High impact information on tetraamylammonium

• Because 4AP block was inhibited by tetrapentylammonium, we conclude that determinants of 4AP binding lie in the S6 segment that forms the cytoplasmic vestibule of the pore and that this site may overlap a quaternary ammonium site [1].
• Unexpectedly, we found that blockade of plasma membrane K+ channels by tetrapentylammonium (TPA), which leads to a DeltaP sip collapse, can prevent the thymocyte apoptosis induced by exposure to the glucocorticoid receptor agonist dexamethasone, the topoisomerase inhibitor etoposide, gamma-irradiation, or ceramide [2].
• The effects of internal tetrabutylammonium (TBA) and tetrapentylammonium (TPeA) were studied on human cardiac sodium channels (hH1) expressed in a mammalian tsA201 cell line [3].
• Tetrapentylammonium produced a stronger block than TEA at the internal site, and the block was relieved by inward K+ currents, therefore suggesting that the internal TEA binding site is located within the K+ conduction pathway [4].
• After pretreatment of urine samples with a Sep-Pak C18 cartridge, four 17OS sulfates and seven 17OS glucuronides in the pretreated urine samples were reacted with tetrapentylammonium ions to form ion pairs [5].

Biological context of tetraamylammonium

• Thin-layer potentiometric analysis of lipid antigen-antibody reaction by tetrapentylammonium (TPA+) ion loaded liposomes and TPA+ ion selective electrode [6].
• Inhibition of amiloride and ASP uptake by several organic cations was also measured [IC50 (in microM) for amiloride and ASP, respectively, tetraethylammonium (TEA) 98 and 30, cimetidine 14 and 26, and tetrapentylammonium (TPA) 7 and 2] [7].
• A higher pH or use of tetrapentylammonium as counter-ion caused hydrolysis of the sulphonylureas [8].
• Non-selective K(+) channel blockers tetrapentylammonium (TPeA) and verapamil had similar inhibitory effects on A2780 cell proliferation and cell cycle [9].
• The extractive alkylation of 11 sulphonamide diuretics has been evaluated using tetrabutylammonium, tetrapentylammonium or tetrahexylammonium as counter ion at different pH values and methyl iodide in methylene chloride as the organic phase [10].

Anatomical context of tetraamylammonium

• 14C-Tetraethylammonium (TEA), a prototypic organic cation, was accumulated by isolated choroid plexus in a time-dependent manner; uptake was inhibited by tetrapentylammonium (TePA) [11].
• Beta-adrenoceptor-mediated relaxation inhibited by tetrapentylammonium ions in rat mesenteric artery [12].
• Unique effect of tetrapentylammonium ions on sympathetic transmission in rat vas deferens [13].
• We studied the effects of the K+ channel blocker tetrapentylammonium (TPeA) on the electrical activity of intact circular smooth muscle from canine colon [14].
• Concentration-related constriction of cheek pouch arterioles was also observed with tetrapentylammonium, although this agent appeared to have toxic effects on the microcirculation [15].

Associations of tetraamylammonium with other chemical compounds

• Contractile and relaxant effects of tetrapentylammonium ions in rat isolated mesenteric artery [16].
• 1. Effects of tetrapentylammonium ions (TPA+) on contractile responses induced by electric field stimulation and by exogenous agonist such as noradrenaline, ATP and high K+ were examined in the isolated epididymal half of the rat vas deferens [13].

References