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Chemical Compound Review

AG-E-08950     tetrapentylazanium

Synonyms: CHEMBL2074704, CHEBI:35009, CTK4D0134, ZINC03861692, AC1L29MN, ...
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High impact information on tetraamylammonium

  • Because 4AP block was inhibited by tetrapentylammonium, we conclude that determinants of 4AP binding lie in the S6 segment that forms the cytoplasmic vestibule of the pore and that this site may overlap a quaternary ammonium site [1].
  • Unexpectedly, we found that blockade of plasma membrane K+ channels by tetrapentylammonium (TPA), which leads to a DeltaP sip collapse, can prevent the thymocyte apoptosis induced by exposure to the glucocorticoid receptor agonist dexamethasone, the topoisomerase inhibitor etoposide, gamma-irradiation, or ceramide [2].
  • The effects of internal tetrabutylammonium (TBA) and tetrapentylammonium (TPeA) were studied on human cardiac sodium channels (hH1) expressed in a mammalian tsA201 cell line [3].
  • Tetrapentylammonium produced a stronger block than TEA at the internal site, and the block was relieved by inward K+ currents, therefore suggesting that the internal TEA binding site is located within the K+ conduction pathway [4].
  • After pretreatment of urine samples with a Sep-Pak C18 cartridge, four 17OS sulfates and seven 17OS glucuronides in the pretreated urine samples were reacted with tetrapentylammonium ions to form ion pairs [5].

Biological context of tetraamylammonium


Anatomical context of tetraamylammonium


Associations of tetraamylammonium with other chemical compounds


  1. Segmental exchanges define 4-aminopyridine binding and the inner mouth of K+ pores. Kirsch, G.E., Shieh, C.C., Drewe, J.A., Vener, D.F., Brown, A.M. Neuron (1993) [Pubmed]
  2. Plasma membrane potential in thymocyte apoptosis. Dallaporta, B., Marchetti, P., de Pablo, M.A., Maisse, C., Duc, H.T., Métivier, D., Zamzami, N., Geuskens, M., Kroemer, G. J. Immunol. (1999) [Pubmed]
  3. Evidence for a direct interaction between internal tetra-alkylammonium cations and the inactivation gate of cardiac sodium channels. O'Leary, M.E., Kallen, R.G., Horn, R. J. Gen. Physiol. (1994) [Pubmed]
  4. Patterns of internal and external tetraethylammonium block in four homologous K+ channels. Taglialatela, M., Vandongen, A.M., Drewe, J.A., Joho, R.H., Brown, A.M., Kirsch, G.E. Mol. Pharmacol. (1991) [Pubmed]
  5. Direct determination of four sulfates and seven glucuronides of 17-oxosteroids in urine by fluorescence "high-performance" liquid chromatography. Iwata, J., Suga, T. Clin. Chem. (1989) [Pubmed]
  6. Thin-layer potentiometric analysis of lipid antigen-antibody reaction by tetrapentylammonium (TPA+) ion loaded liposomes and TPA+ ion selective electrode. Shiba, K., Umezawa, Y., Watanabe, T., Ogawa, S., Fujiwara, S. Anal. Chem. (1980) [Pubmed]
  7. Characterization of regulatory mechanisms and states of human organic cation transporter 2. Biermann, J., Lang, D., Gorboulev, V., Koepsell, H., Sindic, A., Schröter, R., Zvirbliene, A., Pavenstädt, H., Schlatter, E., Ciarimboli, G. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  8. Electron-capture gas chromatography of plasma sulphonylureas after extractive methylation. Hartvig, P., Fagerlund, C., Gyllenhaal, O. J. Chromatogr. (1980) [Pubmed]
  9. Voltage-gated K(+) channels are associated with cell proliferation and cell cycle of ovarian cancer cell. Zhanping, W., Xiaoyu, P., Na, C., Shenglan, W., Bo, W. Gynecol. Oncol. (2007) [Pubmed]
  10. Extractive alkylation of sulphonamide diuretics and their determination by electron-capture gas chromatography. Fagerlund, C., Hartvig, P., Lindström, B. J. Chromatogr. (1979) [Pubmed]
  11. Functional characterization of choroid plexus epithelial cells in primary culture. Villalobos, A.R., Parmelee, J.T., Pritchard, J.B. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  12. Beta-adrenoceptor-mediated relaxation inhibited by tetrapentylammonium ions in rat mesenteric artery. Huang, Y., Kwok, K.H. Life Sci. (1998) [Pubmed]
  13. Unique effect of tetrapentylammonium ions on sympathetic transmission in rat vas deferens. Huang, Y., Lau, C.W. Journal of autonomic pharmacology. (1998) [Pubmed]
  14. Inhibition of slow-wave repolarization and Ca(2+)-activated K+ channels by quaternary ammonium ions. Carl, A., Frey, B.W., Ward, S.M., Sanders, K.M., Kenyon, J.L. Am. J. Physiol. (1993) [Pubmed]
  15. Arteriolar tone is determined by activity of ATP-sensitive potassium channels. Jackson, W.F. Am. J. Physiol. (1993) [Pubmed]
  16. Contractile and relaxant effects of tetrapentylammonium ions in rat isolated mesenteric artery. Kwok, K.H., Chan, N.W., Lau, C.W., Huang, Y. Pharmacology (1998) [Pubmed]
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