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Chemical Compound Review

CHEMBL72086     4-amino-1-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: SureCN41572, AG-E-56791, CHEBI:20607, M4254_SIGMA, HMDB00982, ...
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Disease relevance of AIDS189244


High impact information on AIDS189244


Biological context of AIDS189244

  • The marked binding of antibodies specific for 5-methylcytidine to the short arm of chromosome 15 distinguishes this chromosome from the other human acrocentrics [7].
  • Our results suggest that although extensively altered tRNA is a poorer substrate than control tRNA in both extent and rate of aminoacylation, 5-methylcytidine in mammalian tRNA is not involved in the recognition of the tRNA by the synthetase as measured by aminoacylation activity [9].

Anatomical context of AIDS189244

  • In a human lymphoblastoid cell line (Z83) in which rDNA genes on chromosome 22 are amplified but transcribed at a low level, immunocytological studies with antibodies to 5 methylcytidine provided evidence for hypermethylation of the rDNA [10].
  • The study aimed to evaluate the status of global DNA methylation in several types of thyroid tumors using a monoclonal antibody specific for 5-methylcytidine (5-mc) and to define the diagnosis potential of this marker [11].
  • The modified base 5-methylcytidine has been found in the DNA of a number of different eukaryotic cells where it occurs principally in the dinucleotide sequence -CmpG- which is present as a palindrome in double-strand nucleic acid molecules [12].

Associations of AIDS189244 with other chemical compounds


Gene context of AIDS189244

  • Isolation of nucleolar methylase producing only 5-methylcytidine in ribosomal RNA [14].
  • 1. The specificity of a monoclonal IgG1 raised against a 5-methylcytidine-keyhole limpet hemocyanin conjugate was investigated by inhibition experiments with soluble competing antigens [15].
  • One would like to understand the mechanisms by which 5-methylcytidine residues are capable of interfering with regulatory functions in the late E2A promoter of Ad2 [3].

Analytical, diagnostic and therapeutic context of AIDS189244


  1. Effect of 5-methylcytidine on virus production in avian sarcoma virus-infected chicken embryo cells. Guntaka, R.V., Katz, R.A., Weiner, A.J., Widman, M.M. J. Virol. (1979) [Pubmed]
  2. The structure of the RNA m5C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain. Hallberg, B.M., Ericsson, U.B., Johnson, K.A., Andersen, N.M., Douthwaite, S., Nordlund, P., Beuscher, A.E., Erlandsen, H. J. Mol. Biol. (2006) [Pubmed]
  3. Specific factors binding to the late E2A promoter region of adenovirus type 2 DNA: no apparent effects of 5'-CCGG-3' methylation. Hoeveler, A., Doerfler, W. DNA (1987) [Pubmed]
  4. Functionally important regions of the factor IX gene have a low rate of polymorphism and a high rate of mutation in the dinucleotide CpG. Koeberl, D.D., Bottema, C.D., Buerstedde, J.M., Sommer, S.S. Am. J. Hum. Genet. (1989) [Pubmed]
  5. Amplified ribosomal RNA genes in a rat hepatoma cell line are enriched in 5-methylcytosine. Tantravahi, U., Guntaka, R.V., Erlanger, B.F., Miller, O.J. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  6. 5-methylcytosine in the DNA of the polytene chromosomes of the diptera Sciara coprophila, Drosophila melanogaster and D. persimilis. Eastman, E.M., Goodman, R.M., Erlanger, B.F., Miller, O.J. Chromosoma (1980) [Pubmed]
  7. Preferential derivation of abnormal human G-group-like chromosomes from chromosome 15. Schreck, R.R., Breg, W.R., Erlanger, B.F., Miller, O.J. Hum. Genet. (1977) [Pubmed]
  8. DNA hypomethylation and imbalanced expression of DNA methyltransferases (DNMT1, 3A, and 3B) in human uterine leiomyoma. Li, S., Chiang, T.C., Richard-Davis, G., Barrett, J.C., Mclachlan, J.A. Gynecol. Oncol. (2003) [Pubmed]
  9. Aminoacylation of undermethylated mammalian transfer RNA. Harris, J.S., Randerath, K. Biochim. Biophys. Acta (1978) [Pubmed]
  10. Methylation of the 5' flanking sequences of the ribosomal DNA in human cell lines and in a human-hamster hybrid cell line. Dante, R., Percy, M.E., Baldini, A., Markovic, V.D., Miller, D.A., Rocchi, M., Niveleau, A., Miller, O.J. J. Cell. Biochem. (1992) [Pubmed]
  11. Global DNA methylation evaluation: potential complementary marker in differential diagnosis of thyroid neoplasia. Galusca, B., Dumollard, J.M., Lassandre, S., Niveleau, A., Prades, J.M., Estour, B., Peoc'h, M. Virchows Arch. (2005) [Pubmed]
  12. A possible model for the methylation of deoxycytidine in DNA. Hawtrey, A.O., Ariatti, M. Med. Hypotheses (1984) [Pubmed]
  13. Time-resolved fluoroimmunoassay of 5-methyl-2'-deoxycytidine employing europium-labeled antigen as tracer. Rasi, S., Suvanto, E., Vilpo, L.M., Vilpo, J.A. J. Immunol. Methods (1989) [Pubmed]
  14. Isolation of nucleolar methylase producing only 5-methylcytidine in ribosomal RNA. Obara, M., Higashi, K., Kuchino, Y. Biochem. Biophys. Res. Commun. (1982) [Pubmed]
  15. Molecular geometry of antigen binding by a monoclonal antibody against 5-methylcytidine. Podestà, A., Castiglione, M.R., Avanzi, S., Montagnoli, G. Int. J. Biochem. (1993) [Pubmed]
  16. The accessibility of 5-methylcytosine to specific antibodies in double-stranded DNA of Xanthomonas phage XP12. Adouard, V., Dante, R., Niveleau, A., Delain, E., Revet, B., Ehrlich, M. Eur. J. Biochem. (1985) [Pubmed]
  17. 5-Azacytidine inhibits the induction of transient TK-deficient cells by 5-bromodeoxyuridine. A novel hypothesis for the facilitation of hypermethylation by 5-bromodeoxyuridine. Call, K.M., Thilly, W.G. Mutat. Res. (1991) [Pubmed]
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