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Chemical Compound Review

Eperezolid     N-[[(5S)-3-[3-fluoro-4-[4- (2...

Synonyms: CHEMBL47955, SureCN186562, LS-9620, AC1L2JGQ, AC1Q5LET, ...
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Disease relevance of U-100592


High impact information on U-100592


Chemical compound and disease context of U-100592


Biological context of U-100592


Anatomical context of U-100592


Associations of U-100592 with other chemical compounds


Gene context of U-100592


Analytical, diagnostic and therapeutic context of U-100592


  1. Ribosomes from an oxazolidinone-resistant mutant confer resistance to eperezolid in a Staphylococcus aureus cell-free transcription-translation assay. Murray, R.W., Schaadt, R.D., Zurenko, G.E., Marotti, K.R. Antimicrob. Agents Chemother. (1998) [Pubmed]
  2. The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin. Lin, A.H., Murray, R.W., Vidmar, T.J., Marotti, K.R. Antimicrob. Agents Chemother. (1997) [Pubmed]
  3. Activities of the oxazolidinones linezolid and eperezolid in experimental intra-abdominal abscess due to Enterococcus faecalis or vancomycin-resistant Enterococcus faecium. Schülin, T., Thauvin-Eliopoulos, C., Moellering, R.C., Eliopoulos, G.M. Antimicrob. Agents Chemother. (1999) [Pubmed]
  4. MICs of oxazolidinones for Rhodococcus equi strains isolated from humans and animals. Bowersock, T.L., Salmon, S.A., Portis, E.S., Prescott, J.F., Robison, D.A., Ford, C.W., Watts, J.L. Antimicrob. Agents Chemother. (2000) [Pubmed]
  5. In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections. Ford, C.W., Hamel, J.C., Wilson, D.M., Moerman, J.K., Stapert, D., Yancey, R.J., Hutchinson, D.K., Barbachyn, M.R., Brickner, S.J. Antimicrob. Agents Chemother. (1996) [Pubmed]
  6. 1H nuclear magnetic resonance study of oxazolidinone binding to bacterial ribosomes. Zhou, C.C., Swaney, S.M., Shinabarger, D.L., Stockman, B.J. Antimicrob. Agents Chemother. (2002) [Pubmed]
  7. Piperazinyl oxazolidinone antibacterial agents containing a pyridine, diazene, or triazene heteroaromatic ring. Tucker, J.A., Allwine, D.A., Grega, K.C., Barbachyn, M.R., Klock, J.L., Adamski, J.L., Brickner, S.J., Hutchinson, D.K., Ford, C.W., Zurenko, G.E., Conradi, R.A., Burton, P.S., Jensen, R.M. J. Med. Chem. (1998) [Pubmed]
  8. In vitro activities of an investigational quinolone, glycylcycline, glycopeptide, streptogramin, and oxazolidinone tested alone and in combinations against vancomycin-resistant Enterococcus faecium. Mercier, R.C., Penzak, S.R., Rybak, M.J. Antimicrob. Agents Chemother. (1997) [Pubmed]
  9. Mechanism of action of oxazolidinones: effects of linezolid and eperezolid on translation reactions. Shinabarger, D.L., Marotti, K.R., Murray, R.W., Lin, A.H., Melchior, E.P., Swaney, S.M., Dunyak, D.S., Demyan, W.F., Buysse, J.M. Antimicrob. Agents Chemother. (1997) [Pubmed]
  10. In vitro antimicrobial activities and spectra of U-100592 and U-100766, two novel fluorinated oxazolidinones. Jones, R.N., Johnson, D.M., Erwin, M.E. Antimicrob. Agents Chemother. (1996) [Pubmed]
  11. Hypersegmented megakaryocytes and megakaryocytes with multiple separate nuclei in dogs treated with PNU-100592, an oxazolidinone antibiotic. Lund, J.E., Brown, P.K. Toxicologic pathology. (1997) [Pubmed]
  12. In vitro activities of oxazolidinones U-100592 and U-100766 against penicillin-resistant and cephalosporin-resistant strains of Streptococcus pneumoniae. Mason, E.O., Lamberth, L.B., Kaplan, S.L. Antimicrob. Agents Chemother. (1996) [Pubmed]
  13. In vitro activities in new oxazolidinone antimicrobial agents against enterococci. Eliopoulos, G.M., Wennersten, C.B., Gold, H.S., Moellering, R.C. Antimicrob. Agents Chemother. (1996) [Pubmed]
  14. Serum inhibitory titers and serum bactericidal titers for human subjects receiving multiple doses of the antibacterial oxazolidinones eperezolid and linezolid. Schaadt, R.D., Batts, D.H., Daley-Yates, P.T., Pawsey, S.D., Stalker, D.J., Zurenko, G.E. Diagn. Microbiol. Infect. Dis. (1997) [Pubmed]
  15. In vitroActivity of Linezolid and Eperezolid, Two Novel Oxazolidinone Antimicrobial Agents, Against Anaerobic Bacteria. Yagi, B.H., Zurenko, G.E. Anaerobe (1997) [Pubmed]
  16. Simple method for the assay of eperezolid in brain heart infusion broth by high-performance liquid chromatography. Li, J., Rayner, C.R., Nation, R.L. Journal of pharmaceutical and biomedical analysis. (2004) [Pubmed]
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