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AOC3  -  amine oxidase, copper containing 3...

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Disease relevance of AOC3


Psychiatry related information on AOC3


High impact information on AOC3


Chemical compound and disease context of AOC3


Biological context of AOC3


Anatomical context of AOC3

  • Time-dependent activation of the semicarbazide-sensitive amine oxidase (SSAO) from ox lung microsomes [16].
  • These results definitively confirm the presence of SSAO in human and bovine cerebrovascular tissues and they demonstrate for the first time, the presence of this amine oxidase in endothelial cells from microvessels, through biochemical and immunological approaches [17].
  • The IC50 values were estimated to be 2 x 10(-9) M, 5 x 10(-9) M, 8 x 10(-8) M and 2 x 10(-8) M for SSAO from dog aorta, rat aorta, bovine aorta and human umbilical artery, respectively [15].
  • We have investigated the presence of SSAO in human and bovine brain microvessels by biochemical and immunohistological techniques, and we have compared it with SSAO present in meninges from the same species [17].
  • SSAO activity towards dopamine was present in the choroid and the retina, but not in the iris or the optic nerve [18].

Associations of AOC3 with chemical compounds


Regulatory relationships of AOC3

  • Cytotoxicity caused by bovine serum amine oxidase (5.7 x 10(-3) U/mL) and spermine (340 microM) was completely inhibited by catalase only during short incubation times after which time cytotoxicity occurred [21].

