Disease relevance of NSC517936

• Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. Acute Renal Failure Investigation Team [1].
• Metabolic acidosis in diethylene glycol poisoning [2].
• Photodynamic efficiency of diethylene glycol-linked glycoconjugated porphyrins in human retinoblastoma cells [3].
• The other isolate, identified as a Bacteroides sp. (strain PG1), metabolized diethylene glycol and polymers of PEG up to an average molecular mass of 20,000 g/mol [PEG 20000; HO-(CH2-CH2-O-)nH] [4].
• Initially we suspected that the build-up of diethylene glycol in these patients was caused by schistosomiasis infection [5].

High impact information on NSC517936

• Functionalized N-2-mercaptoethyl-gallamides bearing three or five hydroxyl units that are tethered with diethylene glycol ether(s) allow for transferring hydrophobically pyridine-capped CdSe/ZnS core/shell nanoparticles from an organic to an aqueous layer with intact fluorescent profiles [6].
• In this method, gradient-separated leukocytes or unseparated blood or bone marrow cells were incubated in a commercially available diethylene glycol-based red blood cell lysing solution, which not only lyses red blood cells, but also permeabilizes leukocyte cell membranes; the light scattering properties of the cells are retained [7].
• Using diethylene glycol-mediated erythrocyte lysis, perforin was well preserved to be readily detectable by immuno flow cytometry [8].
• Thus, poisoning with diethylene glycol seems to be the cause of acute renal failure in these children [9].
• Determination of diethylene glycol in wine by high-performance liquid chromatography using anthracene-9-carbonyl chloride as a derivatizing reagent [10].

Chemical compound and disease context of NSC517936

• Other studies have demonstrated that testicular atrophy or infertility follow treatment of males with EGME, ethylene glycol monomethyl ether acetate (EGMEA), EGEE, EGEEA, diethylene glycol dimethyl ether (diEGdiME), and diethylene glycol monoethyl ether (diEGEE) [11].
• The comparative acute toxicity and primary irritancy of the monohexyl ethers of ethylene and diethylene glycol [12].
• The developmental toxicity of diethylene glycol dimethyl ether in mice [13].
• Fatal renal failure caused by diethylene glycol in paracetamol elixir: the Bangladesh epidemic [14].
• The objective of this study was to investigate the effect of a potent PAF-antagonist (Ro 24-0238, 10% solution in diethylene glycol monoethyl ether) in 10 patients with chronic plaque psoriasis, a placebo-controlled double-blind study [15].

Biological context of NSC517936

• The method, which is relatively specific, involves enzyme hydrolysis of urine samples a number of classical extraction and purification steps, and analysis of the silylated estrogens on a 2.7-m, 1.7% diethylene glycol succinate column using flame-ionization detection [16].
• Among the enhancers studied, diethylene glycol showed the greatest enhancing effects on drug permeation through skin [17].
• Toxicokinetics of diethylene glycol (DEG) in the rat [18].
• Embedment in diethylene glycol distearate (DGD) was shown to be highly desirable and versatile for retinal cytochemical studies, including in situ hybridization, immuno- and lectin cytochemistry [19].
• Diethylene glycol monomethyl ether, ethylene glycol monomethyl ether and the metabolite, 2-methoxyacetic acid affect in vitro chondrogenesis [20].

Anatomical context of NSC517936

• The results showed that to achieve diethylene glycol biodegradation with these inocula, a number of 10(5) colony-forming units per milliliter of effective degrader microorganisms had to be present [21].
• The myocardium of guinea pigs fed on sublethal doses of diethylene glycol (DEG) over a period of 2-11 days was examined for microscopical and ultrastructural changes [22].
• On the other hand, while the reappearance of blastocoele and expansion of blastocysts after 48 h of post-thaw culture were not significantly different among each cryoprotectant, the percentage of hatching blastocysts were significantly different between DEG and EME (P<0.05), between DEG and EG (P<0.01) and between PG and EG (P<0.05) [23].
• Fetal detriment used as an index of effects of diethylene glycol on Syrian hamster fetuses [24].
• It was shown that DMSO and diethylene glycol monoethyl ether altered cutaneous microcirculation and thus MN penetration in comparison to the standard formulation [25].

Associations of NSC517936 with other chemical compounds

• During PEG biodegradation, their chains are shortened leading to the formation of ethylene glycol and diethylene glycol [26].
• Using this method, diethylene glycol dimethyl ether and diethylene glycol diethyl ether were detected and measured successfully in diluted vehicle exhausts in diesel fuel engine tests [27].
• Pregnancy rates resulting from embryos frozen in the different cryoprotectants were as follows: MC (48%, 10 21 ); DEG (30%, 3 10 ); EG (74%, 20 27 ); and PG (40%, 4 10 ) [28].
• Hypericin (0.01-1.0%) in Beeler basis, polyethylene glycol ointment, carbopol gel, cetomacrogol cream, petrolatum or emulsifying ointment, with and without skin-absorption enhancers (isopropylidene glycerol and diethylene glycol monoethyl ether), was tested in-vivo on hairless mice skin [29].
• Between June and September 1990, 47 children died at Jos University Teaching Hospital, Nigeria from ingestion of paracetamol syrup adulterated with diethylene glycol [30].

Gene context of NSC517936

• Identification of diethylene glycol in sera from Egyptian children by frequency-pulsed electron-capture gas-liquid chromatography [5].
• The enhancers dimethyl sulfoxide, diethylene glycol monoethyl ether and three different glycerides in different concentrations were added to MCT as a standard vehicle [31].

Analytical, diagnostic and therapeutic context of NSC517936

• Diethylene glycol distearate is used as a removable embedding medium to produce embeddment -free sections for transmission electron microscopy [32].
• Determination of diethylene glycol in wine. Rapid purification with a Carbopack B cartridge and quantitation by gas chromatography [33].
• Simplified routine method for the determination of diethylene glycol in wines by capillary gas chromatography with flame ionization detection [34].
• A newly synthesized diethylene glycol functionalized chlorin-type photosensitizer, lemuteporfin, was characterized for use in photodynamic therapy (PDT) in a panel of in vitro and in vivo test systems [35].
• 2. Ethylene and diethylene glycol in rat blood stored under refrigeration at 4 degrees +/- 10 degrees C for a period of 30 days exhibited minimal concentration losses, contrary to previous reports [36].

References