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Chemical Compound Review

Anilofos     N-(4-chlorophenyl)-2- dimethoxyphosphinothi...

Synonyms: Anilophos, Arozin, aniloguard, Rico, HOE 574, ...
 
 
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Disease relevance of Arozin

 

High impact information on Arozin

  • No significant alteration in anilofos-mediated production of lipid peroxidation was observed in erythrocyte and brain of isoproturon-pretreated rats, but it was significantly increased in liver [3].
  • GST activity was increased in liver of rats given isoproturon alone (fourfold) or in combination with anilofos (2.8-fold) [3].
  • Anilofos did not affect GSH and GST [3].
  • Activities of total ATPase, Mg2+-ATPase and Na+-K+-ATPase were not affected in rats given either anilofos alone or herbicides in sequence [3].
  • Psticides; fenitrothion and anilofos (aniloguard) were testd as molluscicides against Lymnaea natalensis and Biomplhalaria alexandrina [4].
 

Chemical compound and disease context of Arozin

  • Overall findings of the study indicate that isoproturon pretreatment does not alter the toxicity of anilofos, the GSH-GST metabolic pathway may not have a significant implication in the detoxification of anilofos and the production of a reactive oxygen species may be a factor in mediating anilofos toxicity [3].
 

Biological context of Arozin

  • Effects of anilofos on lipid peroxidation--an index of oxidative stress, ATPase activity--an integral part of active transport mechanisms for cations, GSH level and GST activity were evaluated in blood (erythrocyte/plasma), brain and liver of male rats after daily oral exposure to 50, 100 or 200 mg/kg for 28 days [5].
 

Anatomical context of Arozin

  • Results indicate that anilofos may not cause oxidative damage to cell membrane in repeatedly exposed animals and may cause neuronal/cellular dysfunction by affecting ionic transport across cell membrane [5].
 

Associations of Arozin with other chemical compounds

  • Effects of isoproturon pretreatment (675 mg/kg/day for 3 consecutive days) on the toxic actions of anilofos administered orally as a single dose (850 mg/kg) were evaluated by determining some biochemical attributes in blood (erythrocyte/plasma), brain and liver of rats [3].
  • In was found that the exposure of B. alexandrina to LC25 of fungicide (Isoprothiolane), herbicide (Anilofos) and plant extract (Euphorbia lactea) led to highly significantly elevated in the number of abnormal egg masses laid by treated snails in comparison with the control ones [6].
 

Gene context of Arozin

References

 
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