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Chemical Compound Review

THDOC     2-hydroxy-1- [(5R,8S,9S,10S,13S,14S,17S)- 3...

Synonyms: SureCN597740, LS-175768, AC1L3M5G, C21H34O3, 567-03-3, ...
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Disease relevance of EINECS 209-301-3


High impact information on EINECS 209-301-3

  • In studying the levels of the mineralocorticoids, there was shown to be an increased basal level of tetrahydrodeoxycorticosterone (patients, 142-317 microgram/24 h; normal, 60-80 microgram/24 h) which was raised by ACTH stimulation [4].
  • 1. The effects of the naturally occurring neurosteroid tetrahydrodeoxycorticosterone (THDOC) on GABAA receptor-mediated miniature, spontaneous and evoked IPSCs was tested using patch-clamp techniques in slices of hippocampus and cerebellum from rats at two developmental stages ( approximately 10 and approximately 20 days postnatal) [5].
  • Inhibition by alpha-Tetrahydrodeoxycorticosterone (THDOC) of Pre-Sympathetic Parvocellular Neurones in the Paraventricular Nucleus of Rat Hypothalamus [6].
  • In order to address this issue, gas chromatography/mass spectrometry was used to measure the neurosteroids pregnenolone, allopregnanolone, and tetrahydrodeoxycorticosterone (THDOC) in postmortem brain tissue from controls, cirrhotic patients who died without HE, a patient who died in uremic coma, and cirrhotic patients who died in hepatic coma [7].
  • The neurosteroids tetrahydroprogesterone and tetrahydrodeoxycorticosterone increased [3H]GABA binding to hydra membranes with nanomolar potency (EC50, 141+/-11 and 623+/-36 nM, respectively) and high efficacy (maximal increase 79+/-6.5 and 62+/-4%, respectively), whereas the 3beta-hydroxy epimer of tetrahydroprogesterone was ineffective [8].

Biological context of EINECS 209-301-3


Associations of EINECS 209-301-3 with other chemical compounds


Gene context of EINECS 209-301-3


  1. Fecal steroid 21-dehydroxylase, a potential marker for colorectal cancer. Bokkenheuser, V.D., Winter, J., Mosenthal, A.C., Mosbach, E.H., McSherry, C.K., Ayengar, N.K., Andrews, A.W., Lebherz, W.B., Pienta, R.J., Wallenstein, S. Am. J. Gastroenterol. (1983) [Pubmed]
  2. Neuroactive steroids exacerbate gamma-hydroxybutyric acid-induced absence seizures in rats. Banerjee, P.K., Snead, O.C. Eur. J. Pharmacol. (1998) [Pubmed]
  3. Ammonia, the GABA neurotransmitter system, and hepatic encephalopathy. Jones, E.A. Metabolic brain disease. (2002) [Pubmed]
  4. Adrenocortical 11 beta-hydroxylation defect in adult women with postmenarchial onset of symptoms. Cathelineau, G., Brerault, J.L., Fiet, J., Julien, R., Dreux, C., Canivet, J. J. Clin. Endocrinol. Metab. (1980) [Pubmed]
  5. Effects of a naturally occurring neurosteroid on GABAA IPSCs during development in rat hippocampal or cerebellar slices. Cooper, E.J., Johnston, G.A., Edwards, F.A. J. Physiol. (Lond.) (1999) [Pubmed]
  6. Inhibition by alpha-Tetrahydrodeoxycorticosterone (THDOC) of Pre-Sympathetic Parvocellular Neurones in the Paraventricular Nucleus of Rat Hypothalamus. Womack, M.D., Pyner, S., Barrett-Jolley, R. Br. J. Pharmacol. (2006) [Pubmed]
  7. Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma. Ahboucha, S., Pomier-Layrargues, G., Mamer, O., Butterworth, R.F. Neurochem. Int. (2006) [Pubmed]
  8. Modulation of gamma-aminobutyric acid (GABA) receptors and the feeding response by neurosteroids in Hydra vulgaris. Concas, A., Pierobon, P., Mostallino, M.C., Porcu, P., Marino, G., Minei, R., Biggio, G. Neuroscience (1998) [Pubmed]
  9. Effects of adrenocortical steroids on long-term potentiation in the limbic system: basic mechanisms and behavioral consequences. Dubrovsky, B., Gijsbers, K., Filipini, D., Birmingham, M.K. Cell. Mol. Neurobiol. (1993) [Pubmed]
  10. Steroid-inhibition of [3H]gamma-hydroxybutyric acid (GHB) binding in thalamic relay nuclei increases during absence seizures. Banerjee, P.K., Liu, C.C., Snead, O.C. Brain Res. (1998) [Pubmed]
  11. Neurosteroids, neuroactive steroids, and symptoms of affective disorders. Dubrovsky, B. Pharmacol. Biochem. Behav. (2006) [Pubmed]
  12. Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit. Wohlfarth, K.M., Bianchi, M.T., Macdonald, R.L. J. Neurosci. (2002) [Pubmed]
  13. Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes. Bender, A.S., Norenberg, M.D. J. Neurosci. Res. (1998) [Pubmed]
  14. Biochemical and behavioral effects of steroids on GABAA receptor function in long- and short-sleep mice. Bowers, B.J., Wehner, J.M. Brain Res. Bull. (1992) [Pubmed]
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