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Chemical Compound Review

Nardil     phenethylhydrazine

Synonyms: Fenelzina, Fenelzyna, Fenelzyne, Stinerval, Phenalzine, ...
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Disease relevance of phenethylhydrazine


Psychiatry related information on phenethylhydrazine

  • Atypical depression, panic attacks, and response to imipramine and phenelzine. A replication [6].
  • The results show that drugs such as phenelzine are effective in nonendogenous depression and phobic disorders [5].
  • These results only partially support previous positive reports of phenelzine treatment of PTSD [7].
  • RESULTS: With the use of an intention-to-treat strategy, the response rates (21-item Hamilton Rating Scale for Depression score, < or =9) were significantly greater after cognitive therapy (58%) and phenelzine (58%) than after pill placebo (28%) [8].
  • METHODS: One hundred thirty-three patients from 2 sites received 12 weeks of CBGT, phenelzine therapy, pill placebo administration, or educational-supportive group therapy (an attention-placebo treatment of equal credibility to CBGT) [9].

High impact information on phenethylhydrazine


Chemical compound and disease context of phenethylhydrazine


Biological context of phenethylhydrazine


Anatomical context of phenethylhydrazine


Associations of phenethylhydrazine with other chemical compounds


Gene context of phenethylhydrazine


Analytical, diagnostic and therapeutic context of phenethylhydrazine


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  2. Priapism related to phenelzine therapy. Yeragani, V.K., Gershon, S. N. Engl. J. Med. (1987) [Pubmed]
  3. Crohn's disease remission with phenelzine treatment. Kast, R.E. Gastroenterology (1998) [Pubmed]
  4. Treatment of bulimia with phenelzine. A double-blind, placebo-controlled study. Walsh, B.T., Stewart, J.W., Roose, S.P., Gladis, M., Glassman, A.H. Arch. Gen. Psychiatry (1984) [Pubmed]
  5. Clinical pharmacology of phenelzine. Robinson, D.S., Nies, A., Ravaris, C.L., Ives, J.O., Bartlett, D. Arch. Gen. Psychiatry (1978) [Pubmed]
  6. Atypical depression, panic attacks, and response to imipramine and phenelzine. A replication. Quitkin, F.M., McGrath, P.J., Stewart, J.W., Harrison, W., Tricamo, E., Wager, S.G., Ocepek-Welikson, K., Nunes, E., Rabkin, J.G., Klein, D.F. Arch. Gen. Psychiatry (1990) [Pubmed]
  7. Posttraumatic stress disorder in Israeli combat veterans. Effect of phenelzine treatment. Lerer, B., Bleich, A., Kotler, M., Garb, R., Hertzberg, M., Levin, B. Arch. Gen. Psychiatry (1987) [Pubmed]
  8. Treatment of atypical depression with cognitive therapy or phenelzine: a double-blind, placebo-controlled trial. Jarrett, R.B., Schaffer, M., McIntire, D., Witt-Browder, A., Kraft, D., Risser, R.C. Arch. Gen. Psychiatry (1999) [Pubmed]
  9. Cognitive behavioral group therapy vs phenelzine therapy for social phobia: 12-week outcome. Heimberg, R.G., Liebowitz, M.R., Hope, D.A., Schneier, F.R., Holt, C.S., Welkowitz, L.A., Juster, H.R., Campeas, R., Bruch, M.A., Cloitre, M., Fallon, B., Klein, D.F. Arch. Gen. Psychiatry (1998) [Pubmed]
  10. Phenelzine in the treatment of aphthous ulcers of the mouth. Lejonc, J.L., Fourestie, V. N. Engl. J. Med. (1985) [Pubmed]
  11. Sleep and sleep electroencephalogram in depressed patients treated with phenelzine. Landolt, H.P., Raimo, E.B., Schnierow, B.J., Kelsoe, J.R., Rapaport, M.H., Gillin, J.C. Arch. Gen. Psychiatry (2001) [Pubmed]
  12. Treatment of atypical depression with cognitive therapy or phenelzine. Levitan, R.D. Arch. Gen. Psychiatry (2000) [Pubmed]
  13. Efficacy of phenelzine and haloperidol in borderline personality disorder. Soloff, P.H., Cornelius, J., George, A., Nathan, S., Perel, J.M., Ulrich, R.F. Arch. Gen. Psychiatry (1993) [Pubmed]
  14. Quadriplegia, orthostatic hypotension, and phenelzine with tyramine. Wood, C.A., Riddle, J., Reed, R., Paul, C. Ann. Intern. Med. (1985) [Pubmed]
  15. Fluoxetine versus phenelzine in obsessive-compulsive disorder. Golwyn, D.H., Sevlie, C.P. The American journal of psychiatry. (1999) [Pubmed]
  16. Case report of a toxic reaction from a combination of tryptophan and phenelzine. Thomas, J.M., Rubin, E.H. The American journal of psychiatry. (1984) [Pubmed]
