The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Euphorbia


High impact information on Euphorbia

  • A lipase from the latex of Euphorbia characias was purified using a method involving extraction with apolar solvent and adsorption chromatography on silica gel [6].
  • The chemical forms of inorganic carbon, CO2 or HCO3-, incorporated during photosynthesis in photoautotrophic Euphorbia characias cell suspension cultures were determined in experiments using 13CO2 and a mass spectrometry technique [7].
  • In fact, attempts to understand the hot and painful action of the vanillyl group containing compounds capsaicin (from Capsicum sp.) and its ultrapotent analogue resiniferatoxin (RTX, from Euphorbia sp.) led to the cloning of the vanilloid receptor (TRPV1) 7 years ago [8].
  • We have used the expression of hormone and cell cycle-responsive genes as markers to follow this process in leafy spurge (Euphorbia esula) [9].
  • We previously characterized a calcium-dependent peroxidase isolated from the latex of the Mediterranean shrub Euphorbia characias (ELP) [Medda et al. (2003) Biochemistry 42, 8909-8918] [10].

Chemical compound and disease context of Euphorbia


Biological context of Euphorbia


Anatomical context of Euphorbia


Associations of Euphorbia with chemical compounds

  • We propose that Ca(2+) binding to a low affinity site induces a reorientation of the distal histidine changing the almost inactive form of Euphorbia peroxidase to a high activity form [19].
  • The endosperm of Euphorbia lagascae Spreng. seeds contains high levels of the epoxidated fatty acid vernolic acid [12(S),13(R)-epoxy-12-octadecenoic acid] [20].
  • Aerobic and anaerobic glucose metabolism of Phytomonas sp. isolated from Euphorbia characias [21].
  • In addition, four flavonol glycoside gallates ( 5 - 8) from Euphorbia pekinensis containing the galloyl moiety also showed the inhibitory activity at a level comparable to those of 2 - 4 [3].
  • Irritant diterpene ester toxins were isolated from Euphorbia nubica and E. helioscopia, which are contaminants of the green fodder of livestock in Egypt. Fractionations of methanol extracts of aerial parts of both plants were monitored by the irritation unit on the mouse ear [22].

