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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Retinal Perforations

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Disease relevance of Retinal Perforations


High impact information on Retinal Perforations


Chemical compound and disease context of Retinal Perforations


Biological context of Retinal Perforations


Anatomical context of Retinal Perforations


Gene context of Retinal Perforations

  • Vitreous VEGF concentration in the eyes with PDR (1067 +/- 1076 pg/ml) was significantly higher than in eyes with macular holes (34 +/- 5.5 pg/ml) [24].
  • For both macular hole and PDR patients angiopoietin 2 was below the limit of detection [25].
  • RESULTS: Angiopoietin 1 concentrations were low in patients with macular hole (median 17 pg/ml) while in NPDR with CSMO they were 2002 pg/ml (range 289-5820 pg/ml) and in PDR 186 pg/ml (range 26-2292 pg/ml) [25].
  • METHODS: Concentrations of IL-6 and sIL-6R molecules in vitreous fluids were measured in eyes with PVR and idiopathic macular hole (MH), and the localization of IL-6 and IL-6R on the PVR fibrous membrane was studied [26].
  • Vitreous MMP-9 concentration was also significantly higher in eyes with PDR (7.5 +/- 3.8 ng/ml) than in eyes with macular holes (4.2 +/- 1.4 ng/ml) [24].

Analytical, diagnostic and therapeutic context of Retinal Perforations


  1. Iatrogenic intraocular injection of depot corticosteroid and its surgical removal using the pars plana approach. Zinn, K.M. Ophthalmology (1981) [Pubmed]
  2. Comparison of recombinant transforming growth factor-beta-2 and placebo as an adjunctive agent for macular hole surgery. Thompson, J.T., Smiddy, W.E., Williams, G.A., Sjaarda, R.N., Flynn, H.W., Margherio, R.R., Abrams, G.W. Ophthalmology (1998) [Pubmed]
  3. Oral fluorescein angiography with the confocal scanning laser ophthalmoscope. Garcia, C.R., Rivero, M.E., Bartsch, D.U., Ishiko, S., Takamiya, A., Fukui, K., Hirokawa, H., Clark, T., Yoshida, A., Freeman, W.R. Ophthalmology (1999) [Pubmed]
  4. Membranectomy and autologous serum for the retreatment of full-thickness macular holes. Ezra, E., Aylward, W.G., Gregor, Z.J. Arch. Ophthalmol. (1997) [Pubmed]
  5. Miotics and retinal detachment: upgrading the community standard. Kraushar, M.F., Steinberg, J.A. Survey of ophthalmology. (1991) [Pubmed]
  6. In vivo and in vitro feasibility studies of intraocular use of seprafilm to close retinal breaks in bovine and rabbit eyes. Sueda, J., Sakuma, T., Nakamura, H., Usumoto, N., Okuno, T., Arai, M., Hirose, T. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  7. Fluorophore-assisted retinal break detection using antibodies to glial fibrillary acidic protein. Jackson, T.L., Marshall, J. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  8. Clinical evaluation of multifocal electroretinogram. Kondo, M., Miyake, Y., Horiguchi, M., Suzuki, S., Tanikawa, A. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  9. Retinal detachment associated with macular hole in high myopia: using the vitreous anatomy to optimize the surgical approach. Ripandelli, G., Parisi, V., Friberg, T.R., Coppé, A.M., Scassa, C., Stirpe, M. Ophthalmology (2004) [Pubmed]
  10. Glaucoma after macular hole surgery. Chen, C.J. Ophthalmology (1998) [Pubmed]
  11. Retinal pigment epitheliopathy after macular hole surgery. Poliner, L.S., Tornambe, P.E. Ophthalmology (1992) [Pubmed]
  12. The management of giant retinal tears using perfluoroperhydrophenanthrene. A multicenter case series. Vitreon Collaborative Study Group. Kertes, P.J., Wafapoor, H., Peyman, G.A., Calixto, N., Thompson, H. Ophthalmology (1997) [Pubmed]