  17. Pyridoxine deficiency and peripheral neuropathy associated with long-term phenelzine therapy. Heller, C.A., Friedman, P.A. Am. J. Med. (1983) [Pubmed]
  18. Acetylation phenotype, platelet monoamine oxidase inhibition, and the effectiveness of phenelzine in depression. Davidson, J., McLeod, M.N., Blum, M.R. The American journal of psychiatry. (1978) [Pubmed]
  19. Spontaneous remission of MAOI-induced anorgasmia. Nurnberg, H.G., Levine, P.E. The American journal of psychiatry. (1987) [Pubmed]
  20. Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. Benmansour, S., Cecchi, M., Morilak, D.A., Gerhardt, G.A., Javors, M.A., Gould, G.G., Frazer, A. J. Neurosci. (1999) [Pubmed]
  21. Platelet MAO inhibition, urinary MHPG, and leukocyte beta-adrenergic receptors in depressed patients treated with phenelzine. Sharma, R.P., Janicak, P.G., Javaid, J.I., Pandey, G.N., Gierl, B., Davis, J.M. The American journal of psychiatry. (1990) [Pubmed]
  22. Effect of phenelzine on thyroid function in depressed patients. Joffe, R.T., Singer, W. Biol. Psychiatry (1987) [Pubmed]
  23. Free radical pathways in the in vitro hepatic metabolism of phenelzine. Ortiz de Montellano, P.R., Watanabe, M.D. Mol. Pharmacol. (1987) [Pubmed]
  24. Chronic treatment with the monoamine oxidase inhibitor phenelzine increases hypothalamic-pituitary-adrenocortical activity in male C57BL/6 mice: relevance to atypical depression. Kier, A., Han, J., Jacobson, L. Endocrinology (2005) [Pubmed]
  25. Relevance of DMS-III depressive subtype and chronicity of antidepressant efficacy in atypical depression. Differential response to phenelzine, imipramine, and placebo. Stewart, J.W., McGrath, P.J., Quitkin, F.M., Harrison, W., Markowitz, J., Wager, S., Leibowitz, M.R. Arch. Gen. Psychiatry (1989) [Pubmed]
  26. Effects of antidepressant treatment on inhibitory avoidance behavior and amygdaloid beta-adrenoceptors in rats. Daws, L.C., Lopez, R., Frazer, A. Neuropsychopharmacology (1998) [Pubmed]
  27. Adverse reactions to monoamine oxidase inhibitors. Part I. A comparative study. Rabkin, J., Quitkin, F., Harrison, W., Tricamo, E., McGrath, P. Journal of clinical psychopharmacology. (1984) [Pubmed]
  28. Mechanism-based inactivation of human cytochrome P4502C8 by drugs in vitro. Polasek, T.M., Elliot, D.J., Lewis, B.C., Miners, J.O. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  29. The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications. Brady, L.S., Gold, P.W., Herkenham, M., Lynn, A.B., Whitfield, H.J. Brain Res. (1992) [Pubmed]
  30. Monoamine oxidase-inhibiting properties of SR 95191, a new pyridazine derivative, in the rat: evidence for selective and reversible inhibition of monoamine oxidase type A in vivo but not in vitro. Kan, J.P., Steinberg, R., Leclercq, J., Worms, P., Biziere, K. J. Neurochem. (1988) [Pubmed]
  31. Inhibition of monoamine oxidase by two substrate-analogues, with different preferences for 5-hydroxytryptamine neurons. Kim, S.K., Toyoshima, Y., Arai, Y., Kinemuchi, H., Tadano, T., Oyama, K., Satoh, N., Kisara, K. Neuropharmacology (1991) [Pubmed]
  32. Effect of nonselective and selective inhibitors of monoamine oxidases A and B on pethidine toxicity in mice. Boden, R., Botting, R., Coulson, P., Spanswick, G. Br. J. Pharmacol. (1984) [Pubmed]
  33. Response to phenelzine and imipramine in placebo nonresponders with atypical depression. A new application of the crossover design. Quitkin, F.M., Harrison, W., Stewart, J.W., McGrath, P.J., Tricamo, E., Ocepek-Welikson, K., Rabkin, J.G., Wager, S.G., Nunes, E., Klein, D.F. Arch. Gen. Psychiatry (1991) [Pubmed]
  34. Response to phenelzine among depressed patients with features of hysteroid dysphoria. Kayser, A., Robinson, D.S., Nies, A., Howard, D. The American journal of psychiatry. (1985) [Pubmed]
  35. Continuation pharmacotherapy of borderline personality disorder with haloperidol and phenelzine. Cornelius, J.R., Soloff, P.H., Perel, J.M., Ulrich, R.F. The American journal of psychiatry. (1993) [Pubmed]
  36. DNA strand scission by the carbon radical derived from 2-phenyl-ethylhydrazine metabolism. Augusto, O., Faljoni-Alário, A., Leite, L.C., Nóbrega, F.G. Carcinogenesis (1984) [Pubmed]
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