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MeSH Review

Epilepsy, Absence

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Disease relevance of Epilepsy, Absence


Psychiatry related information on Epilepsy, Absence


High impact information on Epilepsy, Absence


Chemical compound and disease context of Epilepsy, Absence


Biological context of Epilepsy, Absence


Anatomical context of Epilepsy, Absence


Gene context of Epilepsy, Absence

  • Absence seizures were observed in combination with the stargazer 3J mutation, which itself does not have seizures, and increased seizure activity was observed in combination with the waggler allele [11].
  • In genetic mouse models, mGlu1/5 antagonists and mGlu2/3 agonists are effective against absence seizures [26].
  • Mutation screen of GABRA1, GABRB2 and GABRG2 genes in Japanese patients with absence seizures [27].
  • The results suggest that the change of neuropeptide levels, most conspicuous in NPY among three peptides tested, may be involved in the phenotypical manifestation of seizures in SER and tremor rats, and that the development of tonic convulsion and absence seizures may be differently associated with the change of brain neuropeptide levels [28].
  • SCN1B mutations are associated with GEFS+ and may have a role in the elicitation of absence seizures [29].

Analytical, diagnostic and therapeutic context of Epilepsy, Absence


  1. Absence epilepsy in tottering mutant mice is associated with calcium channel defects. Fletcher, C.F., Lutz, C.M., O'Sullivan, T.N., Shaughnessy, J.D., Hawkes, R., Frankel, W.N., Copeland, N.G., Jenkins, N.A. Cell (1996) [Pubmed]
  2. A profile of alternative RNA splicing and transcript variation of CACNA1H, a human T-channel gene candidate for idiopathic generalized epilepsies. Zhong, X., Liu, J.R., Kyle, J.W., Hanck, D.A., Agnew, W.S. Hum. Mol. Genet. (2006) [Pubmed]
  3. Childhood absence epilepsy and febrile seizures: a family with a GABA(A) receptor mutation. Marini, C., Harkin, L.A., Wallace, R.H., Mulley, J.C., Scheffer, I.E., Berkovic, S.F. Brain (2003) [Pubmed]
  4. Syncopal attacks compulsively self-induced by Valsalva's maneuver associated with typical absence seizures. A case report. Aicardi, J., Gastaut, H., Misès, J. Arch. Neurol. (1988) [Pubmed]
  5. Relations between cortical and thalamic cellular activities during absence seizures in rats. Seidenbecher, T., Staak, R., Pape, H.C. Eur. J. Neurosci. (1998) [Pubmed]
  6. Modulation of absence seizures by the GABA(A) receptor: a critical rolefor metabotropic glutamate receptor 4 (mGluR4). Snead, O.C., Banerjee, P.K., Burnham, M., Hampson, D. J. Neurosci. (2000) [Pubmed]
  7. Prolactin-releasing peptide (PrRP) promotes awakening and suppresses absence seizures. Lin, S.H., Arai, A.C., España, R.A., Berridge, C.W., Leslie, F.M., Huguenard, J.R., Vergnes, M., Civelli, O. Neuroscience (2002) [Pubmed]
  8. Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life. Ferreira, B.L., Valle, A.C., Cavalheiro, E.A., Timo-Iaria, C. Braz. J. Med. Biol. Res. (2003) [Pubmed]
  9. A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group. Mattson, R.H., Cramer, J.A., Collins, J.F. N. Engl. J. Med. (1992) [Pubmed]
  10. Anticonvulsants specific for petit mal antagonize epileptogenic effect of leucine enkephalin. Snead, O.C., Bearden, L.J. Science (1980) [Pubmed]
  11. A targeted mutation in Cacng4 exacerbates spike-wave seizures in stargazer (Cacng2) mice. Letts, V.A., Mahaffey, C.L., Beyer, B., Frankel, W.N. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  12. Emergent spindle oscillations and intermittent burst firing in a thalamic model: specific neuronal mechanisms. Wang, X.J., Golomb, D., Rinzel, J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  13. Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Coulter, D.A., Huguenard, J.R., Prince, D.A. Ann. Neurol. (1989) [Pubmed]
  14. Ganaxolone, a selective, high-affinity steroid modulator of the gamma-aminobutyric acid-A receptor, exacerbates seizures in animal models of absence. Snead, O.C. Ann. Neurol. (1998) [Pubmed]
