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Chemical Compound Review:

Isopalm propan-2-yl hexadecanoate

Synonyms: Deltyl, Isopal, Propal, Emcol-IP, Sinnoester PIT, ...

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Disease relevance of palmitic acid isopropyl ester

A repeat-batch membrane bioreactor with a phase inversion for the desaturation of isopropyl palmitate by a mutant Rhodococcus strain [1].
The D-value method was used to assess the antimicrobial activity of isopropyl palmitate, ethyl myristate, ethyl laurate and isopropyl myristate against Pseudomonas aeruginosa [2].
In this study, six fatty acid esters (diethyl adipate, diisopropyl adipate, ethyl laurate, ethyl myristate, methyl caprylate and isopropyl palmitate) were evaluated as solvents to replace isopropyl myristate in the sterility test for ophthalmic ointments [2].
In the acute irritation test, discrete irritation (erythema only) developed with the gel in 2 subjects (1.3%), with the liposomes in 3 subjects (2.0%), and with IPP in 2 subjects (1.3%) [3].

High impact information on palmitic acid isopropyl ester

We separated isoenzymes of alkaline phosphatase (ALP; EC 3.1.3.1) in 1383 sera of normal individuals (ages 4-65 years) by agarose electrophoresis with the Isopal system (Analis) [4].
Other permeation enhancers commonly used in transdermal formulations are isopropyl myristate, isopropyl palmitate, triacetin, isostearylic isostearate, R(+)-limonene and medium chain triglycerides [5].
The addition of isopropyl palmitate, oleic acid, or glyceryl trioleate, 0.6-1.2% v/v to the micellar systems, led to an increase of the substrate concentration in the solution and particularly its bioavailability, allowing faster catalytic conversions [6].
The formulations were a basic cream, a carbomer cream and four modifications of the carbomer cream, containing either 10% isopropyl palmitate (IPP cream), 10% glycerol (glycerol cream), 19.5% canola oil (canola oil cream) or 0.5% (-)-alpha-bisabolol (bisabolol cream) [7].
Studies on the kinetics of Isopropyl Palmitate synthesis in packed bed bioreactor using immobilized lipase [8].

Analytical, diagnostic and therapeutic context of palmitic acid isopropyl ester

A repeat-batch membrane bioreactor was constructed for the novel bioconversion of isopropyl hexadecanoate to isopropyl cis-6-hexadecenoate by a Rhodococcus mutant [1].

References

A repeat-batch membrane bioreactor with a phase inversion for the desaturation of isopropyl palmitate by a mutant Rhodococcus strain. Koike, K., Takeuchi, K., Mino, H., Takaiwa, M., Tohoh, T., Tadokoro, T., Tsutoh, K., Ito, S. J. Biotechnol. (2000) [Pubmed]
Investigation of fatty acid esters to replace isopropyl myristate in the sterility test for ophthalmic ointments. Cardoso, V.M., Solano, A.G., Prado, M.A., Nunan, E.d.e. .A. Journal of pharmaceutical and biomedical analysis. (2006) [Pubmed]
Human skin irritation studies of a lecithin microemulsion gel and of lecithin liposomes. Dreher, F., Walde, P., Luisi, P.L., Elsner, P. Skin Pharmacol. (1996) [Pubmed]
Age and sex distribution of alkaline phosphatase isoenzymes by agarose electrophoresis. Van Hoof, V.O., Hoylaerts, M.F., Geryl, H., Van Mullem, M., Lepoutre, L.G., De Broe, M.E. Clin. Chem. (1990) [Pubmed]
Microemulsions as transdermal drug delivery vehicles. Kogan, A., Garti, N. Advances in colloid and interface science (2006) [Pubmed]
Direct micellar systems as a tool to improve the efficiency of aromatic substrate conversion for fine chemicals production. Berti, D., Randazzo, D., Briganti, F., Baglioni, P., Scozzafava, A., Di Gennaro, P., Galli, E., Bestetti, G. J. Inorg. Biochem. (2000) [Pubmed]
The hairless guinea-pig as a model for treatment of cumulative irritation in humans. Andersen, F., Hedegaard, K., Petersen, T.K., Bindslev-Jensen, C., Fullerton, A., Andersen, K.E. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). (2006) [Pubmed]
Studies on the kinetics of Isopropyl Palmitate synthesis in packed bed bioreactor using immobilized lipase. Kee, C.Y., Hassan, M., Ramachandran, K.B. Artificial cells, blood substitutes, and immobilization biotechnology. (1999) [Pubmed]

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