Disease relevance of Perfluorophenanthrene

• Outcomes and complications associated with perfluoro-n-octane and perfluoroperhydrophenanthrene in complex retinal detachment repair [1].
• The management of giant retinal tears using perfluoroperhydrophenanthrene. A multicenter case series. Vitreon Collaborative Study Group [2].
• Use of perfluoroperhydrophenanthrene in the management of suprachoroidal hemorrhages [3].
• Tolerance to perfluoroperhydrophenanthrene and the development of proliferative vitreoretinopathy with its extended use are not clear [4].
• PURPOSE: We studied the toxicity of perfluorophenanthrene (PFP), used as short-, medium-, or long-term internal tamponading substance, on the rabbit choroid and retina [5].

High impact information on Perfluorophenanthrene

• Eyes with 0.025 cc PFD or PFP droplets showed vacuolization of the inferior trabecular meshwork 8 weeks postoperatively that was comparable with eyes which had a 50% aqueous replacement for 4 weeks [6].
• Intraoperative complications of perfluoroperhydrophenanthrene: subretinal perfluorocarbon, retinal slippage and residual perfluorocarbon. Vitreon Study Group [7].
• BACKGROUND AND OBJECTIVE: To detect the effect of Perfluoroperhydrophenanthrene (vitreon) on intraocular pressure (IOP) changes [8].
• BACKGROUND: An earlier analysis of postoperative complications of the perfluorocarbon liquid perfluoroperhydrophenanthrene (Vitreon) showed a low overall rate of posterior segment complications [7].
• CONCLUSION: Residual perfluorophenanthrene in the anterior chamber does not induce gross corneal damage or ocular inflammation, although structural changes indicating the damage of the corneal endothelium, can be shown by specular microscopy at the contact sites [9].

Chemical compound and disease context of Perfluorophenanthrene

• PURPOSE: To evaluate the toxicity and efficacy of 5-fluorouracil (5-FU) in combination with perfluoroperhydrophenanthrene (Vitreon), silicone oil, or a combination of silicone oil and Vitreon in a ratio of 3:2 in the management of experimental proliferative vitreoretinopathy (PVR) [10].

Biological context of Perfluorophenanthrene

• OBJECTIVE: To compare rates of perfluorocarbon liquid (PFCL) intraocular retention, anatomic and visual acuity outcomes, and complications associated with intraoperative perfluoro-n-octane (Perfluoron) versus perfluoroperhydrophenanthrene (Vitreon) in retinal detachment repair [1].

Anatomical context of Perfluorophenanthrene

• Perfluorophenanthrene injected into the anterior chamber of the rabbit eyes had toxic effects on the cornea [11].
• Effects of perfluorophenanthrene on the human corneal endothelium [9].

Analytical, diagnostic and therapeutic context of Perfluorophenanthrene

• We reviewed the records of all patients (nine patients, nine eyes) referred with dislocated lenses who underwent pars plana vitrectomy with perfluorophenanthrene for removal of the lens material at Wills Eye Hospital from July 1, 1991, through Nov. 30, 1991 [12].
• Eight eyes underwent the same surgical procedure without PFPH exchange to serve as a control group [13].
• Ciliary sulcus fixation of a dislocated posterior chamber intraocular lens using liquid perfluorophenanthrene [14].
• The surgical technique included pars plana vitrectomy, endolaser photocoagulation, peripheral cryopexy, scleral buckling, and the use of a liquid perfluorocarbon derivative, perfluorophenanthrene, to achieve and maintain reattachment [15].
• Light and electron microscopy showed minimal or no toxic effects in the 19 eyes, although uptake of perfluorophenanthrene by some preretinal cells was observed 28 days after implantation [11].

References