Other interactions of AOC3


Analytical, diagnostic and therapeutic context of AOC3


  1. Anti-tumoral effect of native and immobilized bovine serum amine oxidase in a mouse melanoma model. Averill-Bates, D.A., Chérif, A., Agostinelli, E., Tanel, A., Fortier, G. Biochem. Pharmacol. (2005) [Pubmed]
  2. Heat enhancement of cytotoxicity induced by oxidation products of spermine in Chinese hamster ovary cells. Agostinelli, E., Przybytkowski, E., Mondovi, B., Averill-Bates, D.A. Biochem. Pharmacol. (1994) [Pubmed]
  3. Contribution of serum and cellular semicarbazide-sensitive amine oxidase to amine metabolism and cardiovascular toxicity. Conklin, D.J., Langford, S.D., Boor, P.J. Toxicol. Sci. (1998) [Pubmed]
  4. Modulation of K+ channel currents by serum amineoxidase in neurons. Wu, L., Mateescu, M.A., Wang, X.T., Mondovi, B., Wang, R. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  5. Overexpression of semicarbazide sensitive amine oxidase in the cerebral blood vessels in patients with Alzheimer's disease and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Ferrer, I., Lizcano, J.M., Hernández, M., Unzeta, M. Neurosci. Lett. (2002) [Pubmed]
  6. A new redox cofactor in eukaryotic enzymes: 6-hydroxydopa at the active site of bovine serum amine oxidase. Janes, S.M., Mu, D., Wemmer, D., Smith, A.J., Kaur, S., Maltby, D., Burlingame, A.L., Klinman, J.P. Science (1990) [Pubmed]
  7. Primary structures for a mammalian cellular and serum copper amine oxidase. Mu, D., Medzihradszky, K.F., Adams, G.W., Mayer, P., Hines, W.M., Burlingame, A.L., Smith, A.J., Cai, D., Klinman, J.P. J. Biol. Chem. (1994) [Pubmed]
  8. Kinetics and stereospecificity of the lysyl oxidase reaction. Shah, M.A., Scaman, C.H., Palcic, M.M., Kagan, H.M. J. Biol. Chem. (1993) [Pubmed]
  9. Tyrosine codon corresponds to topa quinone at the active site of copper amine oxidases. Mu, D., Janes, S.M., Smith, A.J., Brown, D.E., Dooley, D.M., Klinman, J.P. J. Biol. Chem. (1992) [Pubmed]
  10. Specific detection of quinoproteins by redox-cycling staining. Paz, M.A., Flückiger, R., Boak, A., Kagan, H.M., Gallop, P.M. J. Biol. Chem. (1991) [Pubmed]
  11. Allylamine-induced vascular toxicity in vitro: prevention by semicarbazide-sensitive amine oxidase inhibitors. Ramos, K., Grossman, S.L., Cox, L.R. Toxicol. Appl. Pharmacol. (1988) [Pubmed]
  12. Structure and tissue-specific expression of genes encoding bovine copper amine oxidases. Høgdall, E.V., Houen, G., Borre, M., Bundgaard, J.R., Larsson, L.I., Vuust, J. Eur. J. Biochem. (1998) [Pubmed]
  13. Electrostatic control of oxidative deamination catalysed by bovine serum amine oxidase. Stevanato, R., Mondovi, B., Befani, O., Scarpa, M., Rigo, A. Biochem. J. (1994) [Pubmed]
  14. Identification of the quinone cofactor in mammalian semicarbazide-sensitive amine oxidase. Holt, A., Alton, G., Scaman, C.H., Loppnow, G.R., Szpacenko, A., Svendsen, I., Palcic, M.M. Biochemistry (1998) [Pubmed]
  15. Inhibition of a type B monoamine oxidase inhibitor, (E)-2-(4-fluorophenethyl)-3-fluoroallylamine (MDL-72974A), on semicarbazide-sensitive amine oxidases isolated from vascular tissues and sera of different species. Yu, P.H., Zuo, D.M. Biochem. Pharmacol. (1992) [Pubmed]
  16. Time-dependent activation of the semicarbazide-sensitive amine oxidase (SSAO) from ox lung microsomes. Lizcano, J.M., Tipton, K.F., Unzeta, M. Biochem. J. (2000) [Pubmed]
  17. Semicarbazide-sensitive amine oxidase (SSAO) from human and bovine cerebrovascular tissues: biochemical and immunohistological characterization. Castillo, V., Lizcano, J.M., Visa, J., Unzeta, M. Neurochem. Int. (1998) [Pubmed]
  18. Contribution of different amine oxidases to the metabolism of dopamine in bovine retina. Fernández de Arriba, A., Lizcano, J.M., Balsa, D., Unzeta, M. Biochem. Pharmacol. (1991) [Pubmed]
  19. Spectroscopic detection of chemical intermediates in the reaction of para-substituted benzylamines with bovine serum amine oxidase. Hartmann, C., Brzovic, P., Klinman, J.P. Biochemistry (1993) [Pubmed]
  20. Stereochemical course of tyramine oxidation by semicarbazide-sensitive amine oxidase. Scaman, C.H., Palcic, M.M. Biochemistry (1992) [Pubmed]
  21. Aldehyde dehydrogenase and cytotoxicity of purified bovine serum amine oxidase and spermine in Chinese hamster ovary cells. Averill-Bates, D.A., Agostinelli, E., Przybytkowski, E., Mondovi, B. Biochem. Cell Biol. (1994) [Pubmed]
  22. Interaction of bovine serum amine oxidase with the polyamine oxidase inactivator MDL 72527. Agostinelli, E., Palmigiani, P., Vedova, L.D., Tempera, G., Belli, F., Seiler, N. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  23. Amine oxidase, spermine, and hyperthermia induce cytotoxicity in P-glycoprotein overexpressing multidrug resistant Chinese hamster ovary cells. Lord-Fontaine, S., Agostinelli, E., Przybytkowski, E., Averill-Bates, D.A. Biochem. Cell Biol. (2001) [Pubmed]
  24. Domains in bovine serum amine oxidase. Giartosio, A., Agostinelli, E., Mondovi, B. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  25. Serum amine oxidase can specifically recognize and oxidize aminohexyl (AH) chains on AH-Sepharose support: single-step affinity immobilization. Befani, O., Graziani, M.T., Agostinelli, E., Grippa, E., Mondovì, B., Mateescu, M.A. Biotechnol. Appl. Biochem. (1998) [Pubmed]
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