Disease relevance of NSC 4738

• Systemic contact dermatitis after inhalation of 2-aminothiophenol [1].
• Exposure-pattern dermatitis due to 2-aminothiophenol and 2-aminophenyldisulfide [2].
• Occupational airborne allergic contact dermatitis from 2-aminothiophenol [3].

High impact information on NSC 4738

• Inactivation of yeast hexokinase by 2-aminothiophenol. Evidence for a 'half-of-the-sites' mechanism [4].
• Hexokinase that had been completely inactivated by 2-aminothiophenol reacted with o-phthalaldehyde [4].
• Dithiothreitol, 2-mercaptoethanol and cysteine restored the phosphotransferase activity of the hexokinase after inactivation by 2-aminothiophenol [4].
• Thus it is concluded that the inactivation of the hexokinase by 2-aminothiophenol was a consequence of a covalent disulphide bond formation between the aminothiol and thiol function at or near the active site of the enzyme [4].
• Among a variety of compounds, structurally related to CySH 4-aminothiophenol, 2-aminothiophenol and N,N-dimethylaminothiol exhibited the highest efficacy in decreasing somatostatin (60%, 50%, 30%, respectively, at 10 mM and 10 min) [5].

Biological context of NSC 4738

• The complex [VO(Cl)S'NS'] (5; H(2)S'NS' is the Schiff base formed between o-mercaptoaniline and o-mercaptobenzaldehyde) is obtained by redox interaction between [VCl(3)(THF)(3)] and 2,2'-dithiodibenzaldehyde in the presence of o-mercaptoaniline.The crystal and molecular structures have been obtained for 3 [6].

Associations of NSC 4738 with other chemical compounds

• Fluorescence assay of nitrofurantoin with o-aminothiophenol in plasma and urine [7].
• Synthesis of radiolabeling precursors and the reference standards 5- and 6-fluorinated arylbenzothiazoles (11c-n) was achieved via the reaction of o-aminothiophenol disulfides with substituted benzaldehydes under reducing conditions [8].

Gene context of NSC 4738

• The gold(I) thiolate complexes [Au(2-SC6H4NH2)(PPh3)] (1), [PPN][Au(2-SC6H4NH2)2] (2) (PPN = PPh3=N=PPh3), and [{Au(2-SC6H4NH2)}2(mu-dppm)] (3) (dppm = PPh2CH2PPh2) have been prepared by reaction of acetylacetonato gold(I) precursors with 2-aminobenzenethiol in the appropriate molar ratio [9].

References