Disease relevance of 28472-37-9

• Muscle fructose-2,6-bisphosphate and glucose-1,6-bisphosphate during insulin-induced hypoglycemia [1].

High impact information on 28472-37-9

• We report the crystallization and structure determination to 2.1 A of L. mexicana PMM alone and in complex with glucose-1,6-bisphosphate to 2.9 A [2].
• Phosphoglycerates and protein phosphorylation: identification of a protein substrate as glucose-1,6-bisphosphate synthetase [3].
• Effect of vanadate on the glucose-1,6-bisphosphate synthase and glucose-1,6-bisphosphatase activities of phosphoglucomutase [4].
• Fasting-induced impairment of glucose-1,6-bisphosphate synthesis in pancreatic islets [5].
• Glucose-induced accumulation of glucose-1,6-bisphosphate in pancreatic islets : its possible role in the regulation of glycolysis [6].

Biological context of 28472-37-9

• Glucose-1,6-bisphosphate (Glc-1,6-P2), the powerful regulator of carbohydrate metabolism, was markedly decreased in liver of adult rats (2 months of age) as compared to young rats (1-2 weeks of age) [7].

Anatomical context of 28472-37-9

• Under the experimental conditions used to separate erythrocytes by age the comparison of the younger erythrocytes with the older shows that total phosphoglucomutase, phosphoribomutase and glucose-1,6-bisphosphate synthetic activities decay by 55%, 26% and 28%, respectively [8].

Associations of 28472-37-9 with other chemical compounds

• With regard to the phosphoglucomutase PGM1 and PGM2 isoenzymes, the latter appear to be more important in erythrocyte metabolism owing to their ability to mutate ribose monophosphates and synthetize glucose-1,6-bisphosphate [8].
• Effects of epinephrine on glucose-1,6-bisphosphate and carbohydrate metabolism in skin [9].
• Intercept inhibition of rabbit-muscle phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate: alpha-D-glucose-1-phosphate phosphotransferase, EC 2.7.5.1) produced by several nucleotide diphosphates and compounds related to coenzyme A was re-examined in order to re-evaluate an earlier suggestion that this enzyme has an allosteric regulatory site [10].

Gene context of 28472-37-9

• The process of glucose-1,6-bisphosphate synthesis, as catalyzed by the alpha-stereospecific phosphoglucomutase, may play a role in the metabolic and, hence, secretory responses of the islets to glucose epimers and anomers [11].
• Mitochondrial and soluble Type I and Type II hexokinase from various rat tissues differed in their susceptibility to inhibition by glucose-1,6-bisphosphate (Glc-1,6-P2) [12].
• 2. The CaM antagonists raised the decreased glucose-1,6-bisphosphate levels, induced by high Ca2+, with a concomitant activation of the reduced cytosolic phosphofructokinase (the rate limiting enzyme of glycolysis) and thereby cytosolic glycolysis [13].

References