  13. Silicone oil tamponade to seal macular holes without position restrictions. Goldbaum, M.H., McCuen, B.W., Hanneken, A.M., Burgess, S.K., Chen, H.H. Ophthalmology (1998) [Pubmed]
  14. Management of the fellow eyes of patients with rhegmatogenous retinal detachment. McPherson, A., O'Malley, R., Beltangady, S.S. Ophthalmology (1981) [Pubmed]
  15. Triamcinolone-assisted internal limiting membrane peeling during idiopathic macular hole surgery. Horio, N., Horiguchi, M., Yamamoto, N. Arch. Ophthalmol. (2005) [Pubmed]
  16. Transforming growth factor-beta 2 for the treatment of full-thickness macular holes. A prospective randomized study. Glaser, B.M., Michels, R.G., Kuppermann, B.D., Sjaarda, R.N., Pena, R.A. Ophthalmology (1992) [Pubmed]
  17. Fellow eyes of eyes with macular holes. Bronstein, M.A., Trempe, C.L., Freeman, H.M. Am. J. Ophthalmol. (1981) [Pubmed]
  18. Effectiveness of apraclonidine 1% in preventing intraocular pressure rise following macular hole surgery. Sciscio, A., Casswell, A.G. The British journal of ophthalmology. (2001) [Pubmed]
  19. Phagocytic and digestive activities of retinal pigment epithelium at experimentally produced retinal tears. Moriwaki, M. Osaka city medical journal. (1993) [Pubmed]
  20. Toxicity of intravitreous ceftazidime in primate retina. Campochiaro, P.A., Green, W.R. Arch. Ophthalmol. (1992) [Pubmed]
  21. Multiple components of epiretinal tissues detected by triamcinolone and indocyanine green in macular hole and retinal detachment as a result of high myopia. Sakaguchi, H., Ikuno, Y., Choi, J.S., Ohji, M., Tano, T. Am. J. Ophthalmol. (2004) [Pubmed]
  22. Macular hole in a myopic eye after laser in situ keratomileusis. Ruiz-Moreno, J.M., Artola, A., Pérez-Santonja, J.J., Alió, J.L. Journal of refractive surgery (Thorofare, N.J. : 1995) (2002) [Pubmed]
  23. Ocular perforation in utero. Gobert, A., Vereecken, G., Meire, F., Van Oye, R., De Laey, J.J. Bulletin de la Société belge d'ophtalmologie. (1995) [Pubmed]
  24. Correlation between angiotensin-converting enzyme, vascular endothelial growth factor, and matrix metalloproteinase-9 in the vitreous of eyes with diabetic retinopathy. Ishizaki, E., Takai, S., Ueki, M., Maeno, T., Maruichi, M., Sugiyama, T., Oku, H., Ikeda, T., Miyazaki, M. Am. J. Ophthalmol. (2006) [Pubmed]
  25. Angiopoietin concentrations in diabetic retinopathy. Patel, J.I., Hykin, P.G., Gregor, Z.J., Boulton, M., Cree, I.A. The British journal of ophthalmology. (2005) [Pubmed]
  26. Increased soluble interleukin-6 receptor in vitreous fluid of proliferative vitreoretinopathy. Yamamoto, H., Hayashi, H., Uchida, H., Kato, H., Oshima, K. Curr. Eye Res. (2003) [Pubmed]
  27. Retinal complications after cataract extraction in patients with high myopia. Fan, D.S., Lam, D.S., Li, K.K. Ophthalmology (1999) [Pubmed]
  28. Vitreoretinal surgery for macular hole after laser assisted in situ keratomileusis for the correction of myopia. Arevalo, J.F., Rodriguez, F.J., Rosales-Meneses, J.L., Dessouki, A., Chan, C.K., Mittra, R.A., Ruiz-Moreno, J.M. The British journal of ophthalmology. (2005) [Pubmed]
  29. Unbalanced vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy. Ogata, N., Nishikawa, M., Nishimura, T., Mitsuma, Y., Matsumura, M. Am. J. Ophthalmol. (2002) [Pubmed]
  30. Spontaneous closure of traumatic macular hole. Yamada, H., Sakai, A., Yamada, E., Nishimura, T., Matsumura, M. Am. J. Ophthalmol. (2002) [Pubmed]
  31. Combined macular hole and cataract surgery. Miller, J.H., Googe, J.M., Hoskins, J.C. Am. J. Ophthalmol. (1997) [Pubmed]
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