Gene context of Euphorbia


Analytical, diagnostic and therapeutic context of Euphorbia


  1. Activation of the Epstein-Barr virus lytic cycle by the latex of the plant Euphorbia tirucalli. MacNeil, A., Sumba, O.P., Lutzke, M.L., Moormann, A., Rochford, R. Br. J. Cancer (2003) [Pubmed]
  2. Pubescenes, jatrophane diterpenes, from Euphorbia pubescens, with multidrug resistance reversing activity on mouse lymphoma cells. Valente, C., Ferreira, M.J., Abreu, P.M., Gyémánt, N., Ugocsai, K., Hohmann, J., Molnár, J. Planta Med. (2004) [Pubmed]
  3. Inhibition of HIV-1 integrase by galloyl glucoses from Terminalia chebula and flavonol glycoside gallates from Euphorbia pekinensis. Ahn, M.J., Kim, C.Y., Lee, J.S., Kim, T.G., Kim, S.H., Lee, C.K., Lee, B.B., Shin, C.G., Huh, H., Kim, J. Planta Med. (2002) [Pubmed]
  4. Toxicity of Euphorbia milii latex and niclosamide to snails and nontarget aquatic species. Oliveira-Filho, E.C., Paumgartten, F.J. Ecotoxicol. Environ. Saf. (2000) [Pubmed]
  5. Combined effect of the extracts from Croton tiglium, Euphorbia lathyris or Euphorbia tirucalli and n-butyrate on Epstein-Barr virus expression in human lymphoblastoid P3HR-1 and Raji cells. Ito, Y., Kawanishi, M., Harayama, T., Takabayashi, S. Cancer Lett. (1981) [Pubmed]
  6. Lipases of the euphorbiaceae family: purification of a lipase from Euphorbia characias latex and structure-function relationships with the B chain of ricin. Moulin, A., Teissère, M., Bernard, C., Piéroni, G. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  7. Mass spectrometric determination of the inorganic carbon species assimilated by photoautotrophic cells of Euphorbia characias L. Rebeille, F., Gans, P., Chagvardieff, P., Pean, M., Tapie, P., Thibault, P. J. Biol. Chem. (1988) [Pubmed]
  8. Contribution of natural products to the discovery of the transient receptor potential (TRP) channels family and their functions. Calixto, J.B., Kassuya, C.A., André, E., Ferreira, J. Pharmacol. Ther. (2005) [Pubmed]
  9. Molecular analysis of signals controlling dormancy and growth in underground adventitious buds of leafy spurge. Horvath, D.P., Chao, W.S., Anderson, J.V. Plant Physiol. (2002) [Pubmed]
  10. A Ca2+/calmodulin-binding peroxidase from Euphorbia latex: novel aspects of calcium-hydrogen peroxide cross-talk in the regulation of plant defenses. Mura, A., Medda, R., Longu, S., Floris, G., Rinaldi, A.C., Padiglia, A. Biochemistry (2005) [Pubmed]
  11. Isolation and characterization of methyl esters and derivatives from Euphorbia kansui (Euphorbiaceae) and their inhibitory effects on the human SGC-7901 cells. Yu, F.R., Lian, X.Z., Guo, H.Y., McGuire, P.M., Li, R.D., Wang, R., Yu, F.H. Journal of pharmacy & pharmaceutical sciences [electronic resource] : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques. (2005) [Pubmed]
  12. Jatrophane diterpenes from the latex of Euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain. Betancur-Galvis, L., Checa, J., Marco, J.A., Estornell, E. Planta Med. (2003) [Pubmed]
  13. Molluscicide activity of the "avelós" plant (Euphorbia tirucalli, L.) on Biomphalaria glabrata, the mollusc vector of schistosomiasis. Jurberg, P., Cabral Neto, J.B., Schall, V.T. Mem. Inst. Oswaldo Cruz (1985) [Pubmed]
  14. Neutrophil migration and aggregation induced by euphorbin, a lectin from the latex of Euphorbia milii, var. milii. Dias-Baruffi, M., Sakamoto, M., Rossetto, S., Vozári-Hampe, M.M., Roque-Barreira, M.C. Inflamm. Res. (2000) [Pubmed]
  15. Hepatoprotective compounds from Canarium album and Euphorbia nematocypha. Ito, M., Shimura, H., Watanabe, N., Tamai, M., Hanada, K., Takahashi, A., Tanaka, Y., Arai, K., Zhang, P.L., Chang, R. Chem. Pharm. Bull. (1990) [Pubmed]
  16. Activity of macrocyclic jatrophane diterpenes from Euphorbia kansui in a TrkA fibroblast survival assay. Pan, Q., Ip, F.C., Ip, N.Y., Zhu, H.X., Min, Z.D. J. Nat. Prod. (2004) [Pubmed]
  17. Euphorbium: modern research on its active principle, resiniferatoxin, revives an ancient medicine. Appendino, G., Szallasi, A. Life Sci. (1997) [Pubmed]
  18. Immunosuppressive properties of an ethyl acetate fraction from Euphorbia royleana. Bani, S., Kaul, A., Khan, B., Ahmad, S.F., Suri, K.A., Satti, N.K., Amina, M., Qazi, G.N. Journal of ethnopharmacology. (2005) [Pubmed]
  19. Critical role of Ca2+ ions in the reaction mechanism of Euphorbia characias peroxidase. Medda, R., Padiglia, A., Longu, S., Bellelli, A., Arcovito, A., Cavallo, S., Pedersen, J.Z., Floris, G. Biochemistry (2003) [Pubmed]
  20. A germination-specific epoxide hydrolase from Euphorbia lagascae. Edqvist, J., Farbos, I. Planta (2003) [Pubmed]
  21. Aerobic and anaerobic glucose metabolism of Phytomonas sp. isolated from Euphorbia characias. Chaumont, F., Schanck, A.N., Blum, J.J., Opperdoes, F.R. Mol. Biochem. Parasitol. (1994) [Pubmed]
  22. Dietary cancer risk from conditional cancerogens (tumor promoters) in produce of livestock fed on species of spurge (Euphorbiaceae). V. Skin irriitant and tumor-promoting diterpene ester toxins of the tigliane and ingenane type in the herbs Euphorbia nubica and Euphorbia helioscopia contaminating fodder of livestock. Zayed, S.M., Farghaly, M., Soliman, S.M., Gotta, H., Sorg, B., Hecker, E. J. Cancer Res. Clin. Oncol. (2001) [Pubmed]
  23. Purification and properties of two lectins from the latex of the euphorbiaceous plants Hura crepitans L. (sand-box tree) and Euphorbia characias L. (Mediterranean spurge). Barbieri, L., Falasca, A., Franceschi, C., Licastro, F., Rossi, C.A., Stirpe, F. Biochem. J. (1983) [Pubmed]
  24. Cloning and characterization of cold-regulated glycine-rich RNA-binding protein genes from leafy spurge (Euphorbia esula L.) and comparison to heterologous genomic clones. Horvath, D.P., Olson, P.A. Plant Mol. Biol. (1998) [Pubmed]
  25. Lathyranoic acid A: first secolathyrane diterpenoid in nature from Euphorbia lathyris. Liao, S.G., Zhan, Z.J., Yang, S.P., Yue, J.M. Org. Lett. (2005) [Pubmed]
  26. New macrocyclic lathyrane diterpenes, from Euphorbia lagascae, as inhibitors of multidrug resistance of tumour cells. Duarte, N., Gyémánt, N., Abreu, P.M., Molnár, J., Ferreira, M.J. Planta Med. (2006) [Pubmed]
  27. Preliminary biological assay on cerebroside mixture from Euphorbia nicaeensis All. Isolation and structure determination of five glucocerebrosides. Cateni, F., Zilic, J., Falsone, G., Hollan, F., Frausin, F., Scarcia, V. Farmaco (2003) [Pubmed]
  28. Purification and partial characterization of a mitogenic lectin from the latex of Euphorbia marginata. Stirpe, F., Licastro, F., Morini, M.C., Parente, A., Savino, G., Abbondanza, A., Bolognesi, A., Falasca, A.I., Rossi, C.A. Biochim. Biophys. Acta (1993) [Pubmed]
  29. Antinociceptive activity of Euphorbia heterophylla roots. Vamsidhar, I., Mohammed, A.H., Nataraj, B., Madhusudana Rao, C., Ramesh, M. Fitoterapia (2000) [Pubmed]
WikiGenes - Universities