Disease relevance of PGE

• Transcutol was assessed for its antiproliferative effects on YAC lymphoma and P-815 mastocytoma human cell lines [1].

High impact information on PGE

• The effect of the penetration enhancers Transcutol, 2-pyrrolidone, and polyethylene glycol 600 was evaluated [2].
• Similarly, our data demonstrate that Transcutol does not independently interact with membranes [3].
• 0. A different trend was observed in experiments with 2% oleate in Transcutol (2% O-TC), where skin flux was maximal at a more basic pH, when the degree of ionization is low [4].
• The study also aimed at optimising the permeability of the S. desoleana essential oil by means of an enhancer, the diethylene glycol monoethyl ether Transcutol [5].
• For the Transcutol formulation the area under the blood concentration-time curve (0-96 h) was 6.06 +/- 1.27 compared with 2.52 +/- 0.43 x 10(6) d min-1 mL-1 h for the control formulation, indicating a 58% reduction in body burden [6].

Biological context of PGE

• The purpose of this work was to analyse the mechanism of the enhancement of percutaneous penetration demonstrated by the known enhancers Azone and Transcutol [7].
• Transcutol inhibited cell proliferation of both these cell lines, being more effective towards P-815 mastocytoma (at 2 mM it displayed 3.95-fold vs. 2.4-fold inhibition towards YAC lymphoma) [1].

Anatomical context of PGE

• In conclusion, we have shown that Transcutol has antiproliferative effects on 3T3 murine, human normal and psoriatic fibroblasts and tumour cell lines [1].

Associations of PGE with other chemical compounds

• A different trend was found in experiments with gels containing mixtures of the two enhancers, where an increase (in the case of artificial membrane) or a decrease (in the case of rabbit ear skin) of drug permeation was found by increasing the transcutol/propylene glycol ratio in the mixture [8].
• The objective of this study was to determine the penetration of sodium naproxen, formulated in Pluronic F-127 (PF-127) gels containing Azone and Transcutol as penetration enhancers, through human skin in vivo [9].
• A topical delivery system was developed with and without TC and was evaluated in vivo using the rat as an animal model for hydrocortisone accumulation after multiple dosing [10].
• Two-phase solvent desorption with CS2 and water allows aqueous phase recoveries of DOWANOL EM, PM, EE, DM, DPM, and TM glycol ethers [11].

Analytical, diagnostic and therapeutic context of PGE

• Our purpose was to explore the use of Transcutol P (Trans) in an ocular drug delivery system [12].

References