Disease relevance of DL-alpha-Tocopheryl acetate

• Response to a single oral dose of all-rac-alpha-tocopheryl acetate in patients with cystic fibrosis and in healthy individuals [1].
• The response to a single oral dose of all-rac-alpha-tocopheryl acetate [100 IU (100 mg)/kg body wt] was studied over 24 h in 25 CF patients with exocrine pancreatic insufficiency and in 23 healthy individuals [1].
• High energy metabolites were measured in the adductor magnus muscle of untreated animals and compared to the treatment group (all rac-alpha-tocopheryl acetate, 3 mg/kg body weight, supplemented i.v. before the onset of ischemia) [2].

High impact information on DL-alpha-Tocopheryl acetate

• In a randomized, crossover study subjects underwent two 4-week treatments (400 mg/day) with undeuterated RRR- and all rac-alpha-tocopheryl acetate around a 12-week washout [3].
• One investigation showed that the use of 2000 IU all-rac-alpha-tocopheryl acetate is beneficial in the treatment of Alzheimer disease [4].
• The bioavailability of RRR-alpha-tocopherol was greater than that of all-rac-alpha-tocopheryl acetate [5].
• In vitamin E deficiency an efficient delivery of a high oral loading dose of all-rac-alpha-tocopheryl acetate to erythrocyte membranes could provide an early onset antioxidative effect [6].
• In this longitudinal study, the effects of repleting rats with a diet containing 36 mg/kg all-rac-alpha-tocopheryl acetate for 20 wk after they had been receiving a vitamin E-deficient diet for 38 wk was studied [7].

Chemical compound and disease context of DL-alpha-Tocopheryl acetate

• Long-term oral vitamin E supplementation in cystic fibrosis patients: RRR-alpha-tocopherol compared with all-rac-alpha-tocopheryl acetate preparations [8].
• We investigated short-term changes in erythrocyte alpha-tocopherol after a single oral dose of 100 mg all-rac-alpha-tocopheryl acetate/kg in 10 vitamin E-deficient cystic fibrosis (CF) patients [6].
• PROCEDURE: 3 and 1.5 weeks before calving, sodium selenite (5 mg/100 kg of body weight) and d,l-alpha-tocopheryl acetate (25 IU/100 kg) were administered to 13 cows [9].

Biological context of DL-alpha-Tocopheryl acetate

• Relative bioavailability of RRR- and all-rac-alpha-tocopheryl acetate in humans: studies using deuterated compounds [10].
• Bioequivalence of RRR-alpha-tocopheryl acetate and all-rac-alpha-tocopheryl acetate [11].
• Antibody production against sheep RBC was highest in rats fed the FO diet supplemented with 900 mg all-rac-alpha-tocopheryl acetate/kg of diet [12].
• Healthy men (n = 10) carrying the apolipoprotein (apo)E4 genotype completed a randomized crossover study, comprised of two 4-wk treatments with 400 mg/d (RRR-alpha-tocopheryl and all-rac-alpha-tocopheryl acetate) with a 12-wk washout period between treatments [13].

Anatomical context of DL-alpha-Tocopheryl acetate

• This study examined the influence of different dietary fat sources (animal fat, sunflower oil, and fish oil) and supplementation of vitamin E (85, 150 and 300mg all-rac-alpha-tocopheryl acetate/kg diet) on the ex vivo synthesis of eicosanoids and cytokines by porcine alveolar macrophages [14].

Associations of DL-alpha-Tocopheryl acetate with other chemical compounds

• Vitamin E was administered orally (400 IU twice a day) to adult male humans for 28 days as either dl-alpha-tocopheryl acetate (all-rac-alpha-tocopheryl acetate) or d-alpha-tocopheryl acetate (RRR-alpha-tocopheryl acetate) [15].
• Guinea pigs were fed semipurified diets with 0.2 g/kg vitamin C and either 0, 30 or 200 mg/kg all-rac-alpha-tocopheryl acetate or 10 mg/kg vitamin C and either 0, 30 or 200 mg/kg all-rac-alpha-tocopheryl acetate for 4 weeks [16].
• Six GPX1(-) and four control mice (5 wk old, half males and females) were fed the basal diet supplemented with 0.2 mg Se/kg and 15 mg of all-rac-alpha-tocopheryl acetate/kg for 5 wk [17].
• Selective biodiscrimination of alpha-tocopherol stereoisomers. Similar enrichment of all 2R forms in rat tissues after oral all-rac-alpha-tocopheryl acetate [18].
• Recoveries were determined on an analyte-fortified zero control reference material for milk-based infant formula and averaged 96.8% (n = 30) for retinyl palmitate and 91.5% (n = 25) for all-rac-alpha-tocopheryl acetate [19].

Gene context of DL-alpha-Tocopheryl acetate

• Supplementation of 150 mg/kg of all-rac-alpha-tocopheryl acetate to the L15 diet slightly decreased the TBARS in plasma, heart and liver and restored the depressed activities of RBC superoxide dismutase and catalase [20].
• METHODS: Three-month-old MRL/lymphoproliferative lpr female mice were fed an AIN-76 diet containing 50 mg/kg (control), 250 mg/kg (E5), 375 mg/kg (E7.5), or 500 mg/kg (E10) all-rac-alpha-tocopheryl acetate [21].
• My valedictory on the differences in biological potency between RRR-alpha-tocopheryl and all-rac-alpha-tocopheryl acetate [22].
• The effect of the addition of dietary ascorbic acid and/or vitamin E (all-rac-alpha-tocopheryl acetate) in rats and guinea pigs exposed to PCB (polychlorinated biphenyls) was studied [23].
• First, 5-month-old mice were fed an AIN-76 diet containing either 150 g fresh soyabean oil/kg (15S), 50 g fresh soyabean oil/kg + 100 g oxidised frying oil/kg (5S10F) or 5S10F supplemented with all-rac-alpha-tocopheryl acetate at 275 mg/kg diet level (5S10F5E) or 550 mg/kg (5S10F10E), respectively, in experiment 1 [24].

References