  15. Inhibitory effects of anticonvulsant drugs on cyclic nucleotide accumulation in brain. Ferrendelli, J.A., Kinscherf, D.A. Ann. Neurol. (1979) [Pubmed]
  16. Chromosomal investigations in children with pyknolepsy on dipropylacetate monotherapy. Kotlarek, F., Faust, J. Hum. Genet. (1978) [Pubmed]
  17. Gamma-hydroxybutyrate promotes oscillatory activity of rat and cat thalamocortical neurons by a tonic GABAB, receptor-mediated hyperpolarization. Williams, S.R., Turner, J.P., Crunelli, V. Neuroscience (1995) [Pubmed]
  18. Relation of the [3H] gamma-hydroxybutyric acid (GHB) binding site to the gamma-aminobutyric acidB (GABAB) receptor in rat brain. Snead, O.C. Biochem. Pharmacol. (1996) [Pubmed]
  19. Alterations in GABAA receptor alpha 1 and alpha 4 subunit mRNA levels in thalamic relay nuclei following absence-like seizures in rats. Banerjee, P.K., Tillakaratne, N.J., Brailowsky, S., Olsen, R.W., Tobin, A.J., Snead, O.C. Exp. Neurol. (1998) [Pubmed]
  20. Involvement of the thalamocortical system in epileptic loss of consciousness. Kostopoulos, G.K. Epilepsia (2001) [Pubmed]
  21. Neural network of structures in which GABAB receptors regulate absence seizures in the lethargic (lh/lh) mouse model. Hosford, D.A., Lin, F.H., Kraemer, D.L., Cao, Z., Wang, Y., Wilson, J.T. J. Neurosci. (1995) [Pubmed]
  22. Extracellular GABA in the ventrolateral thalamus of rats exhibiting spontaneous absence epilepsy: a microdialysis study. Richards, D.A., Lemos, T., Whitton, P.S., Bowery, N.G. J. Neurochem. (1995) [Pubmed]
  23. Hippocampal extracellular amino acids and EEG spectral analysis in a genetic rat model of absence epilepsy. Richards, D.A., Morrone, L.A., Bowery, N.G. Neuropharmacology (2000) [Pubmed]
  24. Regulation of gamma-aminobutyric acid (GABA) release in cerebral cortex in the gamma-hydroxybutyric acid (GHB) model of absence seizures in rat. Hu, R.Q., Banerjee, P.K., Snead, O.C. Neuropharmacology (2000) [Pubmed]
  25. Dopamine in the striatum modulates seizures in a genetic model of absence epilepsy in the rat. Deransart, C., Riban, V., Lê, B., Marescaux, C., Depaulis, A. Neuroscience (2000) [Pubmed]
  26. Glutamate metabotropic receptors as targets for drug therapy in epilepsy. Moldrich, R.X., Chapman, A.G., De Sarro, G., Meldrum, B.S. Eur. J. Pharmacol. (2003) [Pubmed]
  27. Mutation screen of GABRA1, GABRB2 and GABRG2 genes in Japanese patients with absence seizures. Ito, M., Ohmori, I., Nakahori, T., Ouchida, M., Ohtsuka, Y. Neurosci. Lett. (2005) [Pubmed]
  28. Altered brain contents of neuropeptides in spontaneously epileptic rats (SER) and tremor rats with absence seizures. Sadamatsu, M., Kanai, H., Masui, A., Serikawa, T., Yamada, J., Sasa, M., Kato, N. Life Sci. (1995) [Pubmed]
  29. A deletion in SCN1B is associated with febrile seizures and early-onset absence epilepsy. Audenaert, D., Claes, L., Ceulemans, B., Löfgren, A., Van Broeckhoven, C., De Jonghe, P. Neurology (2003) [Pubmed]
  30. Long-term prognosis in two forms of childhood epilepsy: typical absence seizures and epilepsy with rolandic (centrotemporal) EEG foci. Loiseau, P., Pestre, M., Dartigues, J.F., Commenges, D., Barberger-Gateau, C., Cohadon, S. Ann. Neurol. (1983) [Pubmed]
  31. Brain sterols in the AY-9944 rat model of atypical absence seizures. Cortez, M.A., Cunnane, S.C., Snead, O.C. Epilepsia (2002) [Pubmed]
  32. Thalamic NMDA receptors in the gamma-hydroxybutyrate model of absence seizures: a cerebral microinjection study in rats. Banerjee, P.K., Snead, O.C. Neuropharmacology (1995) [Pubmed]
  33. fMRI of generalized absence status epilepticus in conscious marmoset monkeys reveals corticothalamic activation. Tenney, J.R., Marshall, P.C., King, J.A., Ferris, C.F. Epilepsia (2004) [Pubmed]
  34. Characterization of the antiabsence effects of SCH 50911, a GABA-B receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate, and pentylenetetrazole models. Hosford, D.A., Wang, Y., Liu, C.C., Snead, O.C. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
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