
  8. Covalent interactions of 1,2,3-trichloropropane with hepatic macromolecules: studies in the male F-344 rat. Weber, G.L., Sipes, I.G. Toxicol. Appl. Pharmacol. (1990) [Pubmed]
  9. Disposition of 1,2,3-trichloropropane in the Fischer 344 rat: conventional and physiological pharmacokinetics. Volp, R.F., Sipes, I.G., Falcoz, C., Carter, D.E., Gross, J.F. Toxicol. Appl. Pharmacol. (1984) [Pubmed]
  10. Rat hepatic DNA damage induced by 1,2,3-trichloropropane. Weber, G.L., Sipes, I.G. Adv. Exp. Med. Biol. (1991) [Pubmed]
  11. 1,2,3-Trichloropropane: a multisite carcinogen in rats and mice. Irwin, R.D., Haseman, J.K., Eustis, S.L. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1995) [Pubmed]
  12. Nuclear envelope-dependent binding of aflatoxin B1 to DNA. Yoshizawa, H., Uchimaru, R., Ito, T., Tashiro, F., Ueno, Y. J. Environ. Pathol. Toxicol. Oncol. (1990) [Pubmed]
  13. NTP carcinogenesis studies of 2,2-bis(bromomethyl)-1,3-propanediol, nitromethane, and 1,2,3-trichloropropane (cas nos. 3296-90-0, 75-52-5, and 96-18-4) in guppies (Poecilia reticulata) and medaka (Oryzias latipes) (Waterborne Studies). Gunnels, S.R., Carver, P.H., Harper, L.M., Rathman, E.S., Serbus, D.C. National Toxicology Program technical report series. (2005) [Pubmed]
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