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Chemical Compound Review

CHEMBL2074837     tetrahexylazanium

Synonyms: ZINC03880972, AR-1K0850, AC1L2NY2, AC1Q2VP3, Tetrahexylammonium, ...
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High impact information on tetrahexylammonium

  • Quantitation of D-glucaro-1,4-lactone and total D-glucaric acid as the sum of D-glucaric acid and its lactones in the bile and urine involved extraction of bile with tetrahexylammonium chloride, adjustment of pH, boiling and determination of percentage inhibition of beta-glucuronidase activity [1].
  • The K(m)-V(j) relationships for TPeA(+) and THxA(+) were fit with different reaction rate models for a symmetrical (homotypic) connexin gap junction channel and were described by either a one- or two-site model that assumed each ion traversed the entire V(j) field [2].
  • 4. The K+ channel-blocking quaternary ammonium ions, tetrabutylammonium (TBuA), tetrapentylammonium (TPeA) and tetrahexylammonium (THeA), but not the Na+ channel blocker tetrodotoxin (TTX), reduced proliferation in a dose-dependent fashion offering further evidence for a role for K+ channels in Schwann cell proliferation [3].
  • The data suggest that, as K(+) channel blockers and apoptosis antagonists, TPeA and THA are much more potent than TEA; however, they have nonspecific actions on several voltage-gated or ligand-gated channels [4].
  • TPeA and THA (0.1-1.0 microM) attenuated staurosporine-induced caspase-3 activation and neuronal apoptosis [4].

Biological context of tetrahexylammonium


Anatomical context of tetrahexylammonium


Associations of tetrahexylammonium with other chemical compounds


Analytical, diagnostic and therapeutic context of tetrahexylammonium

  • A method for derivatization of (S)-3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) by phenacylation in tetrahexylammonium hydrogensulphate as phase-transfer reagent and high-performance liquid chromatography of the HMG-diphenacyl ester is described [10].


  1. D-glucaro-1,4-lactone: its excretion in the bile and urine and effect on the biliary secretion of beta-glucuronidase after oral administration in rats. Macfadyen, A., Ho, K.J. Hepatology (1989) [Pubmed]
  2. Ionic blockade of the rat connexin40 gap junction channel by large tetraalkylammonium ions. Musa, H., Gough, J.D., Lees, W.J., Veenstra, R.D. Biophys. J. (2001) [Pubmed]
  3. Mitogenic factors regulate ion channels in Schwann cells cultured from newborn rat sciatic nerve. Wilson, G.F., Chiu, S.Y. J. Physiol. (Lond.) (1993) [Pubmed]
  4. Effects of tetraethylammonium analogs on apoptosis and membrane currents in cultured cortical neurons. Wang, X., Xiao, A.Y., Ichinose, T., Yu, S.P. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  5. Determination of hippuric acid and o-, m- and p-methylhippuric acids in urine by capillary gas chromatography. Kataoka, H., Manabe, K., Nakase, S., Makita, M. Journal of pharmaceutical and biomedical analysis. (1991) [Pubmed]
  6. Tetrahexylammonium ions increase Ca2+ sensitivity of contraction of guinea-pig ileal smooth muscle. Uyama, Y., Muraki, K., Walsh, M.P., Imaizumi, Y., Watanabe, M. Pflugers Arch. (1994) [Pubmed]
  7. Human beta-glucuronidase. Measurement of its activity in gallbladder bile devoid of intrinsic interference. Ho, Y.C., Ho, K.J. Dig. Dis. Sci. (1988) [Pubmed]
  8. Subtype identification and functional properties of inositol 1,4, 5-trisphosphate receptors in heart and aorta. Tovey, S.C., Dyer, J.L., Godfrey, R.E., Khan, S.Z., Bilmen, J.G., Mezna, M., Michelangeli, F. Pharmacol. Res. (2000) [Pubmed]
  9. Determination of phosphonoformate (foscarnet) in calf and human serum by automated solid-phase extraction and high-performance liquid chromatography with amperometric detection. Ba, B.B., Corniot, A.G., Ducint, D., Breilh, D., Grellet, J., Saux, M.C. J. Chromatogr. B Biomed. Sci. Appl. (1999) [Pubmed]
  10. High-performance liquid chromatographic determination of 3-hydroxy-3-methylglutaryl coenzyme A as diphenacyl ester of 3-hydroxy-3-methylglutarate. Heintze, A., Schultz, G. J. Chromatogr. B, Biomed. Appl. (1994) [Pubmed]
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